Domino‐Redox Reaction Induced by An Electrochemically Triggered Conformational Change DOI Creative Commons
Takashi Harimoto,

Tomoki Tadokoro,

Soichiro Sugiyama

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 136(1)

Published: Nov. 16, 2023

Abstract The concept of a domino‐type reaction has been applied in wide range fields such as synthetic organic chemistry, material engineering, and life science. To extend the domino to redox we designed synthesized dimeric quinodimethane (QD) with nonplanar dithiin spacer. domino‐redox properties can be activated by raising temperature, based on thermally equilibrated twisted conformation QD, which higher HOMO level that is more readily oxidized. After one QD unit oxidized (trigger), steric repulsion electronic interaction between electrophores make neighboring adopt (domino process), facilitates following oxidation. Thus, was achieved for first time change due drastic molecular conformation.

Language: Английский

Recent Developments in Enantioselective Domino Reactions. Part A: Noble Metal Catalysts DOI

Hélène Pellissier

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(5), P. 620 - 681

Published: Jan. 17, 2023

Abstract This review updates the field of enantioselective domino reactions promoted by chiral catalysts derived from noble metals, including palladium, silver, rhodium, ruthenium, iridium and gold, published since beginning 2019. It illustrates how much a diversity these allow unprecedented asymmetric many types to be achieved with excellent enantioselectivity, giving direct access wide variety complex molecules. magnified image

Language: Английский

Citations

22

Enantioselective Synthesis of Spiro Heterocyclic Compounds Using a Combination of Organocatalysis and Transition‐Metal Catalysis DOI Creative Commons
Martin Kamlar, Michal Urban, Ján Veselý

et al.

The Chemical Record, Journal Year: 2023, Volume and Issue: 23(7)

Published: Jan. 26, 2023

Abstract Over the last ten years, combination of organocatalysis with transition metal (TM) catalysis has become one most important toolboxes used for synthesizing optically pure compounds containing chiral quaternary centers, including spiro heterocyclic molecules. The dominant method in enantioselective synthesis based on synergistic includes aminocatalysis and NHC catalysis, as already established covalent organocatalytic strategies. Another area widely combined TM producing enantiomerically enriched is non‐covalent dominated by phosphoric acids, thiourea, squaramide derivatives. This review article aims to summarize methods constructing spirocyclic heterocycles a catalysis.

Language: Английский

Citations

16

Recent Developments in Enantioselective Domino Reactions. Part B: First Row Metal Catalysts DOI

Hélène Pellissier

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(6), P. 768 - 819

Published: Jan. 17, 2023

This review updates the field of enantioselective domino reactions promoted by chiral catalysts derived from first row metals, such as zinc, iron, copper, scandium, nickel, cobalt, titanium, chromium and magnesium special case, published since beginning 2019. It illustrates how much a diversity these allow an impressive range novel highly many types to be achieved, providing one-pot access very complex functionalized molecules simple starting materials.

Language: Английский

Citations

14

Catalytic Stereoselective Multicomponent Reactions for the Synthesis of Spiro Derivatives: Recent Progress DOI

Divyang M. Patel,

Paras J. Patel,

Hitendra M. Patel

et al.

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(46)

Published: Nov. 16, 2022

Abstract Spiro derivatives are important scaffolding substances found in many natural products and pharmaceuticals. In the last decade, numerous new approaches based on multicomponent reactions have been explored for selective efficient development of spiro using various organocatalytic transition metal‐based catalytic systems. This Review discusses pioneering advances field stereoselective preparation derivatives. These include Michael cascade cyclization reactions, cycloadditions, diastereoselective miscellaneous synthesis spiro‐hetero/carbocycles. Advances decade made it possible to synthesize compounds with good excellent stereoselectivity under appropriate reaction conditions. However, achieving high regioselectivity several described remains a challenge. Organocatalysts transition‐metal‐based catalysts play crucial role this milestone. Proposed mechanisms supporting evidence highlighted Review. The progress is immense. expected that synthetic methods will soon be developed can widely used spiro‐heterocycles/carbocycles.

