Oncogene,
Journal Year:
2016,
Volume and Issue:
36(11), P. 1461 - 1473
Published: Sept. 12, 2016
Wnt
signaling
is
one
of
the
key
cascades
regulating
development
and
stemness,
has
also
been
tightly
associated
with
cancer.
The
role
in
carcinogenesis
most
prominently
described
for
colorectal
cancer,
but
aberrant
observed
many
more
cancer
entities.
Here,
we
review
current
insights
into
novel
components
pathways
describe
their
impact
on
development.
Furthermore,
highlight
expanding
functions
both
solid
liquid
tumors.
We
findings
how
affects
maintenance
stem
cells,
metastasis
immune
control.
Finally,
provide
an
overview
strategies
to
antagonize
challenges
that
are
such
approaches.
Science,
Journal Year:
2017,
Volume and Issue:
357(6349), P. 409 - 413
Published: July 27, 2017
The
genomes
of
cancers
deficient
in
mismatch
repair
contain
exceptionally
high
numbers
somatic
mutations.
In
a
proof-of-concept
study,
we
previously
showed
that
colorectal
with
deficiency
were
sensitive
to
immune
checkpoint
blockade
antibodies
programmed
death
receptor-1
(PD-1).
We
have
now
expanded
this
study
evaluate
the
efficacy
PD-1
patients
advanced
repair-deficient
across
12
different
tumor
types.
Objective
radiographic
responses
observed
53%
patients,
and
complete
achieved
21%
patients.
Responses
durable,
median
progression-free
survival
overall
still
not
reached.
Functional
analysis
responding
patient
demonstrated
rapid
vivo
expansion
neoantigen-specific
T
cell
clones
reactive
mutant
neopeptides
found
tumor.
These
data
support
hypothesis
large
proportion
neoantigens
make
them
blockade,
regardless
cancers'
tissue
origin.
New England Journal of Medicine,
Journal Year:
2015,
Volume and Issue:
372(21), P. 2018 - 2028
Published: April 19, 2015
We
assessed
the
efficacy
and
safety
of
programmed
cell
death
1
(PD-1)
inhibition
with
pembrolizumab
in
patients
advanced
non–small-cell
lung
cancer
enrolled
a
phase
study.
also
sought
to
define
validate
an
expression
level
PD-1
ligand
(PD-L1)
that
is
associated
likelihood
clinical
benefit.
