Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 17, 2023

The past two decades have witnessed telemedicine becoming a crucial part of health care as method to facilitate doctor-patient interaction. Due technological developments and the incremental acquisition experience in its use, telemedicine’s advantages cost-effectiveness has led it being recognised specifically relevant diabetology. However, pandemic created new challenges for healthcare systems rate development digital services started grow exponentially. It was soon discovered that COVID-19-infected patients with diabetes had an increased risk both mortality debilitating sequelae. In addition, observed this higher could be attenuated primarily by maintaining optimal control patient’s glucose metabolism. As opportunities actual physical visits became restricted, provided most convenient opportunity communicate maintain delivery care. wide range experiences provision during several excellent strategies regarding applicability across whole spectrum continuation these is likely benefit clinical practice even after crisis over.

Language: Английский

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The prevalence of long COVID in people with diabetes mellitus–evidence from a UK cohort

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 71, P. 102607 - 102607

Published: April 17, 2024

BackgroundIt was apparent from the early phase of SARS-CoV-2 virus (COVID-19) pandemic that a multi-system syndrome can develop in weeks following COVID-19 infection, now referred to as Long COVID. Given people living with diabetes are at increased risk hospital admission/poor outcomes infection we hypothesised they may also be more susceptible developing We describe here prevalence COVID when compared matched controls Northwest UK population.MethodsThis retrospective cohort study who had recorded diagnosis type 1 (T1D) or 2 (T2D) were alive on 1st January 2020 and proven infection. used electronic health record data Greater Manchester Care Record collected 16th September 2023, determined T1D T2D vs individuals without (non-DM).FindingsThere 3087 14,077 non-diabetes 29,700 119,951 controls. For T1D, there lower proportion and/or referral service 0.33% 0.48% for The In 0.53% 1:3 0.54%. T2D, differences by sex comparison between males their controls, 0.46%.vs 0.54% (0.008). When considering LC females higher 0.61% (0.007). not different. patients older younger age reduced (OR 0.994 [95% CI) [0.989, 0.999]). minor increase 1.179, 95% CI [1.002, 1.387]). Presence body mass index (BMI) associated an 1.013, [1.001, 1.026]). estimated general population based practice coding (not self-reported) this 0.5% prior acute diagnosis.InterpretationRecorded prevalent men than non-T2D opposite seen women, rates being similar women. Younger age, female BMI all greater likelihood taken individual variables. There remains imperative continuing awareness differential symptomatic presentation context previous infection.FundingThe time co-author RW supported NIHR Applied Research Collaboration (NIHR200174) Biomedical Centre (NIHR203308).

Language: Английский

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Cross-Talk of NADPH Oxidases and Inflammation in Obesity

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1589 - 1589

Published: Aug. 9, 2023

Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental clinical studies have shown increased oxidative stress inflammation linked to obesity. NADPH oxidases are sources of reactive oxygen species in the system metabolically active cells organs. An impaired balance due formation reduced antioxidative capacity contributes pathophysiology diseases as pathomechanism cardiometabolic Non-alcoholic fatty liver disease particularly characterized by inflammation. In recent years, COVID-19 infections also infected tissues. Increasing evidence supports idea an severe complications after COVID-19. this review, we discuss role models obesity, diseases, potential therapeutic strategies.

Language: Английский

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Insulin and Metformin Administration: Unravelling the Multifaceted Association with Mortality across Various Clinical Settings Considering Type 2 Diabetes Mellitus and COVID-19

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 605 - 605

Published: March 7, 2024

Due to the molecular mechanisms of action antidiabetic drugs, they are considered be effective in treatment both COVID-19 and post-COVID-19 syndromes. The aim this study was determine effect administering insulin metformin on mortality patients with type 2 diabetes (T2DM) symptomatic use logistic regression models. association between death weak could not included multivariate model. However, interaction drugs other factors, including remdesivir low-molecular-weight heparin (metformin), age hsCRP (insulin), modulated odds death. These interactions hint at multifaceted (anti-/pro-) associations death, depending patient’s characteristics. In model, RDW-SD, adjusted treatment, age, sex K+, associated among T2DM. With a 15% increase risk increased by 87.7%. This preliminary provides foundations for developing further, more personalized models assess T2DM patients, as well identifying an due COVID-19.

