Pretreatment with Kahweol Attenuates Sepsis‐Induced Acute Lung Injury via Improving Mitochondrial Homeostasis in a CaMKKII/AMPK‐Dependent Pathway DOI
Guorui Li,

Tinglv Fu,

Wei Wang

et al.

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(19)

Published: July 23, 2023

Scope It is well‐established that dysregulated mitochondrial homeostasis in macrophages leads to inflammation, oxidative stress, and tissue damage, which are essential the pathogenesis of sepsis‐induced acute lung injury (ALI). Kahweol, a natural diterpene extracted from coffee beans, reportedly possesses anti‐inflammatory protective properties. Herein, study investigates whether Kahweol can alleviate ALI explore underlying mechanisms. Methods results C57BL/6J mice intraperitoneally injected with lipopolysaccharide (LPS) for 12 h induce ALI. Pretreatment kahweol by gavage 5 days significantly alleviates pathological injury, accompanied shifting dynamic process mitochondria fission fusion, enhancing mitophagy, activating AMPK. To investigate molecular mechanisms, differentiated THP‐1 cells cultured medium containing prior LPS exposure, yielding consistent findings vivo results. Moreover, AMPK inhibitors abrogate above effects, indicating acts an AMPK‐dependent manner. Furthermore, explores how activates finds this mediated CamKK II. Conclusion attenuates via improving CaMKKII/AMPK‐dependent pathway may be potential candidate prevent

Language: Английский

Pyroptosis in inflammation-related respiratory disease DOI Creative Commons

Yuanyu Feng,

Min Li,

Xiaoting Yangzhong

et al.

Journal of Physiology and Biochemistry, Journal Year: 2022, Volume and Issue: 78(4), P. 721 - 737

Published: July 11, 2022

Abstract Pyroptosis is commonly induced by the gasdermin (GSDM) family and accompanied release of inflammatory cytokines such as IL-1β IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize roles mechanisms inflammation-related There are several pathways involved pyroptosis, canonical inflammasome-induced pathway, non-canonical caspase-1/3/6/7/GSDMB caspase-8/GSDMC caspase-8/GSDMD caspase-3/GSEME pathway. may be asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute injury (ALI), silicosis, hypertension (PH), tuberculosis (TB), which NLRP3 pathway mostly highlighted. contributes deterioration COPD, ALI, PH. In addition, has dual effects on cancer TB. Additionally, whether participates cystic fibrosis (CF) sarcoidosis or not largely unknown, though activation inflammasome found CF sarcoidosis. conclusion, play diseases, providing new therapeutic targets.

Language: Английский

Citations

101
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective DOI Creative Commons
Yifan Liu,

Renjie Pan,

Yuzhen Ouyang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

51
HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control DOI Creative Commons
Ning Li, Bohao Liu, Rui Xiong

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102746 - 102746

Published: May 20, 2023

Sepsis is one common cause of acute lung injury (ALI) and respiratory distress syndrome (ARDS), which closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying enzyme could affect chromatin structure transcriptional regulation. Here, we explored the effects HDAC3 type II alveolar epithelial cells (AT2) on lipopolysaccharide (LPS)-induced ALI shed light potential molecular mechanisms. We generated mouse model conditional knockout mice (Sftpc-cre; Hdac3f/f) AT2 roles barrier integrity were investigated LPS-treated AT2. The levels significantly upregulated tissues from sepsis deficiency not only decreased inflammation, apoptosis, oxidative stress, but also maintained integrity. Meanwhile, preserved mitochondrial quality control (MQC), evidenced by shift mitochondria fission into fusion, mitophagy, improved fatty acid oxidation (FAO). Mechanically, promoted transcription Rho-associated protein kinase 1 (ROCK1) In context LPS stimulation, ROCK1 elicited be phosphorylated (RhoA), thus disturbing MQC triggering ALI. Furthermore, found that forkhead box O1 (FOXO1) was factors ROCK1. directly acetylation FOXO1 its nuclear translocation Finally, inhibitor RGFP966 alleviated damage Altogether, sepsis-induced preserving via FOXO1-ROCK1 axis, provided a strategy for treatment

Language: Английский

Citations

46
Targeting immunometabolism against acute lung injury DOI Open Access

Li Ning,

Zou Shishi,

Bo Wang

et al.

Clinical Immunology, Journal Year: 2023, Volume and Issue: 249, P. 109289 - 109289

Published: March 12, 2023

Language: Английский

Citations

45
Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS DOI Creative Commons
Chang Liu, Kun Xiao, Lixin Xie

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 18, 2022

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical with high morbidity and mortality that poses major challenge in care medicine. The development of ALI/ARDS involves excessive inflammatory response, macrophage autophagy plays an important role regulating the response ALI/ARDS. In this paper, we review effects function, discuss roles ALI/ARDS, highlight drugs other interventions can modulate to improve understanding mechanism provide new ideas further research directions for treatment

Language: Английский

Citations

44
Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction DOI Creative Commons
Ri Wen, Yongping Liu,

Xiao-Xu Tong

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: July 29, 2022

Sepsis, a life-threatening organ dysfunction caused by dysregulated host response to infection, is leading cause of death in intensive care units. The development sepsis-associated (SAOD) poses threat the survival patients with sepsis. Unfortunately, pathogenesis sepsis and SAOD complicated, multifactorial, has not been completely clarified. Recently, numerous studies have demonstrated that pyroptosis, which characterized inflammasome caspase activation cell membrane pore formation, involved Unlike apoptosis, pyroptosis pro-inflammatory form programmed participates regulation immunity inflammation. Related shown sepsis, moderate promotes clearance pathogens, whereas excessive leads immune disorders SAOD. Additionally, transcription factors, non-coding RNAs, epigenetic modifications post-translational can directly or indirectly regulate pyroptosis-related molecules. Pyroptosis also interacts autophagy, NETosis, necroptosis. This review summarizes roles regulatory mechanisms As our understanding functions improves, new diagnostic biomarkers targeted therapies associated improve clinical outcomes appears promising future.

Language: Английский

Citations

41
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity DOI
Gregory Livshits, Alexander Kalinkovich

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101852 - 101852

Published: Jan. 13, 2023

Language: Английский

Citations

31
Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway DOI

Yu-qiong He,

Jiuling Deng,

Cancan Zhou

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 125, P. 111161 - 111161

Published: Nov. 9, 2023

Language: Английский

Citations

28
LL-37 improves sepsis-induced acute lung injury by suppressing pyroptosis in alveolar epithelial cells DOI
Quanzhen Wang, Wei Wen,

Lei Zhou

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111580 - 111580

Published: Feb. 3, 2024

Language: Английский

Citations

10
Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

Citations

2