Clonal hematopoiesis in LGI1‐antibody encephalitis DOI Creative Commons
Soo Jean Shin,

Yoonhyuk Jang,

Soo Hyun Ahn

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(10), P. 2785 - 2791

Published: Aug. 28, 2024

Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1)‐antibody encephalitis (LGI1e), the major form of autoimmune (AE) presented with memory loss and faciobrachial dystonic seizure, commonly develops in aged population. Hematologic aging is often accompanied by clonal hematopoiesis (CH), a phenomenon which specific mutations accumulate, potentially leading to disorders or malignancies. Our research aimed investigate connection between indeterminate potential (CHIP) LGI1e. Methods Peripheral blood samples from consecutive LGI1e patients were collected analyzed for 24 CHIP using targeted gene sequencing. The results compared control dataset an ethnically matched health care cohort. Patient characteristics based on their status. Results A total 52 enrolled this study. Among them, three (5.8%) exhibited functional ASXL1 gene, one CHIP‐associated genes This frequency was significantly higher that cohort (1%, p = 0.015). Nevertheless, showed no difference clinical characteristics, laboratory results, immunotherapy outcomes. Interpretation high mutation analysis, may contribute underlying pathogenesis. Further needed determine its direct role development autoimmunity disease progression.

Language: Английский

Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms DOI Open Access
Pasquale Niscola, Valentina Gianfelici, Marco Giovannini

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1563 - 1563

Published: April 19, 2024

Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the stem cell compartment drive disease pathogenesis. Recent advancements genomic profiling have provided valuable insights into biological underpinnings MDSs and expanded therapeutic options, particularly for specific molecularly defined subgroups. This review highlights diagnostic principles, classification updates, prognostic stratification systems, novel treatments, which could inform future clinical trials enhance management adult MDS patients,

Language: Английский

Citations

7
Clonal hematopoiesis of indeterminate potential: recent developments and perspectives DOI
Meiqi Guo,

Yuan Li,

Baobing Zhao

et al.

Current Opinion in Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Purpose of review This encompasses the recently published information on clonal hematopoiesis indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in research CHIP risk factors related diseases, with purpose offering new insights to treat both hematologic nonhematologic disorders. Recent findings The majority studies have shown that is a common biological condition associated aging incidence increases age. pathophysiology blood diseases projected be significantly influenced by CHIP. Nevertheless, increasing expanded application cover such as cardiovascular, renal, liver, pulmonary diseases. Furthermore, fast advancement genetic testing technology preventive medicine, involvement variety disorders shows promise an essential target for preventing disease onset progression. Summary linked illnesses has significant influence individual's health outlook. Thus, identifying managing critical improving clinical results individuals concerned.

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases DOI Creative Commons
Hanzhang Wu,

Jiahe Wei,

Yuefeng Yu

et al.

Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related expansion blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate association between CHIP and established autoimmune diseases. We analyzed baseline data from 456,692 UK Biobank participants available whole-exome sequences. The primary outcome was 19 disorders. Associations among any (variant allele fraction ≥2%), large clones ≥10%), gene-specific subtypes incidence diseases were assessed using Cox regression. Mediation analysis performed explore role inflammation in link identified 17,433 11,970 at baseline. Participants 44% 43% higher risk for Crohn's disease, 25% 33% psoriasis, 13% 14% rheumatoid arthritis, 35% 55% vasculitis, respectively. status increased levels inflammatory markers, including white cell, platelets, neutrophils, neutrophil-to-lymphocyte ratio, overall mediation ratios 16.3% 7.1% 23.2% 7.2% vasculitis. an incident multiple diseases, potentially mediated elevated levels. Future research needed clarify mechanisms underlying these associations interventions reduce risk.

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID) DOI Creative Commons

Attila Kállai,

Anna Ungvari,

Dóra Csabán

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential and risk of immune thrombocytopenia DOI
Qianwei Liu, Tove Wästerlid,

Karin E. Smedby

et al.

Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) might contribute to the pathogenesis immune thrombocytopenia (ITP) through dysfunction or impairment megakaryopoiesis and platelet formation. However, little is known about subsequent risk ITP among individuals with CHIP. Objective To investigate Methods We investigated association CHIP by a prospective cohort study, including 466,064 participants in UK Biobank, during 2006 2022. was ascertained based on data whole exome sequencing. Incident identified inpatient hospital records death register. Cox regression models were utilized estimate associated also performed subgroup analyses mutations ( DNMT3A , TET2 ASXL1 SRSF2 JAK2 ). Results The study included 14,466 451,598 without CHIP, respectively. 34 390 cases group reference group, an increased (hazard ratio [HR] 2.33, 95% confidence interval [CI]: 1.64–3.32). Subgroup analysis revealed that heightened greatest mutation (HR 54.31, CI: 17.39–169.59), followed 20.11, 8.27–48.87), 4.00, 2.34–6.83), 1.95, 1.16–3.27) mutation. Conclusion being diagnosed ITP, particularly for These findings call clinical awareness

Language: Английский

Citations

0
Clonal hematopoiesis DOI
Jaroslaw P. Maciejewski

Seminars in Hematology, Journal Year: 2024, Volume and Issue: 61(1), P. 1 - 2

Published: Feb. 1, 2024

Language: Английский

Citations

1
Clonal hematopoiesis in LGI1‐antibody encephalitis DOI Creative Commons
Soo Jean Shin,

Yoonhyuk Jang,

Soo Hyun Ahn

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(10), P. 2785 - 2791

Published: Aug. 28, 2024

Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1)‐antibody encephalitis (LGI1e), the major form of autoimmune (AE) presented with memory loss and faciobrachial dystonic seizure, commonly develops in aged population. Hematologic aging is often accompanied by clonal hematopoiesis (CH), a phenomenon which specific mutations accumulate, potentially leading to disorders or malignancies. Our research aimed investigate connection between indeterminate potential (CHIP) LGI1e. Methods Peripheral blood samples from consecutive LGI1e patients were collected analyzed for 24 CHIP using targeted gene sequencing. The results compared control dataset an ethnically matched health care cohort. Patient characteristics based on their status. Results A total 52 enrolled this study. Among them, three (5.8%) exhibited functional ASXL1 gene, one CHIP‐associated genes This frequency was significantly higher that cohort (1%, p = 0.015). Nevertheless, showed no difference clinical characteristics, laboratory results, immunotherapy outcomes. Interpretation high mutation analysis, may contribute underlying pathogenesis. Further needed determine its direct role development autoimmunity disease progression.

Language: Английский

Citations

0