Role of Liver Kinase 1B in Platelet Activation and Host Defense During Klebsiella pneumoniae-Induced Pneumosepsis DOI Open Access
Osoul Chouchane, Valentine Léopold, Christine C. A. van Linge

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3714 - 3714

Published: April 14, 2025

Pneumonia is the most common cause of sepsis, with Klebsiella pneumoniae frequently implicated as a causative pathogen. Platelets play crucial role in host defense during and their activation essential for effective immune responses, which at least part induced through collagen receptor glycoprotein (GP)VI. require energy activation, Liver kinase B1 (LKB1) key regulator metabolism. We sought to determine LKB1 platelet function response K. pneumoniae-induced pneumosepsis. Platelet-specific-Lkb1-deficient mice were generated compared control littermates. Platelet counts unaffected by Lkb1 deficiency naïve mice. However, Lkb1-deficient platelets exhibited significant hyperreactivity GPVI stimulation, an effect not observed after stimulation thrombin protease-activated 4. During infection, both became equally hyporesponsive without differences between genotypes. Platelet-specific did alter bacterial outgrowth or dissemination, inflammatory lung pathology. These findings suggest that while plays regulating it does significantly impact pneumonia-induced sepsis.

Language: Английский

Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article DOI Creative Commons
Syed Faizan Mehdi,

M. Qureshi,

Salman Shahid

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 21, 2025

Abstract Severe sepsis is cognate with life threatening multi-organ dysfunction. There a disturbance in endocrine functions alterations several hormonal pathways. It has frequently been linked dysfunction the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia evident throughout acute phase, along changes pituitary thyroid (HPT) axis, growth hormone-IGF-1 insulin-glucose leptin, catecholamines, renin angiotensin aldosterone ghrelin, glucagon, gonadal (HGA) and fibroblast factor-21. These metabolic constitute overall response to infection sepsis. Further research essential look into that occur during sepsis, not only understand their potential relevance therapy but also because they may serve as prognostic indicators.

Language: Английский

Citations

2
The Development and Validation of a Nomogram for Predicting Sepsis Risk in Diabetic Patients with Urinary Tract Infection DOI Creative Commons

Hua-Qiao Tan,

Xiangjie Duan, Wan Qu

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 225 - 225

Published: Jan. 27, 2025

Background and Objectives: Urinary tract infection (UTI) is a common comorbidity in diabetic patients, making up one of the causes sepsis. This study aims to develop nomogram predict risk probability sepsis patients with UTI (DPUTIs). Materials Methods: retrospective observational study. Clinical data for DPUTIs were extracted from Medical Information Mart Intensive Care IV database. Eligible randomly divided into training validation cohorts 7:3 ratio. Independent prognostic factors determined using least absolute shrinkage selection operator (LASSO) regression multivariate logistic regression. A corresponding based on these was constructed occurrence DPUTIs. The discrimination assessed by multiple indicators, including area under receiver operating characteristic curve (AUC), net reclassification improvement index (NRI), integrated (IDI). In addition, calibration decision analysis (DCA) used evaluate performance nomogram. Results: total 1990 included. Nine independent identified as predictive included urine red blood cell classification (urine RBC cat), white WBC glucose, age, temperature, cells (WBCs), sequential organ failure assessment (SOFA) score, lymphocytes, hematocrit. AUC, NRI, IDI indicated robust discrimination. Hosmer–Lemeshow test showed good DCA demonstrated better clinical utility Conclusions: established this helps clinicians DPUTIs, providing evidence optimizing management related factors.

Language: Английский

Citations

0
Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study DOI Creative Commons

Manling Zou,

Di Lu, Zhiyong Luo

et al.

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 29, 2025

The role that sleep patterns play in sepsis risk remains poorly understood. objective was to evaluate the association between various behaviours and incidence of sepsis. In this prospective cohort study, we analysed data from UK Biobank (UKB). A total 409,570 participants who were free at baseline included. We used a composite score considered following five behaviours: chronotype, duration, insomnia, snoring, daytime sleepiness. Cox proportional hazards regression analysis estimate associations healthy scores incident During mean follow-up 13.54 years, 13,357 (3.26%) cases recorded. Among with age 56.47 184,124 (44.96%) male; 9942 (2.43%) reported 0 1 behaviours; 46,270 (11.30%) 2 115,272 (28.14%) 3 150,522 (36.75%) 4 87,564 (21.38%) 5 baseline. Each one-point increase associated 5% lower developing (hazard ratio (HR), 0.95; 95% confidence interval (CI), 0.93-0.97). Compared 0-1, for 5, multivariate-adjusted HR (95% CI) 0.76 (0.69-0.83). addition, found negative correlation stronger aged < 60 years than their older counterparts (p interaction 0.001). However, pattern not sepsis-related death critical care admission. Findings study suggest may reduce sepsis, particularly among younger individuals.

