Bone,
Journal Year:
2019,
Volume and Issue:
131, P. 115160 - 115160
Published: Nov. 20, 2019
Studies
have
shown
that
osteoporosis
and
atherosclerosis
are
comorbid
conditions
sharing
common
risk
factors
pathophysiological
mechanisms.
Understanding
these
is
crucial
in
order
to
develop
shared
methods
for
stratification,
prevention,
diagnosis
treatment.
The
aim
of
this
study
was
apply
a
system-level
bioinformatics
approach
lipidome-wide
data
pinpoint
the
lipidomic
architecture
jointly
associated
with
surrogate
markers
complex
diseases.
based
on
Cardiovascular
Risk
Young
Finns
Study
cohort
from
2007
follow-up
(n
=
1494,
aged
30–45
years,
women:
57%).
Liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
used
analyse
serum
lipidome,
involving
437
molecular
lipid
species.
subclinical
osteoporotic
included
indices
bone
mineral
density
content,
measured
using
peripheral
quantitative
computer
tomography
distal
shaft
sites
both
tibia
radius.
atherosclerotic
carotid
bulbus
intima
media
thickness
high-resolution
ultrasound.
Weighted
co-expression
network
analysis
performed
identify
networks
densely
interconnected
species
(i.e.
modules)
atherosclerosis.
levels
(lipid
profiles)
each
modules
were
summarized
by
first
principal
component
termed
as
module
eigenlipid.
Then,
Pearson's
correlation
(r)
calculated
between
eigenlipids
markers.
Lipid
significantly
correlated
considered
be
related
comorbidities.
hypothesis
profiles
constituent
joint
effects
tested
multivariate
variance
(MANOVA).
Among
twelve
studied
modules,
we
identified
one
105
(r
0.24,
p-value
2
×
10−20)
0.16,
10−10).
majority
belonged
glycerolipid
60),
glycerophospholipid
13)
sphingolipid
29)
classes.
also
enriched
ceramides
20),
confirming
their
significance
cardiovascular
outcomes
suggesting
role
top
three
37
statistically
significant
(adjusted
<
0.05)
within
all
triacylglycerols
(TAGs)
–
TAG(18:0/18:0/18:1)
an
adjusted
8.6
10−8,
TAG(18:0/18:1/18:1)
3.7
10−6,
TAG(16:0/18:0/18:1)
8.5
10−6.
This
novel
Alterations
metabolism
and,
more
specifically,
TAG
lipids
may
provide
potential
new
biomarkers
testing
comorbidities,
opening
avenues
emergence
dual-purpose
prevention
measures.
Frontiers in Molecular Biosciences,
Journal Year:
2022,
Volume and Issue:
9
Published: May 25, 2022
Cardiovascular
disease
(CVD)
is
still
the
leading
cause
of
death
globally,
and
atherosclerosis
main
pathological
basis
CVDs.
Low-density
lipoprotein
cholesterol
(LDL-C)
a
strong
causal
factor
atherosclerosis.
However,
first-line
lipid-lowering
drugs,
statins,
only
reduce
approximately
30%
CVD
risk.
Of
note,
atherosclerotic
(ASCVD)
cannot
be
eliminated
in
great
number
patients
even
their
LDL-C
levels
meet
recommended
clinical
goals.
Previously,
whether
elevated
plasma
level
triglyceride
causally
associated
with
ASCVD
has
been
controversial.
Recent
genetic
epidemiological
studies
have
demonstrated
that
triglyceride-rich
(TGRL)
are
risk
factors
residual
ASCVD.
TGRLs
metabolites
can
promote
via
modulating
inflammation,
oxidative
stress,
formation
foam
cells.
In
this
article,
we
will
make
short
review
TG
TGRL
metabolism,
display
evidence
association
between
ASCVD,
summarize
atherogenic
metabolites,
discuss
current
findings
advances
TG-lowering
therapies.
This
provides
information
useful
for
researchers
field
as
well
pharmacologists
clinicians.
Current Cardiology Reviews,
Journal Year:
2018,
Volume and Issue:
14(1), P. 67 - 76
Published: March 2, 2018
Background:
Prevention
and
treatment
of
dyslipidemias
represent
the
key
issues
Cardiovascular
Disease
(CVD)
prophylaxis.
Consequently,
effective
management
different
types
lipid
disorders,
including
hypertriglyceridemia,
should
be
a
priority
for
healthcare
practitioners
(e.g.:
cardiology
endocrinology
specialists,
primary
care
physicians,
dietitians,
pharmacists),
who
provide
medical
care,
as
well
patients,
receive
this
need
to
directly
engaged
in
it,
order
improve
their
outcomes.
The
aim
review
is
facilitate
translation
current
trends
hypertriglyceridemia
into
daily
practice.
article
focuses
on
common
causes
consequences
discusses
diagnostic
evaluation
therapeutic
options
patients
with
high
Triglyceride
(TG)
levels
CVD
risk.
Conclusion:
This
presents
main
practice-related
strategies,
based
guidelines
risk,
according
European
Society
Cardiology
(ESC),
Atherosclerosis
(EAS),
American
College
(ACC)/American
Heart
Association
(AHA),
both
non-pharmacological,
pharmacological
approaches.
It
also
addresses
beneficial
impact
pharmaceutical
Care
(PC)
interventions
clinical
outcomes
disorders
risk
(in
light
Randomized
Controlled
Trials
(RCT)
data),
underlines
importance
close
cooperation
between
physicians
pharmacists,
manage
such
patients.
