Xianlian Jiedu Decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155385 - 155385

Published: Jan. 27, 2024

Language: Английский

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Polysaccharides in fruits: Biological activities, structures, and structure-activity relationships and influencing factors-A review

Food Chemistry, Journal Year: 2024, Volume and Issue: 451, P. 139408 - 139408

Published: April 23, 2024

Language: Английский

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Heavy arch: from inflammatory bowel diseases to metabolic disorders

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage

Environment International, Journal Year: 2025, Volume and Issue: 195, P. 109258 - 109258

Published: Jan. 1, 2025

Nanoplastics (NPs) have attracted widespread attention owing to their presence in the body. Recent studies highlighted detrimental effects of NPs on digestive tract. However, no reported an association between exposure and colitis-associated cancer (CAC). An azoxymethane/dextran sodium sulfate-induced CAC model was used, polystyrene nanoparticles (PS-NPs) were selected for long-term exposure. Non-targeted metabolomics 16S rRNA sequencing used detect changes colonic metabolites gut microbes following PS-NPs A lipopolysaccharide (LPS)-treated cell (Caco-2) exposed investigate underlying molecular mechanism. Compared normal control group, mice group exhibited more tumor nodes reactive oxygen species (ROS), higher expression pan-CK Ki-67, severe DNA damage. revealed that altered abundance Allobaculum Lactobacillus, whereas metabolic analysis showed most significant enriched mostly fatty acid metabolism. Experiments LPS intervened Caco-2 cells led lipid peroxidation, oxidative stress, damage Caco-2. Exposure activated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling pathway both AOM/DSS mouse cellular model. Key proteins involved metabolism downregulated PS-NPs. The significantly inhibited by activation fenofibrate. disturbed induced via PI3K/AKT/mTOR promote progression. Inhibition is a therapeutic controlling PS-NP-induced CAC. Our study provides important reference prevention treatment from perspective environment enhances awareness necessity plastic control.

Language: Английский

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The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

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The Pentose Phosphate Pathway: From Mechanisms to Implications for Gastrointestinal Cancers

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 610 - 610

Published: Jan. 13, 2025

The pentose phosphate pathway (PPP), traditionally recognized for its role in generating nicotinamide adenine dinucleotide (NADPH) and ribose-5-phosphate (R5P), has emerged as a critical metabolic hub with involvements various gastrointestinal (GI) cancers. PPP plays crucial roles the initiation, development, tumor microenvironment (TME) of GI cancers by modulating redox homeostasis providing precursors nucleotide biosynthesis. Targeting enzymes their regulatory axis been potential strategy anti-GI cancer therapies. In this review, we summarize mechanisms enzymes, elucidate relationships between TME's elements, discuss therapeutic targeting

Language: Английский

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Specialized pro-resolving lipid mediators in gut immunophysiology: from dietary precursors to inflammation resolution

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Purpose of review This aims to examine recent research on the role specialized pro-resolving mediators (SPMs) in regulation gut immunophysiology. Recent findings Inflammatory bowel disease (IBD) is characterized by chronic inflammation gastrointestinal tract, driven disruptions intestinal barrier and an imbalance between host immune system microbiota. Dietary polyunsaturated fatty acids (PUFAs), especially ω-3 ω-6, are key regulators responses help maintain integrity barrier. These PUFAs serve as precursors SPMs, lipid that play a critical resolving inflammation. SPMs actively reprogram cells, promoting clearance cellular debris, reducing cytokine production, restoring tissue homeostasis without suppressing response. Emerging evidence indicates gut, strengthen function, modulate colitis colon cancer, influence microbiota composition. Summary The strongly supports central maintaining health organ function following inflammatory challenges. highlights potential therapeutic approaches target these pathways for both prevention treatment gut-related conditions.

Language: Английский

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Yeast-Inspired Orally-Administered Nanocomposite Scavenges Oxidative Stress and Restores Gut Immune Homeostasis for Inflammatory Bowel Disease Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Excessive oxidative stress, dysregulated immune homeostasis, and disruption of the intestinal epithelial barrier are crucial features inflammatory bowel disease (IBD). Traditional treatments focusing solely on inflammation resolution remain unsatisfactory. Herein, a yeast-inspired orally administered nanocomposite was developed. First, MD@MPDA core fabricated by integrating manganese dioxide (MnO2) nanozymes onto diallyl trisulfide (H2S prodrug)-loaded mesoporous polydopamine nanoparticles (MPDA). Then, yeast cell wall (YCW) chosen to encapsulate MD@MPDA, namely, YMD@MPDA. The β-glucan embedded in YCW shell not only protected from harsh gastrointestinal environment but also allowed targeting enrichment inflamed colon. Furthermore, M1 macrophages triggered intracellular GSH-responsive H2S release pathological microenvironment. effectively alleviated responses MnO2-mediated ROS-scavenging H2S-participated immunomodulation. synergistic action contributed macrophage mitochondrial function restoration M2 polarization suppressing NOX4 signaling p38 MAPK pro-inflammatory signaling. In mice model dextran sulfate sodium (DSS)-induced IBD, multipronged manner scavenging remodeling innate adaptive reshaping gut microbiota caused YMD@MPDA ameliorated restored functions. Overall, provides promising codelivery strategy antioxidative gas prodrugs for comprehensive management IBD.

Language: Английский

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The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4121 - 4121

Published: April 8, 2022

Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity mortality worldwide. Epidemiological data have shown that IBD patients at an increased risk for the development CRC. IBD-associated develops against background chronic inflammation oxidative stress, their products contribute to progression. Therefore, discovery novel drugs treatment intestinal is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used thousands years in traditional Chinese medicine. its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, antitumor effects. These pharmacological properties aid diseases. In this review, we discuss potential bioactive from addresses anti-inflammatory antioxidant properties. We also how mechanisms action these can influence effectiveness lead therapeutic effects on disorders.

Language: Английский

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Long-term trends in the burden of inflammatory bowel disease in China over three decades: A joinpoint regression and age-period-cohort analysis based on GBD 2019

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 7, 2022

Background To study the corresponding strategies to control inflammatory bowel disease (IBD), a comprehensive assessment of burden is required. Herein, we present long-term trends in IBD China over last three decades, as well its epidemiological features. Methods We characterized using GBD 2019 methods and results, based on prevalence, incidence, mortality, years lost (YLLs), lived with disability (YLDs), disability-adjusted life (DALYs) estimated DisMod-MR 2-1. also used joinpoint age-period-cohort (apc) analysis interpret characteristics compare them global prevalence trends. Results The age-standardized incidence mortality rates both sexes changed from 1.47 (95% CI: 1.24, 1.74) 3.01 2.59, 3.50) 0.86 0.59, 1.16) 0.30 0.24, 0.35) per 100,000 people 1990 2019. DALY rate decreased 24.47 17.88, 30.19) 13.10 10.29, 16.31) average annual percentage change (AAPC) for were 2.51 2.44, 2.57), 2.53 2.41, 2.66), −3.62 −3.85, −3.39). effects age, period, cohort differed. Conclusions increasing are contributed by reduction DALYs, compounded rise between China. will be major public health challenge, given country's large population base aging population.

Language: Английский

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