Language: Английский

Citations

0
Pathogenic and therapeutic roles of extracellular vesicles in sepsis DOI Creative Commons
Benshuai You, Yang Yang, Wei Jing

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

Sepsis is a systemic injury resulting in vascular dysfunction, which can lead to multiple organ even shock and death. Extracellular vesicles (EVs) released by mammalian cells bacteria have been shown play important roles intercellular communication progression of various diseases. In past decades, the functional role EVs sepsis its complications has well explored. are one paracrine components cells. By delivering bioactive materials, promote immune responses, particularly development inflammation. addition, serve as beneficial tools for therapeutic cargos. this review, we discuss dual treatment sepsis, exploring their intricate involvement both inflammation tissue repair processes. Specifically, remarkable engineered strategies based on highlighted. The engineering EVs-mediated drug delivery release offer broad prospects effective sepsis. EVs-based approaches provide novel avenue diagnosing opportunities more precise intervention.

Language: Английский

Citations

0
Identification and Prognostic Potential of Lactoylation-Related Genes in Sepsis: Implications of the Rbm25-Acly Axis DOI
Li Yu, Tao Zhang, Ling Zhou

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
One step toward the understanding of potential albumin benefits in septic patients DOI
Benjamin G. Chousterman, Marc Léone, Raphaël Favory

et al.

Journal of Critical Care, Journal Year: 2025, Volume and Issue: 87, P. 155040 - 155040

Published: March 3, 2025

Language: Английский

Citations

0
Decoy receptor 3 as a prognostic biomarker for sepsis and septic shock according to the Sepsis-3 definitions DOI Creative Commons
Long Chen, Xiao Lin,

Xing Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

Objectives The present study was conducted to reappraise the prognostic value of decoy receptor 3 (DcR3) for patients with sepsis and septic shock according latest Sepsis-3 definitions. Methods Subjects suffering from or were enrolled within 6 h admission. Sequential Organ Failure Assessment (SOFA) score plasma levels DcR3, C-reactive protein, procalcitonin, interleukin-6 measured. Group comparisons made based on survival status day 28 after onset. Predictors mortality assessed using Cox proportional hazard models, curves plotted Kaplan–Meier method. Discriminative performances single combined indicators evaluated via areas under receiver operating characteristic curves. Results Among 143 eligible cases, 77 developed shock, 28-day rates 32.2% 45.5%, respectively. Regardless population (all shock), non-survivors exhibited significantly higher DcR3 compared survivors (median 4.19 vs. 2.64 ng/mL 4.37 3.18 ng/mL, respectively; p &lt; 0.001 = 0.002, respectively). most correlated organ dysfunction presented by SOFA scores (correlation coefficient 0.347 0.308, 0.016, respectively) but did not differ among various pathogenic microbes infection. Multivariate regression identified as an independent predictor [hazard ratio (95% confidence interval): 1.570 (1.048–2.352) 1.828 (1.047–3.194), 0.029 0.034, respectively]. analysis showed that elevated concentrations associated lower (p 0.013, alone predicting outcome superior other three biomarkers (0.731 0.711, could be further improved when coupled (0.803 0.784, Conclusions is a valuable biomarker offering potential predict in clinical settings.

Language: Английский

Citations

0
The challenge of sepsis DOI Creative Commons
Jonathan Cohen

Frontiers in Science, Journal Year: 2025, Volume and Issue: 3

Published: March 18, 2025

Language: Английский

Citations

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Complexities of cardiomyopathy in septic shock DOI
Dennis L. Stevens, Amy E. Bryant

Current Opinion in Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Purpose of review This highlights the complex pathophysiology myocardial dysfunction in septic shock and emphasizes need for early repeated hemodynamic assessments to improve outcome. Recent findings Septic cardiomyopathy is a complex, dynamic process driven by multiple mechanisms such as direct depression induced host immune mediators (e.g., cytokines, nitric oxide) and/or bacterial toxins, mitochondrial metabolic dysfunction. echocardiography studies have described unique clusters (phenotypes) that correlated with clinical outcomes. Similarly, serial mean arterial pressure abnormalities patients Streptococcal Toxic Shock Syndrome (StrepTSS) yielded three distinct groups predicted mortality morbidity. Because excessive use fluids vasopressors can be detrimental, especially microvascular injury or cardiomyopathy, application cardiovascular performance criteria these different phenotypes could better inform management decisions real time Summary dynamic, multidimensional response myocardium infection involving both normal dysregulated responses which measurable changes function predict current paradigm mandates functional parameters cardiac measured repeatedly throughout disease course using guide treatment

Language: Английский

Citations

0
Analysis of bacterial spectrum and construction of a predictive model for postoperative sepsis in patients with upper urinary calculi and positive urinary cultures DOI
Yizhou Wang, Meng Gao, Minghui Liu

et al.

Expert Review of Anti-infective Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Background To analyze bacterial profiles, antibiotic resistance, and urosepsis risk factors in urine culture-positive (UC+) patients post-endoscopic lithotripsy.

Language: Английский

Citations

0