Language: Английский

Citations

20

Adventures in the Chemistry of Multicomponent and Domino Reactions DOI Creative Commons
Peter Langer

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(24)

Published: March 19, 2024

Abstract The present personalized account summarizes various cyclization reactions, including multicomponent and domino processes, which are directed towards the synthesis of complex heterocyclic products. Domino Knoevenagel/hetero‐Diels‐Alder reactions provide a annulated quinol‐2‐ones. combination Knoevenagel with [3+2] cycloadditions nitrogen ylides afford spiroheteriocyclic Knoevenagel/enamine result in formation condensed purine analogues. Formal [3+3] cyclizations pyridinium salts allow for rapid assembly bridged systems include employment thioxindoles cyclohexane‐1,3‐diones as dinucleophilic building blocks. formal fluoroaroyl chlorides, such 2‐fluorobenzoyl chlorides 2‐chloropyridine‐3‐carboxylic chloride, give rise to benzothiophenes. enamines diimines triazines analogues by [4+2]/retro [4+2] reactions. 2,4,6‐tris(trifluoromethyl)‐1,3,5‐triazine 1,3‐bis(silyloxy)‐1,3‐butadienes afford, depending on conditions, 2,6‐bis(trifluoromethy)pyrid‐4‐ones or triazaadamantanone derivatives. Heating 2‐ethynylpyridines electron‐rich dienes afforded 2‐(2‐methoxyphenyl)pyridines process. reaction enones indolizines cyclization. trifluoromethyl‐substituted 1,3‐diketones lithiated alkynes 3‐hydroxy‐pent‐4‐yn‐1‐ones. [5+1] latter urea pyridines. Pd catalyzed 2,3‐dihalopyridines imines series regioisomeric 4‐ 7‐azaindoles.

Language: Английский

Citations

4

The literature of heterocyclic chemistry, part XXII, 2022 DOI
Галина А. Газиева, Yu. B. Evdokimenkova, N. O. Soboleva

et al.

Advances in heterocyclic chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Domino-Redox Reaction Induced by a Conformational Change Based on Dithiin Bisquinodimethane Skeleton DOI
Takashi Harimoto

Springer theses, Journal Year: 2025, Volume and Issue: unknown, P. 111 - 146

Published: Jan. 1, 2025

Language: Английский

Citations

0

Research Advances in Electrochemical Synthesis of Spirocyclic Skeleton Compounds DOI
Mu‐Xue He, Ying‐Ming Pan, Qian Wang

et al.

Synthesis, Journal Year: 2023, Volume and Issue: 55(18), P. 2873 - 2895

Published: Jan. 24, 2023

Abstract Spirocyclic compounds have attracted the interest of synthetic chemists because their unique ring systems and utility in drug discovery. Many natural containing spirocyclic moieties skeleton are effective pharmaceuticals. For many redox processes, electroorganic synthesis is considered an environmentally friendly method, since use reagents with significant toxicity replaced by electric current, so amount waste often greatly reduced. Therefore, this review summarizes construction a via electrochemical strategies 2000. 1 Introduction 2 Electrochemically Mediated Synthesis Spirocyclopropanes 3 Spirooxindoles 4 Spirodienones 5 Other Heterospirocycles 6 Conclusion

Language: Английский

Citations

10

Visible-Light Organophotoredox-Mediated [3 + 2] Cycloaddition of Arylcyclopropylamine with Structurally Diverse Olefins for the Construction of Cyclopentylamines and Spiro[4.n] Skeletons DOI
Zhengshan Luo,

Bowen Cao,

Tianhang Song

et al.

The Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 87(22), P. 15511 - 15529

Published: Nov. 1, 2022

We developed a visible-light-mediated [3 + 2] cycloaddition of arylcyclopropylamine with structurally diverse olefins using QXPT-NPh as highly efficient organic photoredox catalyst. first achieved the use various alkyl-substituted alkenes in intermolecular cycloadditions cyclopropylamine. also general and strategy for construction cyclopentane-based spiro[4.n] skeletons 1,3-difunctional groups, which broadly exist natural products synthetic molecules. Furthermore, we proposed hydrogen-bond mode between photocatalyst QXPT-NPh.

Language: Английский

Citations

12

Recent Developments in Asymmetric Nazarov Reactions DOI

Hélène Pellissier

Current Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(10), P. 757 - 776

Published: April 17, 2024

Abstract: The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones under influence strong acids. prevalence five-membered carbocycles in a multitude natural and bioactive products has triggered an intense development efficient methods for their construction. In particular, asymmetric versions are achieved by using either chiral auxiliary or catalyst, which can be organocatalyst, metal multicatalytic system. This review aims to update field reactions published since 2017. It is divided four sections, dealing successively with auxiliaries, organocatalytic enantioselective reactions, metal/boron-catalyzed reactions. Each section subdivided simple Nazarov-based domino/tandem have allowed numerous more complex functionalized molecules synthesized one-pot procedures.

Language: Английский

Citations

2