Metaproteomics and metabonomics reveal the metabolic dysfunction of gut microbiota in Tibetan Minipigs in Atherosclerosis DOI Creative Commons
Liye Shen, Jinlong Wang, Yongming Pan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Atherosclerosis is fundamental in the development of cardiovascular disease. The unhealthy dietary habits, high fat and cholesterol intake could change composition gut microbes metabolites which play a critical role atherosclerosis. However, few studies have systematically investigated metabolism In this study, we build an atherosclerosis model using Tibetan minipigs, then identified feces serum, explored functions microbiota by metaproteomics. We found that, feces, multiple signal pathways showed obvious metabolic dysfunction that influence abundance blood products. Several such as 3-dehydro-2-deoxyecdysone from metabolism, leukotriene B4 arachidonic acid indole-3-acetate 3-hydroxyanthranilate tryptophan 9,10-epoxyoctadecenoic linoleic 13(S)-HPOT linolenic were significantly increased blood. These partially increasing associated with inflammation contributes Our finding provide novel clues for studying on mechanism arteriosclerosis.

Language: Английский

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

Citations

237
Effects of dietary fibre on metabolic health and obesity DOI
Edward C. Deehan, Valentin Mocanu, Karen Madsen

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(5), P. 301 - 318

Published: Feb. 7, 2024

Language: Английский

Citations

27
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

Citations

20
Interkingdom signaling between gastrointestinal hormones and the gut microbiome DOI Creative Commons
Xinyu Zhao, Ye Qiu,

Lanfan Liang

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in health of host development diseases. As vital component intestinal microecosystem, influences synthesis release many through mechanisms such as modulating environment, producing metabolites, impacting mucosal barriers, generating immune inflammatory responses, releasing neurotransmitters. Conversely, exert feedback regulation on by nutrient absorption utilization, bacterial biological behavior composition. distributions are anatomically intertwined, close interactions crucial for maintaining homeostasis. Interventions leveraging have been employed clinical management metabolic diseases bowel diseases, bariatric surgery fecal transplantation, offering promising targets treatment dysbiosis-related

Language: Английский

Citations

2
Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway DOI Creative Commons
Zhenhui Chen, Huijuan Chen,

Wanwen Huang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 16, 2024

Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants with no specific treatments available. We aimed to identify the molecular mechanisms underlying NEC investigate therapeutic effects Bacteroides fragilis on NEC. Clinical samples infant feces, bile acid-targeted metabolomics, pathological staining, bioinformatics analysis, rat model, co-immunoprecipitation were used explore pathogenesis Taxonomic characterization salt hydrolase (bsh) gene, enzyme activity assays, 16S rRNA sequencing, organoids B. NEC-related intestinal damage. samples, models, vitro experiments revealed that total acid increased blood but decreased feces. Moreover, levels FXR other metabolism-related genes abnormal, resulting disordered metabolism Taurochenodeoxycholic accelerated taurodeoxycholate alleviated displayed bsh damage by restoring gut microbiota dysbiosis abnormalities inhibiting FXR-NLRP3 signaling pathway. Our results provide valuable insights into role Administering may substantially alleviate

Language: Английский

Citations

12
Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer DOI Open Access
Camelia Munteanu, Betty Schwartz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

Citations

10
Parasite infections: how inflammation alters brain function DOI
Isabela de Brito Duval,

Marcelo Eduardo Cardozo,

Jorge Lucas Nascimento Souza

et al.

Trends in Parasitology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Anxiety disorders and the gut microbiota: a bibliometric and visual analysis DOI Creative Commons

Linli Guo,

Qin Ding, Qing Li

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Introduction Anxiety disorder is a common mental illness, yet its specific mechanisms remain unclear. Recent research has revealed connection between gut microbiota and anxiety disorders. This study aims to assess the current global landscape, highlight topics of interest, explore future directions in field disorders microbiota. Methods We extracted review articles related from Web Science, covering period 2004 2023. used VOSviewer 1.6.18.0, Scimago Graphica, CiteSpace 6.2. R2 visualize contributions countries, institutions, journals, authors, citations, keywords this field. Result A total 1198 were included bibliometric analysis. Over past two decades, both publications citations have shown steady increase. China, United States, Canada top three countries terms publication output. John Cryan University College Cork had highest number citation impact area research. The journal Nutrients publications, while Brain Behavior Immunity most citations. Key themes recent years anxiety, microbiota, depression, stress, gut-brain axis, probiotics, all which are likely be important directions. Conclusion analysis key areas emerging trends, including risk factors, stressors, inflammatory responses, probiotics. These insights can guide researchers towards more comprehensive understanding advancements field, help shape facilitate identification new therapeutic targets for disorder, ultimately improving clinical outcomes.

Language: Английский

Citations

1
Higher gut Bacteroidetes and Actinobacteria population in early pregnancy is associated with lower risk of gestational diabetes in the second trimester DOI Creative Commons

Seyedeh Neda Mousavi,

Navid Momeni,

Hossein Chiti

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 3, 2025

Despite the association between gut dysbiosis and metabolic disorders, main bacterial phylum in first trimester of pregnancy that predisposes mothers to gestational diabetes mellitus (GDM) second is not clear around world. Three-hundred healthy women aged 18-40 years who were participated this cohort study followed screening time for GDM diagnosis (in 24-28 weeks pregnancy). Stool samples gathered trimester. was diagnosed based on International Association Diabetes Pregnancy Groups. In total, thirty with GDM. Controls (N = 60) selected from non-GDM participants matching terms pre-pregnancy weight, weight gain, dietary intake familial history diabetes. The dominant population determined 16SrRNA gene expression. Mothers lower Bacteroidetes Actinobacteria more susceptible (p < 0.001 p 0.001). Firmicutes ratio significantly higher than controls A significant negative correlation observed 0.001, 0.001) 0.004, 0.02) serum FBS, 1 h-PG 2 levels time. However, 0.003, 0.01) showed a positive FBS levels. at associated risk Higher fasting 1-h glucose intolerance

Language: Английский

Citations

1
Deciphering Microbial Carbohydrate Metabolism: Unveiling Mechanistic Insights Into Type 2 Diabetes DOI Creative Commons
Navin Kumar, Satish Kumar Sain, Bhavna Solanki

et al.

Advanced Gut & Microbiome Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The human gut, comprising the stomach, intestine, and colon, hosts a diverse host‐specific microbial community known as gut microbiota. symbiotic relationship between humans their microbiota is highly conserved has evolved over time, playing crucial role in maintaining overall health well‐being. Metagenomic metabolomic analyses have revealed pivotal of regulating body homeostasis, influencing various physiological processes ranging from metabolism to immune system. Several studies demonstrated that dysbiosis associated with severe clinical conditions, including Type 2 diabetes. Individuals diabetes exhibit distinct composition, characterized by reduced diversity an altered relative abundance certain bacterial species. This can result chronic low‐grade inflammation metabolic endotoxemia. also marked persistent inflammation, where inflammatory cytokines contribute impaired glucose insulin resistance. complex, necessitating further research elucidate underlying mechanisms develop effective therapies. review provides valuable insights into potential aspects diabetes, metabolism, resistance, inflammation. aim this article highlight importance therapeutic target for managing

Language: Английский

Citations

1