Maternal Immune Activation and Autism Spectrum Disorder: Complex Interactions and Therapeutic Possibilities DOI Open Access
Geir Bjørklund, Ramesa Shafi Bhat, Afaf El‐Ansary

et al.

International journal for autism challenges & solution., Journal Year: 2024, Volume and Issue: 1(1), P. 39 - 50

Published: April 19, 2024

This review examines the intricate association between maternal immune activation (MIA) and autism spectrum disorder (ASD), emphasizing impact of infections during pregnancy. Epidemiological studies link viral bacterial to an elevated risk ASD, revealing complex interplay environmental factors neurodevelopmental outcomes. Immunological mechanisms, including cytokine dysregulation neuroinflammation, involve key players such as interleukin-6 tumor necrosis factor-alpha, influencing fetal brain development ASD risk. Genetic interactions contribute individual susceptibility, with specific variants MIA's on Epigenetic modifications provide a molecular exposures, MIA, enduring changes. Recognizing critical periods neurodevelopment susceptible MIA is crucial. Long-term highlight consequences behavior cognition into childhood adolescence. Exploring potential therapeutic interventions, immunomodulatory strategies pregnancy, offers hope for mitigating Despite progress, knowledge gaps persist, motivating future research guided by emerging technologies interdisciplinary approaches unravel MIA-ASD relationship.

Language: Английский

High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP DOI Creative Commons
H. H. Andersen, Matilde Kanstrup Andersen, Krista Agathe Bossow

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106742 - 106742

Published: March 1, 2025

Language: Английский

Citations

0
Physiological roles of embryonic microglia and their perturbation by maternal inflammation DOI Creative Commons
Tatsuro Shimamura,

Masashi Kitashiba,

Kayo Nishizawa

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

The interplay between the nervous and immune systems is well documented in context of adult physiology disease. Recent advances understanding cell development have highlighted a significant interaction neural lineage cells microglia, resident brain macrophages, during developmental stages. Throughout development, particularly from embryonic to postnatal stages, diverse are sequentially generated, undergo fate determination, migrate dynamically their appropriate locations while maturing, establish connections with surroundings form circuits. Previous studies demonstrated that microglia contribute this highly orchestrated process, ensuring proper organization structure. These findings underscore need further investigate how behave function within broader framework neurodevelopment. Importantly, recent epidemiological suggested maternal activation (MIA), triggered by various factors, such as viral or bacterial infections, environmental stressors, other external influences, can affect neurogenesis circuit formation, increasing risk neurodevelopmental disorders (NDDs) offspring. Notably, many revealed fetal changes response MIA. Given essential roles vascular inappropriate disruption microglial may impair these critical processes, potentially leading abnormal This review highlights rodent models human shed light on behaviors multifaceted particular focus stage. Furthermore, drawing insights MIA models, explores disrupts disturbances ultimately contributing onset NDDs.

Language: Английский

Citations

0
Synergistic impact of early-life stress and prenatal immune activation on spatial memory and oxidative metabolism in rat cortico-limbic networks DOI Creative Commons
Saúl Sal-Sarria, Héctor González‐Pardo, Nélida M. Conejo

et al.

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: 219, P. 108060 - 108060

Published: May 1, 2025

Early life exposure to immune activation and stress are critical factors involved in the development of mental neurodevelopmental disorders adulthood. This study explored individual combined effects prenatal lipopolysaccharide-induced (LPS)-induced postnatal maternal separation on cognitive performance oxidative metabolism male Wistar rats. Using a 2 × factorial design, pregnant dams were exposed LPS or saline gestational day 15, offspring underwent from days 2-14. In adulthood, function was assessed using Morris Water Maze, regional brain energy evaluated quantitative histochemistry cytochrome c oxidase (CCO) prefrontal cortex, hippocampus, retrosplenial cortex. Rats both stressors demonstrated significant impairments spatial memory flexibility, supporting "two-hit" hypothesis early adversity, which posits that an adverse environmental event (first hit) with subsequent during developmental periods (second can significantly increase risk developing behavioral Accordingly, adult animals showed prolonged escape latencies decreased retention tasks. Concurrently, CCO activity markedly increased all measured regions, reflecting heightened metabolic demands. These changes consistent impaired hippocampal-prefrontal-retrosplenial network integration underlying key processes alterations such as attention. underscores synergistic these dysfunction, providing translational model better understand etiology disorders. The findings highlight importance addressing multiple interacting context adversity.

