The role of lncRNA H19/Hmox1 axis regulating ferroptosis in anthracycline-induced cardiotoxicity DOI

Bayan Kadeerbieke,

Li Wu, Yuanming Zhang

et al.

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 28, 2025

This study investigates the molecular mechanisms underlying anthracyclines (ANT)-induced cardiotoxicity, with a specific focus on ferroptosis regulated by long non-coding RNA (lncRNA) H19/heme oxygenase-1 (Hmox1) signaling axis. A retrospective analysis was performed 50 breast cancer patients who developed ANT-associated cardiac dysfunction. Clinical assessments included measurements of left ventricular ejection fraction (LVEF) and serum markers, such as troponin I (cTnI), creatine kinase-MB (CK-MB), N-terminal pro-B-type natriuretic peptide (NT-proBNP), iron levels. Serum revealed marked downregulation lncRNA H19 upregulation Hmox1, both significantly correlated impaired function disrupted homeostasis. To further elucidate mechanism, an Epirubicin (EPI)-induced injury model in HL-1 cardiomyocytes established. EPI exposure led to suppression H19, induction apoptosis ferroptotic cell death. RNA-seq identified potential downstream targets linking metabolism via Hmox1 modulation. Functional assays demonstrated that overexpression mitigated EPI-induced ferroptosis, while enforced expression reversed these protective effects. Collectively, findings identify H19/Hmox1 axis critical regulator ANT-induced cardiotoxicity suggest it therapeutic target for mitigating undergoing anthracycline chemotherapy.

Language: Английский

Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease DOI
Andrea Caporali, Maryam Anwar, Yvan Devaux

et al.

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 573

Published: March 18, 2024

Language: Английский

Citations

26
Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology DOI
Tommaso Angelone, Carmine Rocca, Vincenzo Lionetti

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 369 - 432

Published: Feb. 1, 2024

Physiological levels of reactive oxygen and nitrogen species (ROS/RNS) function as fundamental messengers for many cellular developmental processes in the cardiovascular system. ROS/RNS involved cardiac redox-signaling originate from diverse sources, their are tightly controlled by key endogenous antioxidant systems that counteract accumulation. However, dysregulated redox-stress resulting inefficient removal leads to inflammation, mitochondrial dysfunction, cell death, contributing development progression disease (CVD).

Language: Английский

Citations

19
Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies DOI Creative Commons
Joseph Adu‐Amankwaah,

Qiang You,

Xinying Liu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.

Language: Английский

Citations

2
Long Non-Coding RNAs: Crucial Regulators in Alzheimer’s Disease Pathogenesis and Prospects for Precision Medicine DOI

Chenbo Yang,

Yiwei Li, Chao Chen

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

1
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction DOI Creative Commons

Elisabeth A. Jalink,

Amber W. Schonk, Reinier A. Boon

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 8, 2024

Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, treatment option for HFpEF still limited, indicating our ongoing incomplete understanding on underlying molecular mechanisms. Non-coding RNAs, comprising microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular (circRNAs), are non-protein coding RNA transcripts, which implicated various diseases. However, their role pathogenesis unknown. Here, we discuss miRNAs, lncRNAs circRNAs that involved pathophysiology HFpEF, namely microvascular dysfunction, inflammation, diastolic dysfunction cardiac fibrosis. We interrogated evidence dissected mechanisms ncRNAs by looking at relevant vivo vitro models mimic co-morbidities patients HFpEF. Finally, potential as biomarkers novel therapeutic targets future treatment.

Language: Английский

Citations

9
Identification of novel target genes in exaggerated cardiac remodeling following myocardial infarction in diabetes DOI Creative Commons
Yanru Duan, Shihan Zhang,

Yihua Xia

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Diabetes mellitus is a major risk factor for myocardial infarction (MI), yet its molecular mechanisms exacerbating post-MI cardiac remodeling remain unclear. Type 2 diabetes mouse model was developed through high-sugar and high-fat diet (HFD), followed by MI surgery. Four weeks post-surgery, function evaluated via echocardiography, pathology examined using Masson's trichrome wheat germ agglutinin staining. High-throughput sequencing identified differentially expressed mRNAs long non-coding RNAs (LncRNAs) in diabetic mice with MI. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway analyses, along LncRNA-target-gene analysis, were performed. Validation human samples patients STEMI confirmed the influence HFD on expression specific genes. The results demonstrate that significantly impairs function, exacerbates fibrosis hypertrophy. In addition, our extensive examination has conclusively demonstrated modulates genes (Rapgef5 Ing1) within tissue individuals afflicted STEMI, underscoring intricate interplay between these conditions. we have found Rapgef5 Ing1 are involved diabetes-mediated cardiomyocyte apoptosis proliferation following infarction. aggravates Rapgef5/Ing1-mediated proliferation, findings highlight novel therapeutic targets cardiovascular complications.

