Signal pathways involved in contrast-induced acute kidney injury DOI Creative Commons
Ke Deng,

Mingxin Pei,

Beibei Li

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking the third most prevalent cause of hospital-acquired injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated uncovering CI-AKI's pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, ferroptosis, improve prevention treatment. This review thoroughly analyzes pathways their interactions associated with CI-AKI, assesses impact various research models on pathway analysis, explores more targeted treatment approaches. Aims furnish robust theoretical foundation for molecular mechanisms underpinning clinical treatments.

Language: Английский

Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4 DOI
Gang Liu, Bowen Deng,

Luyao Huo

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 977, P. 176710 - 176710

Published: June 4, 2024

Language: Английский

Citations

8
Dahuang Chuanxiong Decoction Against Contrast-induced Nephropathy: Multi-omics, Crosstalk Between BNIP3-mediated Mitophagy and IL-17 Pathway DOI Creative Commons
Zhiyong Song, Jun Li, Xuezhong Gong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156416 - 156416

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury DOI Creative Commons
Ling Chen,

Yanyan Deng,

Jing Hu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration novel medicinal treatments for AKI management remains vital. Substances medicine food homology (SMFH), referring substances having characteristics both medicine, have been applied in China thousands years.They could be used daily diets body conditioning. Traditional Chinese (TCM), naturally derived components demonstrated effectiveness, presents distinctive benefits treatment. Numerous studies shown that SMFH TCM phytochemicals function satisfactorily nephroprotective effects a effect on alleviating as well complications. In this review, pathogenesis was illustrated. We concentrated against tried summarize underlying mechanisms various kinds AKI, highlighting crucial phytochemical prevention therapy. Besides, strategies globalization are analysed. This review comprehensively reveals exhibit promising potential intervention by targeting signal pathways targets, which would contribute AKI's cognition, preventive treatments, global promotion.

Language: Английский

Citations

0
Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023 DOI Creative Commons
Ling Chen, Jing Hu,

Jianrao Lu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 1, 2024

This study aims to conduct a detailed bibliometric and visual analysis of acute kidney injury (AKI) immune-related research conducted over the past two decades, focusing on identifying emerging trends key areas interest.

Language: Английский

Citations

1
Unveiling the Mysteries of Contrast-Induced Acute Kidney Injury: New Horizons in Pathogenesis and Prevention DOI Creative Commons
Zhong Wang, Qiuhan Wang, Xuezhong Gong

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 620 - 620

Published: Aug. 22, 2024

The utilization of contrast media (CM) in clinical diagnostic imaging and interventional procedures has escalated, leading to a gradual increase the incidence contrast-induced acute kidney injury (CI-AKI). Presently, scarcity effective pharmacological treatments for CI-AKI poses significant challenges management. Firstly, we explore pathogenesis this review. Beyond renal medullary ischemia hypoxia, oxidative stress, cellular apoptosis, inflammation, emerging mechanisms such as ferroptosis, release neutrophil extracellular traps (NETs), nitrosative which offer promising avenues management CI-AKI, are identified. Secondly, comprehensive strategy early prevention is introduced. Investigating risk factors associated with essential timely identification high-risk groups. Additionally, exploring sensitive biomarkers crucial diagnosis. A synergistic approach that combines these biomarkers, factors, disease prediction models enhances both accuracy efficiency processes. Finally, recent non-pharmacological interventions Cl-AKI. traditional focus on antioxidant N-acetylcysteine (NAC), look at active compounds from Chinese medicine, including tetramethylpyrazine (TMP), salvianolic acid B (Sal B), well preventive medications like amide (NACA), alprostadil, others, all showed potential benefits animal studies prevention. Furthermore, innovative strategies calorie restriction (CR), enhanced external counterpulsation (EECP), mesenchymal stem cell therapy highlighted providing fresh insights into Cl-AKI

Language: Английский

Citations

1
Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms DOI Open Access
Yi Zhao,

Jian‐Ye Song,

Ru Feng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3530 - 3530

Published: Oct. 18, 2024

As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more attention these days. It a tradition in many regions to intake medicinal herbal food for potential health benefits various organs systems including the kidney. Kidney diseases usually lack targeted therapy face irreversible loss of function, leading dialysis dependence. most important organ endogenous metabolite exogenous nutrient excretion, status kidney could be closely related daily diet. Therefore, rich antioxidative, anti-inflammation micronutrients are ideal supplements protection. Recent studies have also discovered its impact on "gut-kidney" axis.

Language: Английский

Citations

1
Research progress of traditional Chinese medicines in regulating acute kidney injury-related ferroptosis: a literature review DOI Creative Commons
Tao Peng, Mingquan Li

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Ferroptosis plays a significant role in the pathological mechanism of acute kidney injury (AKI) for many etiologies. The characteristics ferroptosis involve aspects, including iron metabolism, lipid and glutathione metabolism. In terms involves accumulation labile iron; peroxidation lipids, especially certain phospholipids; reduction reduced (GSH) levels, leading to decrease activity peroxidase 4 (GPX4). A lot traditional Chinese medicines (TCMs) have been reported protective effect against AKI, these TCMs shown close association with regulating ameliorating AKI. While mechanisms through which regulate associated AKI are intricate, their targets linked inhibition or regulation This article discusses some aspects ferroptosis, reviews research progress on AKI-related by TCMs.

Language: Английский

Citations

1
Innovative approaches beyond periprocedural hydration for preventing contrast-induced acute kidney injury DOI Open Access
Chun‐Han Cheng, Wen‐Rui Hao, Tzu‐Hurng Cheng

et al.

World Journal of Radiology, Journal Year: 2024, Volume and Issue: 16(9), P. 375 - 379

Published: Sept. 26, 2024

Contrast-induced acute kidney injury (CI-AKI) is a major concern in clinical practice, particularly among high-risk patients with preexisting renal and cardiovascular conditions. Although periprocedural hydration has long been the primary approach for CI-AKI prevention, recent advancements have led to development of novel approaches such as RenalGuard contrast removal systems. This editorial explores these emerging highlights their potential enhancing prevention. By incorporating latest evidence into health-care professionals can more effectively maintain function improve outcomes undergoing contrast-enhanced procedures.

Language: Английский

Citations

0
Signal pathways involved in contrast-induced acute kidney injury DOI Creative Commons
Ke Deng,

Mingxin Pei,

Beibei Li

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking the third most prevalent cause of hospital-acquired injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated uncovering CI-AKI's pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, ferroptosis, improve prevention treatment. This review thoroughly analyzes pathways their interactions associated with CI-AKI, assesses impact various research models on pathway analysis, explores more targeted treatment approaches. Aims furnish robust theoretical foundation for molecular mechanisms underpinning clinical treatments.

Language: Английский

Citations

0