One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 408 - 418

Published: Dec. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Language: Английский

Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy DOI Creative Commons
Subhrakant Jena,

Pranay Mohanty,

L. K. Dash

et al.

ChemPhotoChem, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Phototherapy, encompassing photodynamic therapy (PDT) and photothermal (PTT), presents a promising cancer treatment strategy with high spatial specificity minimal invasiveness. Optimizing these techniques hinges on the design of high‐performance photosensitizers (PSs) agents (PTAs). Single‐atom chalcogen substitution, at both endocyclic exocyclic positions in conventional organic chromophores, has proven to be novel for enhancing their photophysical photochemical properties. Ideal PSs/PTAs exhibit biocompatibility, visible‐to‐near‐infrared (vis–NIR) absorption, efficient triplet state harvesting, feasible heat energy transfer efficiency. Moreover, chalcogen‐based show promise synergistic multimodal therapies, integrating imaging treatment. This review comprehensively examines recent advancements (within last five years) utilizing substitution robust PDT/PTT. It provides holistic perspective spectroscopic characterization computational analyses, singlet‐oxygen/triplet quantum yields, generation efficiency, vitro/in vivo biological evaluations chalcogen‐substituted PSs/PTAs. is anticipated that this will stimulate further research endeavors area.

Language: Английский

Citations

0
Nanozymes in cancer immunotherapy: metabolic disruption and therapeutic synergy DOI Creative Commons
X Xu, Yaowen Zhang,

Chijun Meng

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9111 - 9143

Published: Jan. 1, 2024

The unique roles of nanozymes in enhancing immunotherapy through disrupting tumor metabolism and mediating combination therapies.

Language: Английский

Citations

2
Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies DOI Creative Commons
Bishnu Das

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive

Language: Английский

Citations

1
Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors DOI
Liang Chen,

Jierou Huang,

Ming Tong

et al.

Luminescence, Journal Year: 2024, Volume and Issue: 39(10)

Published: Oct. 1, 2024

ABSTRACT Phototheranostics with near‐infrared fluorescence and reactive oxygen species generation ability high photothermal conversion efficiency (PCE) plays a significant role in imaging‐guided synergetic photodynamic therapy of tumors. Here, star molecule organic photovoltaic materials, NCBDT‐4C an A‐D‐A conjugated structure, was assembled DSPE‐PEG‐NH 2 to prepare water dispersive nanoparticles (NPs). The prepared NCBDT‐4Cl NPs exhibited maximum NIR absorption peak at 764 nm 798 nm. These could generate superoxide anion, singlet ( 1 O ), heat under 808 laser irradiation. quantum yield PCE the were 37.5% 53.6%, respectively. combination cancer demonstrated vitro vivo. This work presents advanced application materials phototherapy.

Language: Английский

Citations

0
One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 408 - 418

Published: Dec. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Language: Английский

Citations

0