Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115603 - 115603
Published: Sept. 28, 2023
The
pathophysiology
of
psoriasis
is
a
highly
complicated
one.
Due
to
the
disease's
specificity,
it
not
only
affects
patient's
skin
negatively
but
also
manifests
systemic
pathological
changes.
These
clinical
symptoms
seriously
harm
physical
and
mental
health.
IFN,
common
immunomodulatory
factor,
has
been
increasingly
demonstrated
have
significant
role
in
development
psoriatic
disease.
Psoriasis
connected
with
variety
immunological
responses.
New
targets
for
therapy
autoimmune
diseases
may
emerge
from
further
research
on
mechanics
associated
IFN
upstream
downstream
pathways.
Different
forms
IFNs
do
behave
same
manner
psoriasis,
understanding
how
different
types
are
involved
provide
better
notion
future
research.
This
review
focuses
involvement
three
related
therapeutic
investigations,
briefly
describing
IFNs'
production
signaling,
as
well
dual
effects
skin.
It
intended
that
would
serve
model
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10152 - 10152
Published: Sept. 21, 2024
Many
skin
diseases
begin
with
inflammatory
changes
on
a
molecular
level.
To
develop
more
thorough
understanding
of
pathology
and
to
identify
new
targets
for
therapeutic
advancements,
mechanisms
inflammation
in
the
context
disease
should
be
studied.
Current
research
efforts
better
understand
have
focused
examining
role
processes
at
several
stages
response
such
as
dysregulation
innate
immunity
sensors,
disruption
both
transcriptional
post-transcriptional
regulation,
crosstalk
between
immune
neuronal
(neuro-immune
crosstalk).
This
review
seeks
summarize
recent
developments
our
highlight
opportunities
advancements.
With
focus
publications
within
past
5
years
(2019–2024),
databases
PubMed
EBSCOhost
were
used
search
peer-reviewed
papers
regarding
disease.
Several
themes
interest
determined
through
extensive
included
based
their
relative
representation
current
potential.
psoriasis,
atopic
dermatitis,
hidradenitis
suppurativa,
scleroderma
described
paper
demonstrate
widespread
influence
Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(2), P. 594 - 601
Published: Feb. 1, 2024
Keratinocytes,
the
principal
epidermal
cells,
play
a
vital
role
in
maintaining
structural
integrity
and
functionality
of
skin.
Beyond
their
protective
role,
keratinocytes
are
key
contributors
to
process
wound
healing,
as
they
migrate
injury
sites,
proliferate,
generate
new
layers
epidermis,
facilitating
tissue
repair
remodeling.
Moreover,
actively
participate
skin's
immune
responses,
expressing
pattern
recognition
receptors
(PRRs)
detect
microbial
components
interact
with
cells
influence
adaptive
immunity.
Keratinocytes
express
diverse
repertoire
signaling
pathways,
transcription
factors,
epigenetic
regulators
regulate
growth,
differentiation,
response
environmental
cues.
Among
these
regulatory
elements,
long
non-coding
RNAs
(lncRNAs)
have
emerged
essential
players
keratinocyte
biology.
LncRNAs,
including
MALAT1,
roles
gene
regulation
cellular
processes,
influencing
proliferation,
migration,
stimuli.
Dysregulation
specific
lncRNAs
such
MALAT1
can
disrupt
homeostasis,
leading
impaired
compromised
barrier
integrity,
contributing
pathogenesis
various
skin
disorders.
Understanding
intricate
interplay
between
offers
promising
insights
into
molecular
underpinnings
health
disease,
potential
implications
for
targeted
therapies
advancements
dermatological
research.
Hence,
our
objective
is
provide
comprehensive
summary
available
knowledge
concerning
relationship
MALAT1.
OncoTargets and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 643 - 653
Published: Aug. 1, 2024
Ameloblastoma
(AB)
is
a
common
odontogenic
tumor
that
develops
in
the
mouth.
Despite
its
benign
nature,
AB
exhibits
significant
invasiveness
leading
to
metastasis
and
high
postoperative
recurrence
rates.
Studies
have
shown
relationship
between
occurrence
development
of
various
tumors
non-coding
RNA
(ncRNA).
NcRNA,
transcribed
from
genomes
mammals
other
complex
organisms,
are
often
products
alternative
splicing
processing
into
smaller
products.
MicroRNA
(miRNA),
circular
(circRNA),
long
(lncRNA)
main
types
ncRNA.
NcRNA
play
increasingly
roles
pathogenesis
human
cancers,
regulating
their
progression
as
oncogenes
or
suppressors.
They
involved
through
pre-mRNA,
transcriptional
regulation,
mRNA
stability,
protein
translation,
chromatin
remodeling
modification.
The
importance
ncRNA
has
received
attention
recent
years.
However,
biological
functions
mechanisms
remain
largely
unknown.
In
this
review,
we
not
only
explore
AB,
but
also
describe
envision
potential
functional
biomarkers
diagnosis.
particular,
highlight
miR-29a
molecular
marker
for
diagnosis
therapy.
As
promising
novel
therapeutic
targets,
need
further
study,
which
indispensable.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10210 - 10210
Published: Sept. 23, 2024
Curated
online
interaction
databases
and
gene
ontology
tools
have
streamlined
the
analysis
of
highly
complex
gene/protein
networks.
However,
understanding
disease
pathogenesis
has
gradually
shifted
from
a
protein-based
core
to
interactive
networks
where
non-coding
RNA
(ncRNA)
is
thought
play
an
essential
role.
As
current
based
predominantly
on
protein-level
information,
there
growing
need
analyze
with
ncRNA.
In
this
study,
we
propose
workflow
integrating
ncRNA
using
NPInter
V5.0
database.
To
validate
proposed
workflow,
analyzed
our
previously
published
curated
biomarker
datasets
for
hidden
susceptibility
processes
pharmacogenomics.
Our
results
show
novel
involvement
melanogenesis
in
psoriasis
response
biological
drugs
general.
Hyperpigmentation
been
observed
following
treatment
currently
indicated
drugs,
thus
calling
attention
research
as
psoriasis.
Moreover,
highlights
critically
evaluate
computed
interactions
within
demand
large
miRNA
blocks.
