Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 23, 2024
Cannabinoid
hyperemesis
syndrome
presents
as
a
complex
of
symptoms
and
signs
encompassing
nausea,
vomiting,
abdominal
pain,
hot
water
bathing
behavior,
most
typically
in
heavy
cannabis
user.
Its
presentation
is
frequently
associated
with
hypothalamic-pituitary-adrenal
axis
activation
stress
weight
loss.
Recent
investigation
has
identified
five
statistically
significant
mutations
patients
distinct
from
those
frequent
users
who
lack
the
symptoms,
affecting
TRPV1
receptor,
two
dopamine
genes,
cytochrome
P450
2C9
enzyme
that
metabolizes
tetrahydrocannabinol,
adenosine
triphosphate-binding
cassette
transporter.
The
escalating
intake
high
potency
cannabis,
or
alternatively,
other
agonists
cannabinoid-1
receptor
including
synthetic
cannabinoids.
Some
develop
environmental
triggers
scents
foods
suggest
classical
conditioned
responses.
Various
alternative
“causes”
are
addressed
refuted
text,
exposure
to
pesticides,
neem
oil
azadirachtin.
Nosological
confusion
cannabinoid
arisen
cyclic
vomiting
syndrome,
whose
pathophysiology
clearly
distinct.
possible
utilization
non-intoxicating
antiemetic
components
for
treatment
addressed,
along
future
research
suggestions
relation
its
genetic
foundation
metabolomic
signatures.
Pharmacological Reviews,
Journal Year:
2025,
Volume and Issue:
77(2), P. 100019 - 100019
Published: Jan. 6, 2025
Gastroparesis
is
a
neurogastrointestinal
disorder
of
motility
in
which
patients
experience
symptoms
nausea,
vomiting,
bloating,
early
satiety,
postprandial
fullness,
upper
abdominal
discomfort
or
pain,
and
delayed
gastric
emptying
solids
based
on
scintigraphy
stable
isotope
breath
test
when
mechanical
obstruction
has
been
excluded.
Symptoms
gastroparesis
may
result
from
diverse
pathophysiological
mechanisms,
including
antroduodenal
hypomotility,
pylorospasm,
increased
accommodation,
visceral
hypersensitivity.
The
most
common
etiologies
are
idiopathic,
diabetic,
postsurgical,
less
frequent
causes
neurodegenerative
disorders
(Parkinson's
disease),
myopathies
(scleroderma,
amyloidosis),
medication-induced
(glucagon-like
peptide-1
agonists
opioid
agents),
paraneoplastic
syndrome.
This
review
addresses
pharmacologic
management
prokinetic
antiemetic
agents,
agents
targeting
the
pylorus,
effects
neuromodulators.
SIGNIFICANCE
STATEMENT:
characterized
by
without
with
numerous
gastrointestinal
symptoms,
nausea
vomiting.
involves
nutritional
support,
medications,
procedures.
only
Food
Drug
Administration-approved
medication
for
metoclopramide.
article
reviews
pharmacology
efficacy
all
classes
antiemetics
used
gastroparesis.
There
still
considerable
unmet
need
efficacious
medications
specifically
treatment
gastroparesis,
especially
refractory
cases.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1412 - 1412
Published: April 4, 2024
In
this
review,
we
discuss
the
potential
role
of
cannabis
and
cannabinoids
in
management
cancer-related
symptoms.
There
is
limited
evidence
demonstrating
effectiveness
cannabis-based
products
treating
pain
gastrointestinal
symptoms
such
as
nausea,
vomiting,
loss
appetite.
Regarding
treatment
insomnia
mood
disorders,
most
studies
looked
at
these
secondary
outcomes
with
mixed
results.
Cannabis-based
have
adverse
effects,
ranging
from
neuropsychiatric
to
systemic
effects
drug
interactions.
JAMA,
Journal Year:
2024,
Volume and Issue:
332(17), P. 1496 - 1496
Published: Oct. 10, 2024
This
JAMA
Patient
Page
describes
cannabinoid
hyperemesis
syndrome,
a
gastrointestinal
condition
associated
with
frequent
and
long-term
use
of
cannabis.
International Journal of Environmental Research and Public Health,
Journal Year:
2025,
Volume and Issue:
22(4), P. 633 - 633
Published: April 17, 2025
This
review
focuses
on
Cannabis
Hyperemesis
Syndrome
(CHS)
in
youth,
a
condition
linked
to
chronic
cannabis
use
and
characterized
by
cyclic
vomiting,
abdominal
pain,
dehydration.
The
objectives
were
explore
CHS
progression
youth
its
impact
health,
assess
current
treatment
strategies.
There
are
the
three
distinct
phases
of
CHS:
prodromal,
hyperemetic,
recovery.
During
prodromal
phase,
individuals
experience
early
morning
nausea
discomfort,
often
mistakenly
alleviated
continued
use.
hyperemetic
phase
is
marked
severe
dehydration,
complications
like
electrolyte
imbalances,
leading
potentially
serious
health
risks.
Temporary
relief
may
be
experienced
through
hot
showers
or
baths.
In
recovery
symptoms
gradually
resolve,
normal
eating
bathing
habits
return.
emphasizes
physical
psychological
impacts
highlighting
potential
for
misdiagnosis
importance
intervention.
It
stresses
need
targeted
educational
efforts
schools,
healthcare
settings,
public
campaigns
prevent
delayed
diagnosis
improve
outcomes.
Findings
underscore
increasing
provider
awareness
promoting
preventive
education.
also
advocates
further
research
into
pathophysiology
diagnostic
protocols
young
populations.
Pediatric Emergency Care,
Journal Year:
2025,
Volume and Issue:
41(5), P. 397 - 405
Published: April 30, 2025
Cannabis
remains
one
of
the
most
frequently
misused
substances
among
adolescents.
As
recreational
cannabis
has
proliferated
across
United
States,
cannabis-related
emergency
department
visits
have
increased.
hyperemesis
syndrome,
a
variant
cyclic
vomiting
emerged
as
recognized
but
poorly
understood
complication
chronic
use
subset
individuals.
syndrome
is
characterized
by
repeated
cycles
abdominal
pain,
nausea,
and
refractory
to
standard
antiemetics,
with
users
reporting
compulsive
hot
showers
mitigate
symptoms.
Treatment
modalities
include
intravenous
fluid
electrolyte
repletion,
topical
application
capsaicin,
antidopaminergics
(eg,
droperidol,
haloperidol).
