A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer DOI Open Access

Jiayan Yang,

Ting Wang, Pengchao Wang

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Herein, two deep red phosphorescent responsive emissive cyclometalated iridium (III) complexes with CAIX inhibition moiety was designed and synthesized; they can penetrate into living cells quickly mainly located in the lysosome. They showed a strong binding affinity towards vitro effectively reduced cellular expression of CAIX. Moreover, tethered CAIX‐inhibition benzene sulfonamide decrease inherent cytotoxicity Ir(III) complex normal improve killing selectivity cancer dark; Ir3 Ir4 exhibit approximately five to eight times higher than that cisplatin; satisfied photodynamic therapy effect under irradiation 425 nm, ultimately resulting apoptosis cell, which is accompanied weakening extracellular acidification, increased expression, significant loss mitochondrial membrane potential, elevated level reactive oxygen. our work may demonstrate combination metal photosensitizer provide promising strategy for constructing novel theranostic platform.

Language: Английский

Two-Dimensional Fluorescence and Chemiluminescence Orthogonal Probe for Discriminating and Quantifying Similar Proteins DOI Creative Commons
Juan Li,

Xiuyan Zhao,

Yutao Zhang

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We report an innovative two-dimensional orthogonal strategy which is sequentially triggered with hydrolysis-initiated fluorescence and photocycloaddition-induced chemiluminescence, enabling identification quantitation of human serum albumin bovine albumin.

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI Open Access

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post‐PDT, and limited photodynamic efficiency. Herein, we report photo‐triggered porphyrin polyelectrolyte nanoassembling (photo‐triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal‐ligand coordination. The polyelectrolyte‐based PPN exhibits good biocompatibility, bestows unique “confining isolated” inner microenvironment fully overcoming π–π stacking porphyrins with significant efficiency (123‐fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed‐form, could use light as specific trigger modulate closed‐ open‐form, manipulate 1 O 2 generation three stages: pre‐PDT (quenching generation), during (activating post‐PDT (silencing generation). This de novo strategy first time realized remotely manipulating boosting PDT, well resolving critical general challenges side effects from phototoxicity.

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Citations

0
Theoretically obtained insight into the origin of singlet oxygen chemiluminescence probe, SOCL DOI

Yujie Guo,

Yan Leng, Chungang Min

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140414 - 140414

Published: Oct. 1, 2024

Language: Английский

Citations

0
A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer DOI Open Access

Jiayan Yang,

Ting Wang, Pengchao Wang

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Herein, two deep red phosphorescent responsive emissive cyclometalated iridium (III) complexes with CAIX inhibition moiety was designed and synthesized; they can penetrate into living cells quickly mainly located in the lysosome. They showed a strong binding affinity towards vitro effectively reduced cellular expression of CAIX. Moreover, tethered CAIX‐inhibition benzene sulfonamide decrease inherent cytotoxicity Ir(III) complex normal improve killing selectivity cancer dark; Ir3 Ir4 exhibit approximately five to eight times higher than that cisplatin; satisfied photodynamic therapy effect under irradiation 425 nm, ultimately resulting apoptosis cell, which is accompanied weakening extracellular acidification, increased expression, significant loss mitochondrial membrane potential, elevated level reactive oxygen. our work may demonstrate combination metal photosensitizer provide promising strategy for constructing novel theranostic platform.

Language: Английский

Citations

0