Photodynamic
therapy
with
reactive
oxygen
species
production
is
a
prospective
treatment
to
combat
cancer
stem
cells
(CSCs).
However,
the
innate
drawbacks,
including
short
lifetime
and
diffusion
distance
of
hypoxia
within
solid
tumors,
have
become
bottlenecks
for
clinical
applications
photodynamic
therapy.
Here,
we
develop
mitochondria-targeting
hemicyanine–oleic
acid
conjugate
(CyOA),
which
can
self-assemble
into
supramolecular
nanoparticles
(NPs)
without
any
exogenous
excipients.
CyOA
also
shown
targeting
mitochondrial
complex
II
protein
succinate
dehydrogenase
inhibit
oxidative
phosphorylation
reverse
tumor
hypoxia,
resulting
in
50.4-fold
higher
phototoxicity
against
breast
(BCSCs)
compared
SO
3
-CyOA
NPs
that
cannot
target
mitochondria.
In
4T1
BCSC
models,
achieve
inhibition
less
lung
metastasis
nodules
clinically
used
photosensitizer
Hiporfin.
This
study
develops
self-assembled
small
molecule
serve
as
both
inhibitor
eradication
CSCs
tumors.
Micromachines,
Journal Year:
2022,
Volume and Issue:
13(8), P. 1279 - 1279
Published: Aug. 8, 2022
The
multi-faceted
nature
of
functionalized
magnetic
nanoparticles
(fMNPs)
is
well-suited
for
cancer
therapy.
These
nanocomposites
can
also
provide
a
multimodal
platform
targeted
therapy
due
to
their
unique
guidance
characteristics.
When
induced
by
an
alternating
field
(AMF),
fMNPs
convert
the
magnetostatic
energy
heat
hyperthermia
(MHT),
as
well
controlled
drug
release.
Furthermore,
with
ability
near-infrared
(NIR)
light
energy,
have
attracted
interest
photothermal
(PTT).
Other
than
MHT
and
PTT,
place
in
combination
therapies,
such
chemo-MHT,
chemo-PTT,
chemo-PTT–photodynamic
therapy,
among
others,
versatile
properties.
Thus,
this
review
presents
multifunctional
based
on
AMF
or
NIR
light.
We
will
first
discuss
different
chemo-MHT.
Secondly,
we
irradiated
lasers
PTT
chemo-PTT.
Finally,
used
dual-mode
+
NIR-laser-induced
magneto-photo-hyperthermia
(MPHT)
be
discussed.
Photochemistry and Photobiology,
Journal Year:
2022,
Volume and Issue:
99(2), P. 356 - 419
Published: Sept. 26, 2022
Abstract
This
review
follows
the
research,
development
and
clinical
applications
of
photosensitizer
5,10,15,20‐tetra(
m
‐hydroxyphenyl)chlorin
(
THPC,
temoporfin)
in
photodynamic
(cancer)
therapy
(PDT)
other
medical
applications.
Temoporfin
is
active
substance
medicinal
product
Foscan®
authorized
EU
for
palliative
treatment
head
neck
cancer.
Chemistry,
biochemistry
pharmacology,
as
well
temoporfin
are
addressed,
including
extensive
work
that
has
been
done
on
formulation
liposomal
formulations.
The
literature
covered
from
2009
to
early
2022,
thereby
connecting
it
previous
this
published
journal
[Senge,
M.
O.
J.
C.
Brandt
(2011)
Photochem.
Photobiol.
87,
1240–1296]
which
followed
its
way
initial
approval
application.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(36), P. 8586 - 8604
Published: Jan. 1, 2023
Immunotherapy
is
a
new
type
of
tumor
treatment.
In
this
review,
the
main
focus
on
an
overview
research
progress
immunotherapy
in
cancer
treatment
and
combined
application
with
other
therapeutic
approaches.
Photodynamic
therapy
with
reactive
oxygen
species
production
is
a
prospective
treatment
to
combat
cancer
stem
cells
(CSCs).
However,
the
innate
drawbacks,
including
short
lifetime
and
diffusion
distance
of
hypoxia
within
solid
tumors,
have
become
bottlenecks
for
clinical
applications
photodynamic
therapy.
Here,
we
develop
mitochondria-targeting
hemicyanine–oleic
acid
conjugate
(CyOA),
which
can
self-assemble
into
supramolecular
nanoparticles
(NPs)
without
any
exogenous
excipients.
CyOA
also
shown
targeting
mitochondrial
complex
II
protein
succinate
dehydrogenase
inhibit
oxidative
phosphorylation
reverse
tumor
hypoxia,
resulting
in
50.4-fold
higher
phototoxicity
against
breast
(BCSCs)
compared
SO
3
-CyOA
NPs
that
cannot
target
mitochondria.
In
4T1
BCSC
models,
achieve
inhibition
less
lung
metastasis
nodules
clinically
used
photosensitizer
Hiporfin.
This
study
develops
self-assembled
small
molecule
serve
as
both
inhibitor
eradication
CSCs
tumors.
