Metabolic syndrome

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 17, 2024

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System

Trends in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 35(4), P. 258 - 265

Published: Jan. 21, 2025

Language: Английский

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The nonlinear association between body roundness index and infertility in married women

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 18, 2025

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and but its implications for infertility risks diagnostic value are yet be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn the National Health Nutrition Examination Survey (NHANES). Logistic regression was utilized examine relationship between BRI infertility, incorporating univariate multivariate analyses, smooth curve fittings, subgroup analyses. Additionally, Receiver Operating Characteristic (ROC) analysis assessed predictive capability infertility. An increase in one unit correlated with 13% higher prevalence after adjusting covariates (OR = 1.13; 95% CI: 1.05, 1.21). Women exhibited greater odds compared reference group (OR: 2.20, 1.42, 3.42). Smooth fitting revealed positive, nonlinear relationship, an inflection point observed at 7.95. Subgroup analyses upheld robustness this association across varied demographic segments. ROC curves indicated significant potential younger women, whereas relevance diminished those over 35, akin other obesity markers. first rigorously affirm strong link increased among 20-45. To optimize fertility, maintaining healthy weight waist circumference recommended. integration into clinical practice could assist early intervention risk However, further research required identify effective markers 36-45.

Language: Английский

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Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1969 - 1991

Published: Feb. 1, 2025

Objective: This study aimed to investigate the potential mechanisms and biomarkers between Obesity (OB) carotid atherosclerosis (CAS). Methods: The GSE12828, GSE125771, GSE43292, GSE100927 datasets were combined normalized obtain CAS-related differentially expressed genes (DEGs), OB-related DEGs obtained from GSE151839 dataset GeneCards database. Unsupervised cluster analysis was conducted on CAS samples based of OB. Subsequently, immune infiltration gene set enrichment (GESA) performed. 61 machine learning models developed screen for Hub genes. Single-gene GESA focused calcium signaling pathway-related (CaRGs). Finally, high-fat diet-fed C57BL/6J ApoE −/− mice used in vivo validation. Results: MMP9, PLA2G7, SPP1 as regulators microenvironment OB patients with CAS, stratified into subtypes differences metabolic pathways classification. Enrichment indicated abnormalities inflammatory responses, signaling, lipid response obese patients. RF+GBM model identified CD52, CLEC5A, 15 CaRGs up-regulated, 12 down-regulated PLCB2, PRKCB, PLCG2 key pathway associated cell infiltration. In experiments showed that SPP1, FYB, PLCB2 mRNA levels up-regulated adipose, aortic tissues serum AS mice, CLEC5A aorta serum, PRKCB adipose serum. Conclusion: FYB may serve diagnostic populations. are CAS. These findings offer new insights clinical management therapeutic strategies individuals. Keywords: atherosclerosis, obesity, bioinformatics, unsupervised clustering analysis, model,

Language: Английский

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Identification of common ferroptosis-related genes in metabolic dysfunction-associated steatotic liver disease and atherosclerosis using the support vector machine-recursive feature elimination algorithm

Minerva Biotechnology and Biomolecular Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 1, 2025

Language: Английский

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Implementation of a WeChat mini-program-driven lifestyle intervention among overweight or obese individuals with metabolic dysfunction-associated fatty liver disease (Preprint)

