Targeting the Gut Microbiota for Prevention and Management of Type 2 Diabetes

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3951 - 3951

Published: Nov. 19, 2024

Type 2 diabetes (T2D) is a chronic metabolic disorder with heterogeneous etiology encompassing societal and behavioral risk factors in addition to genetic environmental susceptibility. The cardiovascular consequences of account for more than two-thirds mortality among people T2D. Not only does T2D shorten life expectancy, but it also lowers quality associated extremely high health expenditures since diabetic complications raise both direct indirect healthcare costs. An increasing body research indicates connection between gut microbial traits, as numerous alterations the intestinal microorganisms have been noted pre-diabetic individuals. These include pro-inflammatory bacterial patterns, increased permeability, endotoxemia, hyperglycemia-favoring conditions, such alteration glucagon-like peptide-1 (GLP-1) secretion. Restoring homeostasis can be very beneficial preventing co-treating improving antidiabetic therapy outcomes. This review summarizes characteristics "diabetic" microbiota metabolites produced by species that worsen or ameliorate progression, suggesting microbiota-targeted strategies restore eubiosis regulate blood glucose. Nutritional supplementation, diet, physical exercise are known play important roles T2D, here their effects on discussed, non-pharmacological approaches greatly help management highlighting importance tailoring treatments individual needs.

Language: Английский

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New C-linked diarylheptanoid dimers as potential α-glucosidase inhibitors evidenced by biological, spectral and theoretical approaches

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139496 - 139496

Published: Jan. 7, 2025

Language: Английский

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Diabetes and Sarcopenia: Intersection of Co Morbid Conditions

OBM Geriatrics, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 23

Published: Feb. 20, 2025

Sarcopenia is more common in persons with type 2 diabetes mellitus (T2DM) than without diabetes. There overlap of some pathophysiologic features sarcopenia and T2DM. In addition, the risk for associated complications T2DM including renal disease, cardiovascular disease neuropathy. Glycemic control may have benefits on sarcopenia. The specific effects glucose lowering agents suggest that metformin, insulin, thiazolidinediones GLP1 receptor agonists favorable while SGLT2 inhibitors an adverse effect. However, RA’s been outcomes increased heart failure. Thus risk/benefit ratio overall key to selection agents. Nutrition guidelines generally align recommendations Data aerobic resistance exercise patients very limited, but data a benefit exercises.

Language: Английский

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Validation of the Persian version of the summary of diabetes self-care activities scale (SDSCA) in pregnant women with gestational diabetes mellitus using a COSMIN methodology

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 18, 2025

Gestational diabetes mellitus (GDM) is a condition with significant prenatal and postnatal implications. This study aimed to validate the Summary of Diabetes Self-Care Activities (SDSCA) measure in Iranian women GDM, focusing on its psychometric properties. The Persian version SDSCA was evaluated 180 GDM. Following COSMIN guidelines, instrument translated into Persian, properties were assessed, including content validity, face construct internal consistency, test-retest reliability, measurement error, responsiveness, interpretability. Floor ceiling effects also examined. validity assessments showed strong Content Validity Index (CVI) 0.93 Ratio (CVR) 0.97. Face yielded an impact score 4.38. Exploratory factor analysis (EFA) identified three factors-diet, exercise, blood sugar testing-accounting for 57.4% variance. Confirmatory (CFA) confirmed model's excellent fit (CFI = 1.00, TLI 0.99, NFI 0.98, RFI 0.96). reliability Cronbach's alpha 0.78 McDonald's omega 0.91, intraclass correlation coefficient (ICC) 0.92 (95% CI: 0.83-0.96). Ceiling observed testing (26.7%), while floor noted exercise (6.7%) (6.1%). Minimal Important Change (MIC) 2.68 units exceeded Smallest Detectable (SDC) 1.11 units, indicating tool's ability detect clinically meaningful changes. demonstrates properties, both making it suitable tool assessing self-care behaviors Its use future research can enhance understanding self-management this population.

Language: Английский

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Advanced Glycation End Products in Disease Development and Potential Interventions

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 492 - 492

Published: April 18, 2025

Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body introduced dietary sources smoking. Recent clinical animal studies have highlighted significant role various health conditions. These accumulate nearly all mammalian tissues associated with range diseases, including diabetes its complications, cardiovascular disease, neurodegeneration. This review summarizes major diseases linked to AGE accumulation, presenting both experimental evidence. The pathologies induced by share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, direct protein cross-linking. Interventions targeting AGE-related focus on inhibiting formation using synthetic natural antioxidants, as well intake lifestyle modifications. recognized risk factors that impact accelerate aging, particularly individuals hyperglycemia. Monitoring level implementing nutritional interventions help maintain overall reduce complications.