Language: Английский

Citations

0
Advancing in vitro assessment of iodide uptake inhibition: integrating a novel biotransformation pretreatment step DOI Creative Commons
Puja Kumari, Sebastian Lungu-Mitea, Jiří Novák

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Language: Английский

Citations

0
Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge DOI Creative Commons
Sara Manti,

Giulia Spoto,

Antonio Gennaro Nicotera

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 8, 2024

Brain development is a complex process that begins during pregnancy, and the events occurring this sensitive period can affect offspring's neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, last few decades, they have been related to numerous neuropsychiatric sequelae. viruses disrupt brain by directly invading fetal circulation through vertical transmission or inducing neuroinflammation maternal immune activation production of inflammatory cytokines. Influenza virus gestational infection has consistently associated with psychotic disorders, such as schizophrenia autism spectrum disorder, while recent pandemic raised some concerns regarding effects severe acute respiratory syndrome coronavirus 2 on outcomes children born affected mothers. In addition, emerging evidence supports possible role syncytial risk factor for adverse consequences. Understanding mechanisms underlying developmental dysfunction allows improving preventive strategies, early diagnosis, prompt interventions.

Language: Английский

Citations

3
Developmental functions of microglia: Impact of psychosocial and physiological early life stress DOI Creative Commons
Marissa A. Smail, Kathryn M. Lenz

Neuropharmacology, Journal Year: 2024, Volume and Issue: 258, P. 110084 - 110084

Published: July 17, 2024

Microglia play numerous important roles in brain development. From early embryonic stages through adolescence, these immune cells influence neuronal genesis and maturation, guide connectivity, shape circuits. They also interact with other glial structures, influencing the brain's supportive microenvironment. While this central role makes microglia essential, it means that life perturbations to can have widespread effects on development, potentially resulting long-lasting behavioral impairments. Here, we will focus of psychosocial versus physiological stressors rodent models. Psychosocial stress refers perceived threats lead axes activation, including prenatal stress, or chronic postnatal maternal separation resource scarcity. Physiological physical threats, infection, traumatic injury. Differing sources varied impacts microglia, are moderated by factors such as developmental age, region, sex. Overall, appear either 1) upregulate basal numbers activity throughout lifespan, while possibly blunting their responsivity subsequent stressors, 2) shift curve differential timing function, impacting critical periods they govern. Either could contribute dysfunctions occur after resolution stress. Exploring how different impact well multiple alter microglia's functions, deepen our understanding changes trajectory. This article is part Special Issue "Microglia".

Language: Английский

Citations

3
Maternal and fetal neurocognitive outcomes in preeclampsia and eclampsia; a narrative review of current evidence DOI Creative Commons
Emmanuel Kokori, Nicholas Aderinto, Gbolahan Olatunji

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Sept. 28, 2024

Language: Английский

Citations

3
Anti-inflammatory effects of antenatal administration of stem cell derived extracellular vesicles in the brain of rat fetuses with congenital diaphragmatic hernia DOI
Matisse Blundell, Fabian Doktor, Rebeca Lopes Figueira

et al.

Pediatric Surgery International, Journal Year: 2023, Volume and Issue: 39(1)

Published: Nov. 13, 2023

Language: Английский

Citations

8
Effects of Maternal SARS‐CoV‐2 Infection During Pregnancy on Fetal Development DOI
J. Li,

Jingwen Yao,

Zeyu Yang

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 92(2)

Published: Aug. 1, 2024

Abstract Background The severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) outbreak in 2019 has necessitated investigating its potential adverse effects on pregnancy outcomes and fetal development. Objective This study aimed to review the evidence impact of SARS‐CoV‐2 infection during outcomes. Method Study Literatures since COVID‐19 from PubMed Web Science were summarized this narrative review, show maternal Results can be transmitted vertically through placenta, both utero perinatally, affecting maternal–fetal immune interface placental function. Viral infections have been linked central nervous system development impairments disorders such as autism. Changes structure function respiratory, immune, visceral systems also reported. with increased risks stillbirth preterm birth. However, mechanisms involved remain unclear may include cytokine storms, macrophage mediation, genetic mutations, methylation, other epigenetic changes. Exploring protective antiviral treatment interventions animal clinical studies help improve Conclusion activates vertical transmission, short‐ long‐term development, including system. Future provide that inform reduce risk

Language: Английский

Citations

2
Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders DOI Creative Commons
Jun Zhou, Ping Yan, Wenxue Ma

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2