Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 9, 2024
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future
Language: Английский
Citations
11Distinguishing features of depression in dementia from primary psychiatric disease
Discover Mental Health, Journal Year: 2024, Volume and Issue: 4(1)
Published: Jan. 4, 2024
Abstract Depression is a common and devastating neuropsychiatric symptom in the elderly patients with dementia. In particular, nearly 80% of Alzheimer’s Disease dementia experience depression during disease development progression. However, it unknown whether shares same molecular mechanisms as presenting primary psychiatric or occurs persists through alternative mechanisms. this review, we discuss how clinical presentation treatment differ between disease, focus on major depressive disorder. Then, hypothesize several that may be unique to such neuropathological changes, inflammation, vascular events. Finally, existing issues future directions for investigation
Language: Английский
Citations
9Understanding the Biological Relationship between Migraine and Depression
Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 163 - 163
Published: Jan. 30, 2024
Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely develop depressive disorder; this becomes even higher patients suffering from chronic or aura. This relationship bidirectional, since depression also predicts earlier/worse of migraine, increasing chronicity and, consequently, requiring healthcare expenditure compared alone. All these data suggest that may share overlapping biological mechanisms. Herein, review explores topic further detail: firstly, by introducing common epidemiological for comorbidity; secondly, focusing on providing cumulative evidence aspects, particular emphasis serotoninergic system, neuropeptides calcitonin-gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), substance P, neuropeptide Y orexins, sexual hormones, immune system; lastly, remarking future challenges required elucidate etiopathological mechanisms updated information regarding new key targets pharmacological treatment entities.
Language: Английский
Citations
9How inflammation influences psychiatric disease
World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(3), P. 342 - 349
Published: March 19, 2024
Recent studies highlight the strong correlation between infectious diseases and development of neuropsychiatric disorders. In this editorial, we comment on article “Anti-infective therapy durations predict psychological stress laparoscopic surgery quality in pelvic abscess patients” by Zhang et al , published recent issue World Journal Psychiatry 2023; 13 (11): 903-911. Our discussion highlighted potential consequences anxiety, depression, psychosis, which are all linked to bacterial, fungal, viral infections, relevant impact inflammation sequelae mental health as those observing after coronavirus disease 2019 pandemic. We focus specifically immune mechanisms triggered inflammation, primary contributor psychiatric complications. Importantly, pathophysiological such organ damage, post-injury infection-induced endocrine alterations, including hypocortisolism or autoantibody formation, significantly contribute chronic low-grade promoting emergence alterations susceptible individuals. As can have long-term effects patients, a multidisciplinary treatment plan avoid complications debilitating issues, it is crucial recognize address implications.
Language: Английский
Citations
9Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 104 - 104
Published: Jan. 15, 2025
Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of wide range brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) cause neuroinflammation, alter function, accelerate disease development. Despite progress understanding these pathways, effective medicines targeting are still limited. Traditional anti-inflammatory immunomodulatory drugs peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to central nervous system (CNS), blood-brain barrier (BBB) unwanted systemic effects. This review highlights developing treatment techniques modifying cytokine-driven focusing on advances that selectively target critical involved pathology. Novel approaches, cytokine-specific inhibitors, antibody-based therapeutics, gene- RNA-based interventions, sophisticated drug delivery systems like nanoparticles, show promise with respect lowering neuroinflammation greater specificity safety. Furthermore, developments biomarker discoveries neuroimaging improving our ability monitor responses, allowing more accurate personalized regimens. Preclinical clinical trial data demonstrate therapeutic potential tailored techniques. However, significant challenges remain, across BBB reducing off-target As research advances, creation personalized, cytokine-centered therapeutics has therapy landscape illnesses, giving patients hope better results higher quality life.
Language: Английский
Citations
1Exploring the Anxiolytic, Antidepressant, and Immunomodulatory Effects of Cannabidiol in Acute Stress Rat Models
Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4
Published: Jan. 21, 2025
Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis sativa, is believed to have anxiety-reducing and antidepressant effects. However, existing data are inconsistent, likely due variations in experimental designs, dosages, stress models. This study sought assess the impact of CBD on anxiety depression-like behaviors Wistar rats exposed acute cold stress, as well its pro- anti-inflammatory cytokines. Male were treated with (2.5, 5, or 10 mg/kg) vehicle for 14 days subjected behavioral tests, including elevated plus maze, social interaction, forced swim tests. Serum levels cytokines (IL-6, TNF-α, IL-1β, IL-10) analyzed post-experiment using ELISA. Results demonstrated dose-dependent anxiolytic effect CBD, significant improvements interaction reductions anxiety-like at 5 mg/kg. All doses decreased immobility test, suggesting Furthermore, selectively lowered IL-6 levels, key cytokine depression pathogenesis. These findings indicate that has properties, partially mediated by modulation inflammatory processes, particularly IL-6.
Language: Английский
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1List of Abbreviations and Acronyms
Published: Jan. 30, 2025
Language: Английский
Citations
0Dimensions and Implications of Cultural Identity
Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 60 - 87
Published: Jan. 30, 2025
Abstract Cultural identity is intersectional: It includes not only race and nationality but also socioeconomic class, occupation, religion, gender, age/generation, life stage. Culture usefully characterized dimensionally. Hofstede identified dimensions of individualism/collectivism, power distance, uncertainty avoidance, gender role differentiation, short-term/long-term orientation, indulgence/restraint. Trust in individuals institutions, as well social capital—structural, relational, instrumental, cognitive—moderate the emotional effects stress adversity. clinicians enables effective treatment. The expression depression mediated by cultural communication styles, with their high-context/low-context, direct/indirect, self-enhancing/self-effacing, elaborate/understated. Word choices metaphors—which vary culture—help identify depression, indicate its severity, reveal suicide risk. Details critical for accurate diagnosis treatment can be “lost translation.”
Language: Английский
Citations
0Seeing Depression Through A Cultural Lens
Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Abstract Seeing Depression through a Cultural Lens, the collaborative work of clinical neuroscientist and scholar comparative culture, examines effects cultural identity on epidemiology, phenomenology, narratives depression, bipolar spectrum, suicide. Culture is associated with emotional communication style, “idioms distress,” conception depression disorders, how people mood disorders might be stigmatized. It linked to structural factors—environmental, social, economic circumstances—that create or mitigate risk sometimes precipitate episodes illness, facilitate impede treatment. shapes depressed people’s willingness disclose acknowledge their condition seek care, relationships clinicians, acceptance rejection specific treatments. context essential understanding underlies motives for suicide, facilitating inhibiting factors, social acceptability death by availability lethal means self-harm. always intersectional—comprising elements related race ethnicity; gender; age, generation, life stage; education; class; occupation; migrant minority status; region residence; religious belief practice. Lens explores implications each these dimensions using salient concepts form sciences; memorable from literature, film, clinic; quantitative findings epidemiology psychometrics. offers readers framework culturally aware assessment management bipolarity, suicidal in individuals populations.
Language: Английский
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0Preface
Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. xv - xxii
Published: Jan. 30, 2025
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0