Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing DOI Creative Commons
Diewertje I. Bink, Jessica Pauli, Lars Mäegdefessel

et al.

Atherosclerosis, Journal Year: 2023, Volume and Issue: 374, P. 99 - 106

Published: April 5, 2023

Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play important role development of atherosclerosis. Non-coding RNA like microRNAs long non-coding RNAs are known to function implicated disease progression. Here, we summarize several have altered expression with aging discuss their cell senescence. These processes contribute aging-induced atherosclerosis by targeting controlling senescence, can potentially be attenuated.

Language: Английский

Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease DOI
Andrea Caporali, Maryam Anwar, Yvan Devaux

et al.

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 573

Published: March 18, 2024

Language: Английский

Citations

22
Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology DOI
Tommaso Angelone, Carmine Rocca, Vincenzo Lionetti

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 369 - 432

Published: Feb. 1, 2024

Physiological levels of reactive oxygen and nitrogen species (ROS/RNS) function as fundamental messengers for many cellular developmental processes in the cardiovascular system. ROS/RNS involved cardiac redox-signaling originate from diverse sources, their are tightly controlled by key endogenous antioxidant systems that counteract accumulation. However, dysregulated redox-stress resulting inefficient removal leads to inflammation, mitochondrial dysfunction, cell death, contributing development progression disease (CVD).

Language: Английский

Citations

18
Long Non-Coding RNAs: Crucial Regulators in Alzheimer’s Disease Pathogenesis and Prospects for Precision Medicine DOI

Chenbo Yang,

Yiwei Li, Chao Chen

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

1
Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies DOI Creative Commons
Joseph Adu‐Amankwaah,

Qiang You,

Xinying Liu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.

Language: Английский

Citations

1
Identification of novel target genes in exaggerated cardiac remodeling following myocardial infarction in diabetes DOI Creative Commons
Yanru Duan, Shihan Zhang,

Yihua Xia

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Diabetes mellitus is a major risk factor for myocardial infarction (MI), yet its molecular mechanisms exacerbating post-MI cardiac remodeling remain unclear. Type 2 diabetes mouse model was developed through high-sugar and high-fat diet (HFD), followed by MI surgery. Four weeks post-surgery, function evaluated via echocardiography, pathology examined using Masson's trichrome wheat germ agglutinin staining. High-throughput sequencing identified differentially expressed mRNAs long non-coding RNAs (LncRNAs) in diabetic mice with MI. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway analyses, along LncRNA-target-gene analysis, were performed. Validation human samples patients STEMI confirmed the influence HFD on expression specific genes. The results demonstrate that significantly impairs function, exacerbates fibrosis hypertrophy. In addition, our extensive examination has conclusively demonstrated modulates genes (Rapgef5 Ing1) within tissue individuals afflicted STEMI, underscoring intricate interplay between these conditions. we have found Rapgef5 Ing1 are involved diabetes-mediated cardiomyocyte apoptosis proliferation following infarction. aggravates Rapgef5/Ing1-mediated proliferation, findings highlight novel therapeutic targets cardiovascular complications.

Language: Английский

Citations

1
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction DOI Creative Commons

Elisabeth A. Jalink,

Amber W. Schonk, Reinier A. Boon

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 8, 2024

Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, treatment option for HFpEF still limited, indicating our ongoing incomplete understanding on underlying molecular mechanisms. Non-coding RNAs, comprising microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular (circRNAs), are non-protein coding RNA transcripts, which implicated various diseases. However, their role pathogenesis unknown. Here, we discuss miRNAs, lncRNAs circRNAs that involved pathophysiology HFpEF, namely microvascular dysfunction, inflammation, diastolic dysfunction cardiac fibrosis. We interrogated evidence dissected mechanisms ncRNAs by looking at relevant vivo vitro models mimic co-morbidities patients HFpEF. Finally, potential as biomarkers novel therapeutic targets future treatment.

Language: Английский

Citations

8
LINC01089 in cancer: multifunctional roles and therapeutic implications DOI Creative Commons

Qiang Yi,

Gangfeng Zhu,

Xinting Ouyang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

Citations

5
Implications of LncRNAs and CircRNAs in psoriasis: a review DOI Creative Commons

Rongcan Shi,

Rui Ma, Xingyu Jiang

et al.

RNA Biology, Journal Year: 2023, Volume and Issue: 20(1), P. 334 - 347

Published: June 13, 2023

Psoriasis is a chronic inflammatory skin disease characterized by infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) circular (circRNAs), comprise the majority genome transcripts are important influencers gene transcription post-transcription modulations. Emerging roles in psoriasis were identified recently. This review summarizes existing studies psoriasis-related lncRNAs circRNAs. A considerable proportion studied circRNAs regulate keratinocyte mobility, such as proliferation differentiation. Some tightly related to inflammation reactions. Other reports demonstrated that they also implicated modulating cell differentiation, proliferation, activation. might illuminate future research highlight act therapeutic targets.

Language: Английский

Citations

11
Progress on long non-coding RNAs in calcific aortic valve disease DOI Creative Commons
Yan Shen, Jiahui Li, Zehao Zhao

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 17, 2025

Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged significant regulators of gene expression, playing crucial roles occurrence progression various diseases. Research has shown that lncRNAs participate pathological process underlying CAVD regulating osteogenic differentiation inflammatory response interstitial cells. Specifically, lncRNAs, H19, MALAT1, TUG1, are closely associated with CAVD. Some can act miRNA sponges, form complex regulatory networks, modulate expression calcification-related genes. brief, this review discusses mechanisms potential therapeutic targets

Language: Английский

Citations

0
Cell-Free Nucleic Acids for Early Diagnosis of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis DOI Open Access
Xiaodan Zhang, Yuzhou Cai, Brian Sit

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1530 - 1530

Published: Feb. 12, 2025

Rapid identification of acute ischemic stroke (AIS) is challenging in both pre-hospital and hospital settings. We aimed to identify the most promising cell-free nucleic acids (cfNAs) as diagnostic biomarkers for IS within 72 h from symptom onset. searched PubMed, Web Science, EMBASE, Cochrane Library published articles that evaluated blood cfNAs early diagnosis AIS until 10 May 2023. The performances individual were pooled by random-effects meta-analysis based on fold change biomarkers' level between non-AIS patients. Of 2955 records, 66 reporting 143 different met inclusion criteria. median sample size was 110, 21.4% studies performed validation. Among selected high-quality studies, miR-106b-5p, miR-124, miR-155, lncRNA H19, cfDNA showed good performance. Data four involving 355 patients 97 controls meta-analysis, which a significant (pooled ratio 1.48, 95% confidence interval 1.23-1.79, p < 0.001). This review highlights cfDNA, H19 are diagnosis, further research needed verification.

Language: Английский

Citations

0