Language: Английский

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A new perspective of blood routine test for the prediction and diagnosis of hyperglycemia

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 25, 2025

The presence of hyperglycemia induces alterations in the blood cell microenvironment. However, further investigations are warranted to comprehend regulation physiological parameter changes within hyperglycemic cohort and validate their correlation. This study aims investigate correlation between peripheral parameters, providing valuable insights for screening treatment hyperglycemia. A retrospective was conducted analyze demographic characteristics routine test (blood RT) results both normal population individuals with distribution abnormal RT compared groups group. Univariate multivariate logistic regression analyses were employed levels In addition, stored red cells (RBCs) placed high glucose concentration low environment, parameters RBCs observed after 35 days storage. included a total 413 participants, 202 representing population. Among these, there 95 males (47.03%) 107 females (52.97%). group consisted impaired tolerance (IGT) diabetes mellitus (DM). Out sample, 61 participants IGT, consisting 45 (73.77%) 16 (26.23%). Additionally, 150 DM, including (71.33%) 43 (28.67%). prevalence showed significant increase among aged over years (p < 0.05). white count (WBC), (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), (MCHC) significantly higher than those revealed that DM had highest proportion WBC, while IGT exhibited proportions RBC, HGB, HCT analysis WBC (odds ratio [OR], 1.422; 95% CI, 1.249-1.631), RBC (OR, 2.163; 1.449-3.270), HGB 1.033; 1.020-1.047), 4.549; 0.569-8.591), MCH 1.175; 1.057-1.319), MCHC 1.071; 1.047-1.098) predictor indices Multivariate 1.434; 1.193-1.742) 4.448; 0.084-237.9) vitro experiments demonstrated decreased MCV, concurrently increasing coefficient variation width (RDW-CV) present correlations gender, age, as well certain parameters. Moreover, provided support these associations. Consequently, can serve prevention, offering essential enhance preventive strategies.

Language: Английский

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The Anti-atherosclerotic Effects of Endothelin Receptor Antagonist, Bosentan, in Combination with Atorvastatin – an Experimental Study

Published: May 14, 2024

Bosentan, an endothelin-receptor antagonist (ERA), has potential anti-atherosclerotic properties. We investigated the complementary effects of bosentan and atorvastatin on progression composition atherosclerotic lesions in diabetic mice. Forty-eight male apoE-/- mice were fed high-fat diet (HFD) for 14 weeks. At week 8, diabetes was induced with streptozotocin randomized into 4 groups: 1) Control/COG: no intervention. 2) ΒΟG: 100 mg/kg/day per os. 3) ATG: 20mg/kg/day os). 4) BO+ATG: Combined administration atorvastatin. The intra-plaque contents collagen, elastin, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-a (TNF-a), matrix-metalloproteinases (MMP-2,-3,-9), TIMP-1 concentrations determined. percentage lumen stenosis significantly decreased across all treated BOG: 19.5±2.2%, 12.8±4.8%, 9.1±2.7% compared to controls (24.6±4.8%, p&amp;lt;0.001). Both increased collagen content fibrous cap thickness versus COG (p&amp;lt;0.01). All intervention groups reduced relative MCP-1, MMP-3,-9, (p&amp;lt;0.001). Importantly, showed modest but additive latter parameters (p&amp;lt;0.05). Bosentan treatment diabetic, delayed atherosclerosis enhanced plaques’ stability, showing atorvastatin, which are promising cardiovascular diseases.

Language: Английский

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The Anti-Atherosclerotic Effects of Endothelin Receptor Antagonist, Bosentan, in Combination with Atorvastatin—An Experimental Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6614 - 6614

Published: June 16, 2024

Bosentan, an endothelin receptor antagonist (ERA), has potential anti-atherosclerotic properties. We investigated the complementary effects of bosentan and atorvastatin on progression composition atherosclerotic lesions in diabetic mice. Forty-eight male ApoE-/- mice were fed high-fat diet (HFD) for 14 weeks. At week 8, diabetes was induced with streptozotocin, randomized into four groups: (1) control/COG: no intervention; (2) ΒOG: 100 mg/kg/day per os; (3) ATG: 20 (4) BO + combined administration atorvastatin. The intra-plaque contents collagen, elastin, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-a (TNF-a), matrix metalloproteinases (MMP-2, -3, -9), TIMP-1 determined. percentage lumen stenosis significantly lower across all treated BOG: 19.5 ± 2.2%, 12.8 4.8%, 9.1 2.7% compared to controls (24.6 p < 0.001). both resulted higher collagen content thicker fibrous cap versus COG (p 0.01). All intervention groups showed relative concentrations MCP-1, MMP-3, MMP-9 a TIMP-1concentration Importantly, latter parameters presented levels when 0.05). Bosentan treatment diabetic, delayed atherosclerosis enhanced plaques' stability, showing modest but additive atorvastatin, which are promising cardiovascular diseases.

Language: Английский

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Effect of Different Rates of Rambutan Peel Extract on Visfatin and Cardiac Troponin I Response in Type 2 Diabetic Rats Induced with Streptozotocin

Indian Journal of Animal Research, Journal Year: 2024, Volume and Issue: Of

Published: Nov. 12, 2024

Background: The aim of this study was to investigate the effects STZ (Streptozotocin) and Rambutan peel extract (RPE) on serum visfatin cardiac response in experimental Type 2 diabetic rats. Methods: In study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups randomly selected, each containing rats as Control (C), R100 (RPE 100 mg/kg group given with oral gavage route administration (OGRA), R200 200 OGRA), R300 300 OGRA); Diabetes (DC): 50 i.p administered group, DR100 (D+100 JPE), DR200 (D+200 DR300 (D+300 JPE). lasted a total 31 days, including adaptation (7 days), induction diabetes (3 trial period (21 days). Blood samples taken from tail vein (vena caudalis) all subjects days 0 21 study. Visfatin cTnI levels measured evaluated by ELISA method. Result: While increase mean seen mostly DC groups, most significant decrease level due addition RPE determined (p less than 0.01).As result, it concluded that had no adverse effects. It RPE, which has cardioprotective effect regulating plays role development diabetes, may be useful supporting impaired cardiovascular system function occurs diabetes.

Language: Английский

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