Novel Cu-II Complexes of 2-Hydroxy 4-Methoxy Benzylidene 2-Hydroxy Benzhydrazide: Synthesis, Spectral Characterization, Thermal, Antimicrobial, Antioxidant and Catalytic activity Study DOI Creative Commons
Sangeeta Korane, Babasaheb D. Bhosale, Amol Maruti Jadhav

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract The novel hydrazone ligand 2-hydroxy 4-methoxy benzylidene benzhydrazide [HL] was prepared by condensing and benzaldehyde in methanol solvent. Cu-II complexes [Cu(HL)(NO3)].1/3H2O (1a), [{Cu (HL)}2 (μ-SO4)].12/3H2O(2a), [Cu(HL)(H2O) Cl](3a) were synthesized refluxing salts CuNO3.3H2O CuSO4.5H2O CuCl2.2H2O with solution of characterized spectral techniques (FT-IR,1H-NMR,13C–NMR,UV-Visible, PXRD study).The are further thermo gravimetric(TG)analysis, molar conductivity, elemental analysis magnetic susceptibility measurement study. FT-IR spectra provides valuable information about different coordination sites. UV-Visible spectroscopy reflect LMCT bands from 242718- 261780 cm-1 and d-d the range 143884-156250 cm-1 addition to n-π*and π -π*transition all complexes. Square planar square pyramidal geometry proposed for as illustrated magnetic, electronic spectroscopic data. X-ray powder diffraction reveals crystalline nature experimental results TGA good agreement data A comparison physicochemical very useful creating correct assignments understanding structure complex. act tribasic tridentate chelating through phenolate oxygen, azomethine nitrogen oxygen enolate donar functionality copper-II ion. antibacterial potential complex catalysts evaluated against human pathogenic bacteria such as Bacillus subtilties, Bacillus cereus, Escherichia coli, Pseudomonas velgaris,and Staphylococcus aureus etc. Also, Cu (II) demonstrate significant antioxidant activity. catalytic performance alcohol oxidation using hydrogen peroxide a green oxidant is also investigated.

Language: Английский

Hydrazones, hydrazones-based coinage metal complexes, and their biological applications DOI Creative Commons
Dessie Ashagrie Tafere, Mamo Gebrezgiabher,

Fikre Elemo

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(8), P. 6191 - 6207

Published: Jan. 1, 2025

Hydrazone-based compounds distinguished by their azomethine –NHNCH group and respective coinage metal complexes have emerged as leading candidates in the search for effective anticancer antibiotic agents.

Language: Английский

Citations

2
The Regulation of Trace Metal Elements in Cancer Ferroptosis DOI Creative Commons

Xiaoyan Wang,

Yuanyuan Xue, Lei Chang

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

Citations

1
Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy DOI
Shiyan Chen, Guotao Yuan, Liu Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Monodisperse oligomers, positioned as intermediates between polymers and small molecules, retain certain reactivities of molecules while simultaneously displaying the initial aggregation characteristics polymers. This distinctive structure bestows on them with significant potential for a wide range applications. In this study, series carbolong osmium oligomers (Os1-Os4) corresponding polymer were evaluated photocatalysts. It was discovered that their molar absorption coefficients reactive oxygen species generation rose π-conjugation length, peaking at polymerization degree 4. Moreover, Os4 facilitates photocatalytic oxidation nicotinamide adenine dinucleotide (NADH) to its oxided form, NAD+. vitro experiments demonstrated had strongest phototoxicity index in cells hypoxic conditions, highlighting efficacy tumor. Metabolomic analyses indicated exerted photocytotoxicity by disrupting purine metabolism. These insights will guide future design π-conjugated metal advancing

Language: Английский

Citations

0
Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies DOI Creative Commons
Bishnu Das

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive

Language: Английский

Citations

1
Novel Cu-II Complexes of 2-Hydroxy 4-Methoxy Benzylidene 2-Hydroxy Benzhydrazide: Synthesis, Spectral Characterization, Thermal, Antimicrobial, Antioxidant and Catalytic activity Study DOI Creative Commons
Sangeeta Korane, Babasaheb D. Bhosale, Amol Maruti Jadhav

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract The novel hydrazone ligand 2-hydroxy 4-methoxy benzylidene benzhydrazide [HL] was prepared by condensing and benzaldehyde in methanol solvent. Cu-II complexes [Cu(HL)(NO3)].1/3H2O (1a), [{Cu (HL)}2 (μ-SO4)].12/3H2O(2a), [Cu(HL)(H2O) Cl](3a) were synthesized refluxing salts CuNO3.3H2O CuSO4.5H2O CuCl2.2H2O with solution of characterized spectral techniques (FT-IR,1H-NMR,13C–NMR,UV-Visible, PXRD study).The are further thermo gravimetric(TG)analysis, molar conductivity, elemental analysis magnetic susceptibility measurement study. FT-IR spectra provides valuable information about different coordination sites. UV-Visible spectroscopy reflect LMCT bands from 242718- 261780 cm-1 and d-d the range 143884-156250 cm-1 addition to n-π*and π -π*transition all complexes. Square planar square pyramidal geometry proposed for as illustrated magnetic, electronic spectroscopic data. X-ray powder diffraction reveals crystalline nature experimental results TGA good agreement data A comparison physicochemical very useful creating correct assignments understanding structure complex. act tribasic tridentate chelating through phenolate oxygen, azomethine nitrogen oxygen enolate donar functionality copper-II ion. antibacterial potential complex catalysts evaluated against human pathogenic bacteria such as Bacillus subtilties, Bacillus cereus, Escherichia coli, Pseudomonas velgaris,and Staphylococcus aureus etc. Also, Cu (II) demonstrate significant antioxidant activity. catalytic performance alcohol oxidation using hydrogen peroxide a green oxidant is also investigated.

Language: Английский

Citations

0