An analysis of trends in the burden of ischemic stroke caused by air pollution in China between 1990 and 2021 DOI Creative Commons

Zhengfeng Yu,

Xiuyun Zhang,

Xiaomei Fu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 28, 2025

This study evaluates the burden of ischemic stroke attributable to air pollution in China from 1990 2021, examines gender and age-specific differences, projects future disease trends 2022 2036. By analyzing impact on stroke, this aims provide insights for public health policies preventive measures. Utilizing data 2021 Global Burden Disease (GBD) study, research examined associated with China. To assess historical project 2036, Joinpoint regression modeling decomposition analysis were employed. These methods allow identifying significant trend changes disentangling contributions various factors. From observed a decline both age-standardized mortality rates (ASMR) disability-adjusted life years (DALY) attributed pollution. However, was slower among men than women, higher elderly males. Epidemiological transitions, including improved healthcare lifestyle changes, main drivers behind overall reduction burden. Projections indicate that over next 15 years, ASMR DALY (ASDR) women will continue decline, while is expected rise ASDR gradually increase before stabilizing. Elderly males are disproportionately affected by related pollution, highlighting critical issue. mitigate burden, it essential government implement targeted, gender- aimed at improving quality, enhancing access, promoting measures vulnerable populations, particularly men. findings underscore need integrated strategies reduce disparities address ongoing challenges posed

Language: Английский

Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study DOI Creative Commons
Xuejie Chen,

Xin Xiang,

Weitong Xia

et al.

Journal of Epidemiology and Global Health, Journal Year: 2023, Volume and Issue: 13(4), P. 725 - 739

Published: Sept. 1, 2023

Asia's inflammatory bowel disease (IBD) burden has rapidly increased recently, but the epidemiological trends in Asia remain unclear. We report IBD's incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) 52 Asian countries from 1990 to 2019.Data Global Burden of Disease 2019 were analyzed for IBD across countries, using metrics like mortality rates, DALY. The trend was assessed with Joinpoint APC methods. Decomposition frontier analyses examined factors behind case death changes. NORPRED forecasted morbidity 2044.From 2019, incidence prevalence Asia, while DALY decreased. East had highest increase burden. among 30-34 age group, peaking 45-49 group. In high-income regions, peak shifted younger groups. Decompose analysis showed population growth as primary factor increasing cases Asia. NORDPRED model predicted a continued over next 25 years.Between ASIR ASPR increased, ASMR ASDR Due aging, is expected rise years, particularly

Language: Английский

Citations

28
Global epidemiology of alcohol‐associated liver disease in adolescents and young adults DOI
Pojsakorn Danpanichkul, Vincent Chen,

Primrose Tothanarungroj

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(3), P. 378 - 388

Published: June 3, 2024

Summary Background and Aims The objective of the study was to analyse prevalence, incidence, death alcohol‐associated liver disease (ALD) among adolescents young adults globally, continentally, nationally, focusing on trends over time. Methods analysed data from Global Burden Disease (GBD) between 2000 2019. It examined ALD's in aged 15–29, segmented by region, nation, sociodemographic index. analysis utilised Joinpoint regression modelling calculate annual per cent change (APC) rate these parameters Results In 2019, there were 281,450 ALD prevalences, 18,930 incidences, 3190 deaths globally. From age‐adjusted prevalence 100,000 increased 25–29 age group (APC: +0.6%, p = 0.003), remained stable ages 20–24 ( 0.302) 15–19 0.160). Prevalence significantly (19‐fold increase) (2.5‐fold increase). rates all groups Africa Eastern Mediterranean region. Around three‐quarters countries territories experienced an increase incidence adults. Conclusion Over two decades, burden has emphasises importance public health policies aimed at reducing alcohol consumption preventing younger populations.

Language: Английский

Citations

16
Global, regional, and national burden of inflammatory bowel disease, 1990–2021: Insights from the global burden of disease 2021 DOI Creative Commons

Dao-po Lin,

Jin Yang, Xiaoxiao Shao

et al.

International Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 7, 2024

Language: Английский

Citations

15
The global burden of otitis media in 204 countries and territories from 1992 to 2021: a systematic analysis for the Global Burden of Disease study 2021 DOI Creative Commons
Guan‐Jiang Huang, Bao-Rui Lin, Pei-Shan Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Objectives This study aims to analyze the global burden of otitis media and predict future trends using data from Global Burden Disease 2021 (GBD 2021). Study design A cross-sectional analysis GBD results was conducted. Methods Age-standardized incidence rates (ASIR), age-standardized prevalence (ASPR), disability-adjusted life years (DALYs) (ASDR) were calculated. Trend conducted estimated annual percentage change (EAPC), Joinpoint regression, age-period-cohort, decomposition analyses. Future projections generated Bayesian age-period-cohort (BAPC) auto-regressive integrated moving average (ARIMA) models. Results The rose 322.1 million cases in 1992 391.3 2021, with ASIR increasing slightly 5345.09 5529.1 per 100,000 (EAPC: 0.11%). Despite this increase, ASPR decreased 1786.56 1593.74 -0.43%). DALYs increased 2.16 2.48 million; however, ASDR declined 37.68 32.54 −0.51%). Notably, low low-middle SDI regions showed significant disparities, higher ASIRs (up 5315.08 for males) but declining ASPR. Regionally, East Asia exhibited most substantial decline (−1.14%) (−1.22%), while Central Sub-Saharan Africa demonstrated stable ASDR. indicate a rising through 2036. Conclusion shows regional rate. Public health interventions have been effective regions, targeted efforts are needed further reduce media.

Language: Английский

Citations

1
Landscape and predictions of inflammatory bowel disease in China: China will enter the Compounding Prevalence stage around 2030 DOI Creative Commons
Bule Shao, Wenjing Yang, Qian Cao

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 25, 2022

This study aims to explore the epidemiological trends of inflammatory bowel disease (IBD) over past three decades in China and further predict IBD next 25 years.The prevalence, incidence, mortality, years life lived with disability (YLDs), lost (YLLs), disability-adjusted (DALYs), annual percentage changes above metrics from 1990 2019 were extracted Global Burden Disease Study 2019. The corresponding predicted.From 2019, cases raised 484 thousand [95% uncertainty interval (UI) 411-571] 427 (366-498) among males females, respectively. age-standardized incidence rate increased 1.72 per 100,000 population (1.44-2.05) 3.35 (2.88-3.88) 1.20 (1.02-1.42) 2.65 (2.29-3.08) females. highest occurred people aged 35-39 years. total YLDs attributed significantly increased, but YLLs showed a decreasing trend, resulting minor alterations DALYs. In years, would continue increase until plateau by 2030, IBD-related deaths also about 7.57 2044 despite mortality rate. Similar observed for both sexes, slight male predominance.Although is still low-endemic area IBD, prevalence dramatically decades. burden expected grow continuously due large base severe aging problem. estimated enter Compounding Prevalence stage around 2030.

Language: Английский

Citations

24
Potent Intestinal Mucosal Barrier Enhancement of Nostoc commune Vaucher Polysaccharide Supplementation Ameliorates Acute Ulcerative Colitis in Mice Mediated by Gut Microbiota DOI Open Access
Min Guo,

Dehai Xing,

Jin Wang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 3054 - 3054

Published: July 6, 2023

Ulcerative colitis (UC) is evolving into a global burden with substantially increasing incidence in developing countries. It characterized by inflammation confined to mucosa and recognized as an intestinal barrier disease. The microbiota plays crucial role UC pathogenesis. N. commune has long been appreciated healthy food supplement worldwide polysaccharides account for 60%. Here, we examined the amelioration of against acute mice induced DSS assessed mediating gut microbiota. An integrated analysis microbiome, metabolomics, transcriptomics fully elaborated it markedly enhanced mucosal function, including: relative abundance Akkermansia muciniphila, uncultured_bacterium_g__norank_f__Muribaculaceae, unclassified_g__norank_f__norank_o__Clostridia_UCG-014; decreasing microbiota-derived phosphatidylcholines thromboxane 2 levels mapped arachidonic acid metabolism; improving mucin2 biosynthesis secretion; enhancing ZO-1 occludin expression; reducing neutrophil infiltration; regulating level colitis-related inflammatory cytokines; involving immune function-associated signaling pathways. Further, mediation effect was evaluated administering cocktail antibiotics. In conclusion, our results demonstrated that predominantly reinforced microbiota-mediated confer protection exhibited dramatic prebiotic-like functions, providing alternative or complementary treatment UC.