Keywords:
Diseases
(CVD),
dyslipidemia,
patient
management,
Pharmaceutical
(PC),
levels.
International Heart Journal,
Journal Year:
2025,
Volume and Issue:
66(1), P. 144 - 156
Published: Jan. 30, 2025
Maternal
overnutrition
correlates
with
detrimental
outcomes
in
offspring.
However,
the
specific
effects
of
gestational
exposure
to
a
high-fat
diet
(HFD)
on
fetal
development
remain
unclear.
This
study
aimed
elucidate
developmental
phenotypes
neonatal
organs
and
cardiomyocytes
mice
exposed
HFD,
revealing
growth
retardation
notable
reduction
cardiomyocyte
cell
cycle
activity.
In
this
study,
an
HFD
model
was
used
investigate
maternal
offspring
development.
Defective
observed
offspring,
severe
restriction
proliferation
noted
as
result
HFD.
Based
evidence,
we
detected
Moreover,
RNA
sequencing
analysis
revealed
that
diminished
fatty
acid
metabolism,
enhanced
inflammatory
response,
upregulated
transcription
genes
involved
Tp53-regulated
arrest
postnatal
day
0
(P0)
cardiomyocytes.
Furthermore,
our
results
showed
during
gestation
are
profound
normal
lactation
feeding
after
delivery
cannot
help
adult
recover
from
defective
heart
These
findings
highlight
diverse
pathways
affected
by
particularly
implicating
potential
TP53-dependent
mechanism
contributing
cardiac
defects
Journal of Lipid Research,
Journal Year:
2008,
Volume and Issue:
50(5), P. 870 - 879
Published: Dec. 17, 2008
This
study
questioned
the
role
of
paraoxonase
2
(PON2)
in
attenuation
macrophage
lipids
accumulation.
Mouse
peritoneal
macrophages
(MPMs)
harvested
from
PON2-deficient
mice
versus
control
C57BL/6
mice,
look
like
foam
cells
and
were
larger
size
filled
with
lipid
droplets.
Macrophage
triglyceride
(but
not
cholesterol)
content,
biosynthesis
rate,
microsomal
acyl-CoA:diacylglycerol
acyltransferase
1
(DGAT1)
activity
(not
mRNA
protein)
MPM
all
significantly
increased
by
4.6-,
3.6-,
4.4-fold,
respectively.
Similarly,
DGAT1
cellular
content
decreased
human
PON2-transfected
as
well
upon
incubation
recombinant
PON2.
In
above
experimental
systems,
PON2
also
oxidative
state.
Incubation
free
radicals
generator
2,2'-amidinopropane
hydrochloride
stress
2.2-
3.4-fold,
respectively,
whereas
microsomes
superoxide
dismutase
40%.
We
thus
conclude
that
attenuates
accumulation
cell
formation
via
inhibition
activity,
which
appears
to
be
sensitive
Bone,
Journal Year:
2019,
Volume and Issue:
131, P. 115160 - 115160
Published: Nov. 20, 2019
Studies
have
shown
that
osteoporosis
and
atherosclerosis
are
comorbid
conditions
sharing
common
risk
factors
pathophysiological
mechanisms.
Understanding
these
is
crucial
in
order
to
develop
shared
methods
for
stratification,
prevention,
diagnosis
treatment.
The
aim
of
this
study
was
apply
a
system-level
bioinformatics
approach
lipidome-wide
data
pinpoint
the
lipidomic
architecture
jointly
associated
with
surrogate
markers
complex
diseases.
based
on
Cardiovascular
Risk
Young
Finns
Study
cohort
from
2007
follow-up
(n
=
1494,
aged
30–45
years,
women:
57%).
Liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
used
analyse
serum
lipidome,
involving
437
molecular
lipid
species.
subclinical
osteoporotic
included
indices
bone
mineral
density
content,
measured
using
peripheral
quantitative
computer
tomography
distal
shaft
sites
both
tibia
radius.
atherosclerotic
carotid
bulbus
intima
media
thickness
high-resolution
ultrasound.
Weighted
co-expression
network
analysis
performed
identify
networks
densely
interconnected
species
(i.e.
modules)
atherosclerosis.
levels
(lipid
profiles)
each
modules
were
summarized
by
first
principal
component
termed
as
module
eigenlipid.
Then,
Pearson's
correlation
(r)
calculated
between
eigenlipids
markers.
Lipid
significantly
correlated
considered
be
related
comorbidities.
hypothesis
profiles
constituent
joint
effects
tested
multivariate
variance
(MANOVA).
Among
twelve
studied
modules,
we
identified
one
105
(r
0.24,
p-value
2
×
10−20)
0.16,
10−10).
majority
belonged
glycerolipid
60),
glycerophospholipid
13)
sphingolipid
29)
classes.
also
enriched
ceramides
20),
confirming
their
significance
cardiovascular
outcomes
suggesting
role
top
three
37
statistically
significant
(adjusted
<
0.05)
within
all
triacylglycerols
(TAGs)
–
TAG(18:0/18:0/18:1)
an
adjusted
8.6
10−8,
TAG(18:0/18:1/18:1)
3.7
10−6,
TAG(16:0/18:0/18:1)
8.5
10−6.
This
novel
Alterations
metabolism
and,
more
specifically,
TAG
lipids
may
provide
potential
new
biomarkers
testing
comorbidities,
opening
avenues
emergence
dual-purpose
prevention
measures.