Language: Английский

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Risk Factors Associated with Post-COVID-19 Conditions Among Diabetes Patients in the United Arab Emirates

Journal of Epidemiology and Global Health, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 20, 2025

Language: Английский

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Physical activity level one year following admission to the intensive care unit for COVID-19

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

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Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(1), P. e1011776 - e1011776

Published: Jan. 23, 2024

Introduction B-cells are essential components of the immune system that neutralize infectious agents through generation antigen-specific antibodies and phagocytic functions naïve memory B-cells. However, B-cell response can become compromised by a variety conditions alter overall inflammatory milieu, be due to substantial, acute insults as seen in sepsis, or those produce low-level, smoldering background inflammation such diabetes, obesity, advanced age. This dysfunction, mediated cytokines Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α), increases susceptibility late-stage sepsis patients nosocomial infections incidence severity recurrent infections, SARS-CoV-2, with chronic conditions. We propose modeling dynamics aid investigation their responses different levels patterns systemic inflammation. Methods The Immunity Agent-based Model (BCIABM) was developed integrating knowledge regarding B-cells, short-lived plasma cells, long-lived regulatory along various differentiation pathways cytokines/mediators. BCIABM calibrated reflect physiologic behaviors to: 1) mild antigen stimuli expected result sensitization effective memory, 2) severe challenges representing substantial during previously documented studies on behavior septic patients. Once calibrated, used simulate repeat states low, inflammation, implemented low IL-6 TNF-α often responsiveness were evaluated validated comparing Veteran’s Administration (VA) patient cohort COVID-19 infection known have higher comorbidities. Results successfully able reproduce appropriate development exposure, well immunoparalysis Simulation experiments then revealed significantly decreased increased, reproducing data VA population. Conclusion proved useful dynamically mechanisms function reproduced across range exposures statuses. These results elucidate previous demonstrating similar negative correlation between positing an established conserved mechanism explains dysfunction wide phenotypic presentations.

Language: Английский

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Impact of COVID-19 on preexisting comorbidities

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown, P. 215 - 258

Published: Jan. 1, 2025

Language: Английский

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Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 656 - 656

Published: Feb. 12, 2025

Long COVID has been associated with increased cardiovascular risk and chronic low-grade inflammation, raising concerns about its long-term metabolic consequences. Given that the Mediterranean diet (MD) shown beneficial effects on factors inflammation in various populations, it is important to explore potential impact individuals COVID. Therefore, aim determine association of MD (CVRF) syndrome (MetS) Caucasian subjects diagnosed Cross-sectional study, 305 were included following WHO criteria. Adherence was evaluated MEDAS (Mediterranean Diet Screener) 14 items used Prevention study (PREDIMED study). The criteria considered diagnose MetS blood pressure, glycemia, triglycerides, HDL cholesterol, waist circumference. Other CVRFs tobacco consumption, total LDL body mass index, baseline uric acid levels. between CVRF number components analyzed using multiple regression models multinomial regression. mean age 52.75 ± 11.94 years (men 55.74 12.22 women 51.33 11.57; p = 0.002), (68% women). questionnaire 7.76 2.37. presented 23.6% (39.8% men 15.9% < 0.001). In analysis, after adjusting for average time from acute COVID-19 infection date inclusion this score showed a negative (β -0.295; 95% CI: -0.496 -0.093), BMI -0.049; -0.096 -0.002), -0.210; -0.410 -0.010), circumference (WC) -0.021; -0.037 -0.003) positive cholesterol -0.018; 0.001 -0.037). findings suggest higher scores are lower levels acid, fewer components, smaller circumference,

Language: Английский

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The Role of Glycemic Control in Inflammation Markers and Clinical Outcomes in Type 2 Diabetes Patients with Severe COVID-19

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 886 - 886

Published: April 6, 2025

Background and Objectives: Patients with type 2 diabetes mellitus (T2DM) are at a heightened risk of adverse outcomes from Coronavirus Disease 2019 (COVID-19). However, the influence glycemic control on systemic inflammation clinical severity remains incompletely understood. This study aimed to compare inflammatory markers, composite scores, between T2DM patients COVID-19 who had well-controlled (hemoglobin A1c < 7%) versus those poorly controlled ≥ 7%). Methods: We retrospectively reviewed 181 adult severe admitted tertiary hospital January 2022 December 2023. were divided into two groups: (n = 117) 64) T2DM. Baseline demographics, comorbidities, laboratory parameters (C-reactive protein, interleukin-6, ferritin, neutrophil lymphocyte counts, platelets, calculated indices such as neutrophil-to-lymphocyte ratio [NLR] immune-inflammation index [SII]) collected. Composite scores (APACHE II, CURB-65, NEWS) (ICU admission, mechanical ventilation, mortality, length stay) compared. Statistical tests used included Student’s t-test or Mann–Whitney U for continuous variables chi-square categorical variables, p 0.05 deemed significant. Results: The groups did not differ significantly in age duration (p 0.40 0.75, respectively). exhibited higher markers (mean CRP 93.4 mg/L vs. 78.6 mg/L, 0.002; IL-6 64.2 pg/mL 52.8 pg/mL, 0.004) elevated II 16.8 14.1, 0.001). Poor was associated ICU admissions (39.1% 22.2%, 0.02) mortality (14.1% 6.0%, 0.05). Conclusions: In hospitalized COVID-19, poor correlates responses, worse increased rates unfavorable outcomes. These findings underscore necessity stringent glucose management mitigate improve prognoses this vulnerable patient population.

Language: Английский

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