Published: April 18, 2025

Weight loss is the standard recommendation for patients with metabolic dysfunction-associated fatty liver disease (MAFLD), but its successful implementation difficult in practice. Digital lifestyle interventions may provide an efficient and scalable solution to enhance patient self-management. This study aimed assess effects of a WeChat mini-program-delivered intervention on weight hepatic steatosis among overweight or obese individuals MAFLD Overweight adults clinically diagnosed transient elastography examination were enrolled this prospective randomized controlled trial. Patients randomly assigned receive either mini-program management (intervention group) care (control at 1:1 ratio. Body clinical parameters assessed baseline then 6 months. Among 89 included patients, 60.0% achieved ≥5% loss, 24.4% had ≥10% group, which greater than those control group (P <0.05). Importantly, receiving significantly more likely achieve attenuation parameter （CAP）reduction CAP normalization (57.8% vs. 31.8%, P In parallel, presented reductions enzymes (ALT, AST, GGT) (fasting insulin, HbA1c, TG, HDL-C) According fibrosis assessment, only FibroScan-aspartate aminotransferase (FAST) score decreased No significant difference was found stiffness measurement (LSM) values noninvasive scores (APRI, FIB-4, NFS, Agile 3+) between groups (P>0.05). coaching via demonstrates efficacy enhancing reduction, improving steatosis, ameliorating disorders, offering novel perspectives regarding practicality therapeutic value digital tools managing through behavioral interventions. Chinese Clinical Trial Registry ChiCTR2500100197; https://www.chictr.org.cn/

Language: Английский

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Qinlian Hongqu Decoction Ameliorates Nafld by Modulating Macrophage Polarization Mediated Via Pi3k/Akt/Nf-Κb Pathway

Published: Jan. 1, 2025

Language: Английский

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From Childhood Obesity to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hyperlipidemia Through Oxidative Stress During Childhood

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 287 - 287

Published: April 24, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is rapidly becoming the most prevalent form of chronic in both pediatric and adult populations. It encompasses a wide spectrum abnormalities, ranging from simple fat accumulation to severe conditions such inflammation, fibrosis, cirrhosis, cancer. Major risk factors for MASLD include obesity, insulin resistance, type 2 diabetes, hypertriglyceridemia. Methods: This narrative review employed comprehensive search recent literature identify latest studies on relationship between MAFLD health consequences treatment options prevent long-term damage other organs. Additionally, article presents perspectives diagnostic biomarkers. Results: Childhood obesity linked multitude comorbid remains primary factor obesity. abnormal have detrimental effects into adulthood. Scientific evidence unequivocally demonstrates role obesity-related conditions, dyslipidemia, hyperglycemia, development progression MASLD. Oxidative stress, stemming mitochondrial dysfunction, leading discusses interconnections oxidative Conclusions: Atherogenic endothelial cytokines collectively contribute Potential targets are focused prevention use drugs address elevated blood lipid levels.

Language: Английский

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Clinically Accessible Liver Fibrosis Association with CT Scan Coronary Artery Disease Beyond Other Validated Risk Predictors: The ICAP Experience

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1218 - 1218

Published: Feb. 13, 2025

Background/objectives: Cardiovascular risk (CVR) stratification in clinical settings remains limited. This study aims to evaluate parameters that could improve the identification of higher-than-expected coronary artery disease (CAD) CT scan coronarography. Methods: In a cross-sectional asymptomatic patients from Integrated Assessment Program (ICAP), volunteers aged 40-80 without diagnosed cardiovascular were assessed. CVR factors like obesity, lipid and glucose profiles, liver fibrosis (FIB-4 ≥ 1.3), C-reactive protein, family history CVD evaluated. Patients stratified by following ESC guidelines. "CVR excess" was defined as CAD-RADS 2 low-to-moderate-risk (LMR), 3 high-risk (HR), 4 very-high-risk (VHR) groups. Results: Among 219 (mean age 57.9 ± 1.15 years, 14% female), 43.4% classified LMR, 49.3% HR, 7.3% VHR. observed 18% 15% 19% VHR patients. LMR with prior statin use HR obesity more likely have (p < 0.01 p 0.05, respectively). FIB-4 modified effect on prediction for interactions 0.05). Models including age, sex, both showed strong discrimination groups (AUROC 0.84 (95% CI 0.73-0.95) 0.82 0.70-0.93), Conclusions: Suspected combined is associated excess, providing potential indications image CAD assessment

Language: Английский

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Utilidad de la grasa corporal y visceral determinada por bioimpedanciometría frente al índice de masa corporal y el perímetro de cintura en la identificación de valores elevados de diferentes escalas de riesgo de aterogénesis

Clínica e Investigación en Arteriosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 500772 - 500772

Published: March 1, 2025

Language: Английский

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