Language: Английский

Citations

1
Short-Term and Long-Term Effects of Inhaled Ultrafine Particles on Blood Markers of Cardiovascular Diseases: A Systematic Review and Meta-Analysis DOI Open Access
Joanna Izabela Lachowicz, Paweł Gać

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2846 - 2846

Published: April 21, 2025

Background/Objectives: Air pollution is the highest environmental risk factor of mortality and morbidity worldwide, leading to over 4 million deaths each year. Among different air pollutants, ultrafine particles (UFPs) constitute cardiovascular diseases (CVDs). Epidemiological studies have associated UFPs with short- long-term imbalance numerous blood markers. Our objective was systematically review short-term impact UFP exposure on markers CVDs. Methods: We prepared systematic CVD meta-analyses effects high-sensitivity C-reactive protein (hsCRP) concentration. The eligibility criteria were established use Provider, Enrollment, Chain, Ownership System (PECOS) model, literature search conducted in Web Science, PubMed, Scopus databases from 1 January 2013 9 2025. bias (RoB) according a World Health Organization (WHO) template. Results: results showed an increase hsCRP as result both UFPs. Moreover, IL-6 IL-1β together other inflammatory increased after exposure. In addition, nucleic acids, among which miR-24-3p let-7d-5p, differentially expressed (DE) Chronic could lead persistent Conclusions: findings underline that may development and/or worsening outcomes fragile populations living air-polluted areas.

Language: Английский

Citations

1
LINC01089 in cancer: multifunctional roles and therapeutic implications DOI Creative Commons

Qiang Yi,

Gangfeng Zhu,

Xinting Ouyang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

Citations

6
Implications of LncRNAs and CircRNAs in psoriasis: a review DOI Creative Commons

Rongcan Shi,

Rui Ma, Xingyu Jiang

et al.

RNA Biology, Journal Year: 2023, Volume and Issue: 20(1), P. 334 - 347

Published: June 13, 2023

Psoriasis is a chronic inflammatory skin disease characterized by infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) circular (circRNAs), comprise the majority genome transcripts are important influencers gene transcription post-transcription modulations. Emerging roles in psoriasis were identified recently. This review summarizes existing studies psoriasis-related lncRNAs circRNAs. A considerable proportion studied circRNAs regulate keratinocyte mobility, such as proliferation differentiation. Some tightly related to inflammation reactions. Other reports demonstrated that they also implicated modulating cell differentiation, proliferation, activation. might illuminate future research highlight act therapeutic targets.

Language: Английский

Citations

13
Phloretin alleviates palmitic acid-induced oxidative stress in HUVEC cells by suppressing the expression of LncBAG6-AS DOI
Jie Li, Qing Yang, Hongfei Liu

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(20), P. 9350 - 9363

Published: Jan. 1, 2023

Oxidative stress (OS) is an important trigger of vascular endothelial injury (VEI), which then leads to cardiovascular disease (CVDs). Phloretin was previously investigated alleviate OS in human umbilical vein cells (HUVECs) by activating the AMPK/Nrf2 pathway; however, whether phloretin exerts health benefits targeting non-coding RNAs (ncRNAs) remains unclear. Herein, whole transcriptome sequencing and lncRNA library building were performed on HUVECs, a commonly used cell line for CVDs study, from different groups control (CK), palmitic acid (PA, 100 μM), PA + (50 μM, G50). KEGG analysis demonstrated that DE-lncRNAs regulated pathway related metabolism HUVECs. LncBAG6-AS highly expressed under stimulation, reversed co-treatment. Moreover, MMP, activities SOD, GSH-Px, T-AOC GR significantly ameliorated after interference LncBAG6-AS, consistent with recover group. Furthermore, expression DE-genes reported mRNA sequencing, including MAPK10, PIK3R1, ATP2B4, AKT2, ADCY9, changed interference, indicating may participate process attenuation through regulating gene expression. So, HUVECs knockdown subsequently "NC vs. si-ASO-LncBAG6-AS" enriched GO terms, such as apoptosis, response OS, ferroptosis, others, similar those observed analysis. Overall, this study provides new insights into molecular mechanisms bioactive substances potential targets early prevention treatment VEI.

Language: Английский

Citations

10