Language: Английский

Citations

12
Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease DOI Open Access

Yanan Lu,

Xue Han

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1347 - 1347

Published: April 29, 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder, and its complex etiology makes prevention treatment challenging. Research on new drugs strategies currently focal point. Phenolic acids are widely present in plant-based diets have demonstrated the potential to alleviate colitis due their powerful antioxidant anti-inflammatory properties. In this review, we provide an overview of structures main dietary sources phenolic acids, encompassing benzoic acid cinnamic acid. Additionally, explore as nutritional therapy for preventing treating IBD. animal cell experiments, effectively IBD induced by drug exposure or genetic defects. The mechanisms include improving mucosal barrier function, reducing oxidative stress, inhibiting excessive activation immune response, regulating balance microbiota. Our observation points towards need additional basic clinical investigations derivatives novel therapeutic agents

Language: Английский

Citations

4
The Effect of Protein Nutritional Support on Inflammatory Bowel Disease and Its Potential Mechanisms DOI Open Access
Qingye Li, Jing Wang

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2302 - 2302

Published: July 17, 2024

Inflammatory bowel disease (IBD), a complex chronic inflammatory disorder that includes Crohn’s (CD) and Ulcerative Colitis (UC), has become globally increasing health concern. Nutrition, as an important factor influencing the occurrence development of IBD, attracted more attention. As most nutrient, protein can not only provide energy nutrition required by patients, but also help repair damaged intestinal tissue, enhance immunity, thus alleviate inflammation. Numerous studies have shown nutritional support plays significant role in treatment remission IBD. This article presents comprehensive review pathogenesis IBD analyzes summarizes potential mechanisms Additionally, it provides overview clinical effects its impact on complications. Research findings reveal demonstrates benefits improving symptoms, reducing risk complications, quality life patients. Therefore, is expected to new approach for

Language: Английский

Citations

4
Grape Processing Waste: Effects on Inflammatory Bowel Disease and Colorectal Cancer DOI Creative Commons
Lucas Fornari Laurindo, Rosa Direito,

Alda Maria Machado Bueno Otoboni

et al.

Food Reviews International, Journal Year: 2023, Volume and Issue: 40(1), P. 336 - 369

Published: Feb. 8, 2023

Inflammatory Bowel Diseases (IBD) are inflammatory conditions characterized by bowel disruption and the involvement of immune system can be associated with development colorectal cancer. Conventional therapeutic approaches based on administering drugs capable modulating response; however, many patients irresponsive to conventional therapies. Grapes largely used in producing wine, juice, jam, other products. However, waste from production process represents an environmental problem. On hand, grape by-products rich bioactive compounds such as proanthocyanidins, anthocyanins, phenolic acids, stilbenes, flavonols. These help prevention or treatment several IBD Grape promote remarkable effects reducing pro-inflammatory, pro-oxidative, proliferative actions CRC both vivo vitro. related improvement epithelial integrity, reduction Disease Activity Index, mucosal barrier reinforcement, induction strong chemopreventive actions, tumor incidence, cell proliferation.

Language: Английский

Citations

11
The trends of lung cancer burden in BRICS from 1990 to 2021 and its projection to 2035 DOI Creative Commons
Yifan Wang,

Jingwen Zhu,

Shaoqiang Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 3, 2025

Lung cancer has become the malignant tumor with highest morbidity and mortality in world. This study aims to analyze burden of lung risk factors associated BRICS from 1990-2021 project 2021-2035. The Global Burden Disease (GBD) 2021 database was searched collect incidence, prevalence, mortality, disability-adjusted life years (DALYs), BRICS. Trends were analyzed using Joinpoint 4.9.1.0, Bayesian age-period-cohort (BAPC) analyses performed R4.4.1 disease AAPC(average annual percentage change) EAPC(estimated average ASIR(age-standardized incidence), ASPR(age-standardized prevalence), ASMR(age-standardized mortality), ASDR(age-standardized year) for Brazil, Russia, Ethiopia less than 0. Egypt's AAPC EAPC ASIR, ASPR, ASMR, ASDR all greater 0 1990-2021, China's at top 2021. According BAPC projection Iran, South Africa will have a decreasing trend Egypt an increasing With exception Ethiopia, tier level 1 2 rest behavioral smoking factors, respectively. still heavy cancer, there are significant differences among At same time, many prevention control measures worth learning other developing countries.

Language: Английский

Citations

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