
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 4, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 4, 2024
Language: Английский
RSC Advances, Journal Year: 2025, Volume and Issue: 15(8), P. 6191 - 6207
Published: Jan. 1, 2025
Hydrazone-based compounds distinguished by their azomethine –NHNCH group and respective coinage metal complexes have emerged as leading candidates in the search for effective anticancer antibiotic agents.
Language: Английский
Citations
2Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.
Language: Английский
Citations
1Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: June 1, 2025
Monodisperse oligomers, positioned as intermediates between polymers and small molecules, retain certain reactivities of molecules while simultaneously displaying the initial aggregation characteristics polymers. This distinctive structure bestows on them with significant potential for a wide range applications. In this study, series carbolong osmium oligomers (Os1-Os4) corresponding polymer were evaluated photocatalysts. It was discovered that their molar absorption coefficients reactive oxygen species generation rose π-conjugation length, peaking at polymerization degree 4. Moreover, Os4 facilitates photocatalytic oxidation nicotinamide adenine dinucleotide (NADH) to its oxided form, NAD+. vitro experiments demonstrated had strongest phototoxicity index in cells hypoxic conditions, highlighting efficacy tumor. Metabolomic analyses indicated exerted photocytotoxicity by disrupting purine metabolism. These insights will guide future design π-conjugated metal advancing
Language: Английский
Citations
0Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive
Language: Английский
Citations
1Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 4, 2024
Language: Английский
Citations
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