A novel micromixer based on coastal fractal for manufacturing controllable size liposome

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

The traditional lipid preparation methods are complex, time-consuming, and consume a large amount of reagents, increasing costs difficulties. Although microfluidic technology is considered promising solution, achieving controllable liposome production with simple inexpensive mixing device remains an important problem. This paper presents wall-type micro-mixer based on coastal zone fractals. Four parameters related to the geometric shape coastline fractal in microchannel used as design variables, index objective function. Single-objective optimization numerical analysis primary baffle micromixer under four Reynolds numbers conditions yields optimal structural configuration. Visualization experiments verify correctness accuracy simulation, optimized mixer produce liposomes. results show that double-sidewall cross arrangement enhances chaotic convection improves efficiency. At Re = 0.1 100, efficiency reaches 99%, 50.44% higher than reference design. By changing relative flow rates aqueous solutions, blank liposomes particle size 165.12 ± 11.6 nm polydispersity 0.35± obtained. has broad application prospects due its high

Language: Английский

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Microfluidic Technology: A New Strategy for Controllable Synthesis of Metal Nanomaterials

ChemElectroChem, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Microfluidic technology has exhibited remarkable potential and significance in the precise preparation of multifunctional nanomaterials. Thanks to its small reaction volume superior hydrodynamic control, this emerged as an essential tool for synthesizing nanomaterials with precisely tunable microstructures morphologies. This paper reviews latest advancements controllable synthesis metal nano‐electrocatalysts utilizing microfluidic technology. Firstly, it systematically elucidates fundamental principles distinctive parameter control strategies. Subsequently, delves deeply into mechanism enhancement process nanoparticles environment. Through analysis specific cases, extensive application prospects advantages system have been further elucidated. Finally, summarizes looks forward challenges future development directions that faces nano‐electrocatalysts. review aims provide valuable insights morphology design technological innovation electrocatalysts.

Language: Английский

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Numerical simulation of the influence of microchannel flow field on particle separation under changes in geometric structure

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 1, 2025

This paper systematically investigated the microfluidic chip with inertial contraction and expansion channels based on numerical simulation methods. The influence of geometric shape changes particle separation effect was focused on. We varied microchannel structural parameters such as channel length width, overall curvature microchannel. results indicated that different structures hold diverse effects recovery rate. An appropriate shrinkage–expansion ratio can improve effect. In microchannel, we found six seven are optimal structure, which capable achieving effective three types particles. vortex structure in dramatically impacts focusing width particles distance particles, may be considered internal mechanism to explain trajectory channel. Furthermore, has a great rate As degree bending leaps, will first decrease then increase. study establishes theoretical foundation for understanding interaction between diversifications chips efficiency.

Language: Английский

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Synergistic interaction of thixotropy and inertia in a C-shaped serpentine channel

International Journal of Mechanical Sciences, Journal Year: 2025, Volume and Issue: 289, P. 110068 - 110068

Published: Feb. 20, 2025

Language: Английский

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Effect of complex vortices generated by asymmetrically distributed induced charges on fluid flow and mass transfer in pressure driven micromixers

Chaos Solitons & Fractals, Journal Year: 2025, Volume and Issue: 196, P. 116373 - 116373

Published: April 4, 2025

Language: Английский

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Model-Based Investigation of a Dielectrophoretic Microfluidic Device for the Separation of Polystyrene Particles

Microgravity Science and Technology, Journal Year: 2024, Volume and Issue: 36(6)

Published: Nov. 26, 2024

Language: Английский

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Nozzle model for equivalently simulating the dynamic characteristics of human exhalation clouds

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 1, 2025

Current airway models for simulating human expiratory cloud diffusion face challenges due to numerous difficult-to-define entry boundaries and unverified simplifications, potentially leading inaccurate simulations of dynamic characteristics exhaled clouds. To address this challenge, a nozzle geometry boundary structure is designed with inclined channels main channel containing an internal obstacle. The primarily affect the vertical velocity cloud, while obstacle in influences vortices, thereby impacting exhalation cloud. effects angle channels, length, width on four key parameters characterizing dispersion: penetration distance, area, upper angle, lower are assessed study. Bayesian optimization was employed based results involving various structures. Optimization indicated that 63.3 degrees, dimensions 2.8 mm width, 5.2 length yielded minimal deviation. Numerical using these optimized closely matched captured by Schlieren, average deviation within 8%, effectively model offers reliable conditions numerical exhalation, minimizing discrepancies between experimental results.

Language: Английский

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Enhancement in electroosmotic mixing in obstruction-laden microchannels

Microfluidics and Nanofluidics, Journal Year: 2025, Volume and Issue: 29(3)

Published: Feb. 5, 2025

Language: Английский

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Decoding interactions between biofilms and DNA nanoparticles

Biofilm, Journal Year: 2025, Volume and Issue: 9, P. 100260 - 100260

Published: Feb. 6, 2025

Biofilms present a great challenge in antimicrobial therapy due to their inherent tolerance conventional antibiotics, promoting the need for advanced drug delivery strategies that improve therapy. While various nanoparticles (NPs) have been reported this purpose, DNA-based NPs remain largely unexploited resource against biofilm-associated infections. To fill gap and lay groundwork potential therapeutic exploitation, we investigated diffusion, penetration, retention behaviors of three nanocarriers -plain or modified-within P. aeruginosa biofilms. Watson-Crick base pairing hydrophobic interactions mediated formation plain whilst electrostatic interaction enabled optimization coated via microfluidic mixing. We assessed with biofilm structures Single Plane Illumination Microscopy - Fluorescence Correlation Spectroscopy (SPIM-FCS) Confocal Laser Scanning (CLSM). demonstrate impact parameters on physicochemical properties modified DNA subsequent distinct biofilm. Our results show single stranded micelles (ssDNA micelle) tetrahedral nanostructures (TDN) had similar diffusion penetration profiles, whereas chitosan-coated TDN (TDN-Chit) showed reduced increased retention. This is attributable relatively larger size positive surface charge TDN-Chit NPs. The study shows first foremost can be used as building block antibiofilm therapeutics. Moreover, overall behavioral findings are pivotal strategic selection agents encapsulated within these structures, possibly affecting treatment efficacy. research not only highlights underexplored but also advocates further studies using different refine nanocarrier systems targeted treatments biofilm-related

Language: Английский

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Valveless micro piezoelectric pump and mixer with wide-angle diffusers: Effect analysis of diffuser angle though piezoelectric-fluid coupled simulation

Microsystem Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

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