Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 558 - 558

Published: May 30, 2024

Mood disorders and substance use disorder (SUD) are of immense medical social concern. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, it is only relatively recently that the role glia these attracted attention. Detailed understanding glial functions devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contributions neurotrophic factors, neuroinflammation, gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes, synantocytes) phenotypic manifestation or SUD emphasized. addition, knowledge potential development therapeutics touched upon.

Language: Английский

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The interplay of gut microbiota, obesity, and depression: insights and interventions

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Oct. 30, 2024

Language: Английский

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Gut Microbiome and Symptom Burden in Obese and Non-Obese Women Receiving Chemotherapy for Breast Cancer

Biological Research For Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Purpose: Obese women with breast cancer experience high symptom burden, poor quality of life, and increased mortality compared to non-obese cancer. Obesity-related changes the bacteria gut, GI microbiome, may be one such mechanism for these differences in outcomes. The purpose this work is report burden microbiome composition between obese identify potential microbial influences severity. Methods: 59 (26 obese, 33 non-obese) provided reports using Memorial Symptom Assessment Scale stool samples 16S analysis week after receiving chemotherapy. were summarized examined based on obesity. Fecal was groups alpha-diversity (Shannon index), beta-diversity (Principal Coordinate Analysis weighted UniFrac distances), LASSO abundance bacterial species. Results: While high, it did not differ obesity status. Alpha- find significant obesity, but identified eight significantly enriched participants: Collinsella aerofacien, Prevotella 7, Coprobacillus cateniformis, Ruminococcus torques group, Agathobacter, Frisingicoccus, Roseburia inulinivorans, Monoglobus pectinilyticus. Conclusions: Identifying biologic mechanisms driving symptoms necessary development therapies reduce cancer-related burden. alter influence cancer, effects outweighed by chemotherapy gut.

Language: Английский

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Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

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Global research trends in the intestinal microflora and depression: bibliometrics and visual analysis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 25, 2025

In recent years, the relationship between gut microbiota and human health has garnered significant attention. Notably, potential connection mental issues, such as depression anxiety, emerged a new focal point for research. While some studies suggest possible link these factors, field remains in its early stages of development, there are notable methodological sample size limitations. This study aims to systematically summarize knowledge systems, research hotspots, development trends related intestinal microflora within context conducted search publications Web Science Core Collection (WOSCC) prior August 6, 2024. The selected literature was subsequently analyzed using VOSviewer (v.1.6.20), SCImago Graphica (v.1.0.39), CiteSpace (v.6.3.1). encompassed total 1,046 publications, demonstrating consistent increase annual publication volume. primary countries identified China United States, with contributions from institutions University California College Cork, among others. Keywords analysis highlighted high-frequency terms including "gut microbiota," "depression," "anxiety," revealed 10 keyword clusters along 20 strongest citation bursts keywords. focus shifted compositional role pathogenesis depression. Research on is growing, but still need greater collaboration authors across regions, more ongoing interaction communication further explore mechanisms action microbiota, develop microbiota-based interventions, facilitate translation findings into clinical practice.

Language: Английский

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The role of microbiome in gut-brain-axis dysbiosis causing depression: From mechanisms to treatment

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Impact of Depression on Health-Related Quality of Life in Ulcerative Colitis Patients—Are We Doing Enough? A Single Tertiary Center Experience

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 612 - 612

Published: April 6, 2025

Ulcerative colitis (UC) significantly impacts patients’ health-related quality of life (HRQOL). This study aimed to evaluate HRQOL and the factors affecting it, prevalence anxiety, depression alexythimia in patients with UC. cross-sectional included 248 UC (21 proctitis, 63 left-sided 164 extensive colitis). Data were collected using standardized self-administered questionnaires [a socio-demographic questionnaire, General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Toronto Alexithymia Scale (TAS-20) Short Inflammatory Bowel Disease Questionnaire (SIBDQ)]. Clinical data on remission status, extraintestinal manifestations, comorbidities use advanced therapies also collected. Hierarchical regression analysis variables predicting SIBDQ score was done. laboratory present 95.6% patients. The prevalences depression, anxiety alexithymia 44.7%, 34.3% 30.2%, respectively. There no differences PHQ-9, GAD-7 TAS-20 scores relation status. average 56.5. reported better compared symptomatic (p = 0.002). hierarchical showed that disease a higher influenced high. Remission high main related HRQOL.

Language: Английский

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Exploring the Characteristics of Gut Microbiota Associated with Depression via the Depression Assessment Scales

Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 35

Published: Nov. 27, 2024

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Interaction between Gut Microbiota and Medicinal Food Homology in Depression

Journal of Biosciences and Medicines, Journal Year: 2024, Volume and Issue: 12(11), P. 190 - 205

Published: Jan. 1, 2024

Language: Английский

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Adult neurogenesis and the microbiota-gut-brain axis in farm animals: underestimated and understudied parameters for improving welfare in livestock farming

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Nov. 27, 2024

Welfare in commercial livestock farming is becoming increasingly important current agriculture research. Unfortunately, there a lack of understanding about the neuronal mechanisms that underlie well-being on an individual level. Neuroplasticity hippocampus, subventricular zone (SVZ), olfactory bulb (OB) and hypothalamus may be essential regulatory components context farm animal behaviour welfare altered by providing environmental enrichment (EE). The importance pre-and probiotics as form EE microbiota-gut-brain axis (MGBA) has come under spotlight last 20 years, particularly contexts research into stress resilience. However, it could also system for farming. This review aims to present brief overview effects physiology animals briefly discusses literature behavioural flexibility, well inter-individual stress-coping styles their relationship welfare. Most importantly, we will summarise different forms neural plasticity animals, focusing neurogenesis various relevant brain regions. Furthermore, provide outlook connecting these neuroplasticity, stress, EE, MGBA measures modern farming, concentrating pigs.

Language: Английский

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