Published: Oct. 14, 2024

Catalysis and C–S bonds Our research interests focus on development of new methods for the synthesis use sulfur-containing compounds, such as thioesters thioethers. They constitute valuable synthetic intermediates target compounds material chemistry pharmaceutical applications. aim is to develop efficient transformations employing non-precious metals homogeneous catalysts. We have demonstrated usefulness in cross coupling reactions with arylzinc reagents generate ketones. A defined nickel complex was employed catalyst a series functionalized ketones successfully obtained. The scope later expanded more reactive organomanganese upon iron catalysis. Furthermore, we developed nickel-catalyzed challenging aryl chlorides thiols, whereby max. TOF 800 h-1 achieved. broad substrates containing various functional groups heterocyclic motifs converted. Further systematic studies couplings sterically hindered aliphatic thiols range electrophiles, including ortho-substituted triflates, were conducted. What Discovery Process Chemistry? Introduction State Art Chemistry (DPC) an emerging intersectoral space that characterized by chemical or syntheses enable elucidation structure-activity relationships (SARs) structure-property (SPRs) well rapid transition process development. Drug discovery are accelerated efforts this has led chemists academia industry alike place increasing importance these aims. In seminar, explore recent advances DPC impact it can SAR/SPR interrogation downstream drug efforts. Designing New Synthetic Concepts Imparting Molecular Complexity C-1 Sources direct transfer nucleophilic CH2X unit into existing linkage enables formal introduction moiety precisely degree functionalization. Upon fine tuning reaction conditions governing transformation, initial homologation event serve manifold triggering unusual rearrangement sequences leading architectures through unique operation. – full chemoselective - conversion ketone homologated all-carbon quaternary aldehyde (via a), telescoped imine-surrogates aziridines b) bis-trifluoromethyl-β-diketiminates c) will illustrate unprecedented concepts. Additionally, disulfides thiosulfonates furnish symmetrical d) unsymmetrical oxothio- dithio-acetals e). one-step mono-fluoromethylation carbon electrophiles extremely labile fluoromethyllithium provide novel entry fluorinated building-blocks without needing using protecting elements fluoro-containing carbanions f). Finally, strategies not relying external C1-sources be discussed.

Language: Английский