Revista Científica,
Journal Year:
2023,
Volume and Issue:
47(2), P. 1 - 12
Published: May 15, 2023
Este
trabajo
describe
una
metodología
sintética
desarrollada
para
la
obtención
de
pirazolo[3,4-b]piridinas
policíclicas
fusionadas.
La
síntesis
se
llevó
a
cabo
en
dos
etapas,
iniciando
con
naftonas
α,β-insaturadas
y
su
posterior
ciclocondensación
5-amino-1-fenil-3-metil-1H-pirazol.
Las
ventajas
este
enfoque
incluyen
simplicidad,
eficiencia
atómica,
selectividad
buen
rendimiento
un
mínimo
impacto
ambiental.
ruta
está
orientada
hacia
N-heterociclos
puntos
específicos
diversificación
estructural
que
sean
interés
exploración
sus
propiedades
biológicas.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(28)
Published: July 22, 2024
Abstract
In
the
present
era,
concept
of
green
in
organic
synthesis
has
a
unique
and
irreplaceable
place.
Specifically,
nanoparticle
gained
much
more
attention
due
to
its
various
properties
related
chemistry.
this
context,
magnetic
been
widely
used
over
last
one
decade.
Among
compounds,
pyrazole
scaffolds
are
recognized
as
privileged
structure
it
represents
promising
area
for
identification
lead
structures
towards
discovery
new
synthetic
drug
molecules
other
valuable
candidates.
Several
commercial
drugs
such
Sildenafil,
Rimonabant,
Celecoxib
many
compounds
biological
testing
preclinical
evaluation,
illustrate
wide
therapeutic
spectrum
class
scaffolds.
Accordingly,
nanoparticles
have
an
place
derivatives
is
easy
methodology
chemists.
The
manuscript
assimilation
literature
pertaining
aspects
highly
diversified
pyrazole.
Journal of Heterocyclic Chemistry,
Journal Year:
2018,
Volume and Issue:
56(1), P. 268 - 274
Published: Nov. 26, 2018
In
this
research,
in
order
to
synthesize
a
series
of
ethyl
2‐amino‐4‐benzoyl‐5‐oxo‐5,6‐dihydro‐4
H
‐pyrano[3,2‐
c
]quinoline‐3‐carboxylates,
green
and
an
efficient
method
is
proposed
through
one‐pot
three‐component
reaction
substituted
arylglyoxals,
cyanoacetate,
4‐hydroxyquinolin‐2(1
)‐one
the
presence
terapropylammonium
bromide
as
catalyst
good
yields.
All
synthesized
new
substances
were
characterized
by
FTIR,
1
H‐NMR,
13
C‐NMR
spectral
data
elemental
analysis.
Green Processing and Synthesis,
Journal Year:
2019,
Volume and Issue:
8(1), P. 533 - 541
Published: Jan. 28, 2019
Abstract
Pyrazolopyridine
and
pyrazoloquinoline
derivatives
were
obtained
by
a
one-pot,
three-component
reaction
of
arylglyoxals,
3-methyl-1-aryl-1
H
-pyrazol-5-amines
cyclic
1,3-dicarbonyl
compounds
in
the
presence
tetrapropylammonium
bromide
at
80°C
water
through
Knoevenagel
Micheal
reactions,
followed
intramolecular
condensation,
unexpected
dearoylation
oxidation.
Mild
conditions,
high
yields,
simplicity
work
up
procedure,
starting
materials
availability
clean
product
formation
are
some
main
advantages
this
synthetic
strategy.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(23), P. 5958 - 5964
Published: Jan. 1, 2023
A
novel
[3
+
1
1]
cyclization
reaction
for
the
synthesis
of
compounds
based
on
a
5-cyano-1
H
-pyrazolo[3,4-
b
]pyridine
skeleton
from
aryl
methyl
ketones,
malononitrile
and
5-aminopyrazoles
has
been
established.
Journal of Heterocyclic Chemistry,
Journal Year:
2019,
Volume and Issue:
56(6), P. 1857 - 1865
Published: May 10, 2019
The
one‐pot,
three‐component,
synthesis
of
a
new
series
4‐hydroxy‐3‐(2‐arylimidazo[1,2‐
]pyridin‐3‐yl)quinolin‐2(1
H
)‐ones
in
the
presence
DABCO
as
catalyst
has
been
achieved
using
aryl
glyoxal
monohydrates,
quinoline‐2,4(1
,3
)‐dione,
and
2‐aminopyridine
2
O/EtOH
under
reflux
conditions.
cheapness
organocatalyst,
simple
workup,
operational
simplicity,
regioselectivity,
high
yields
are
some
advantages
this
protocol.
Journal of Heterocyclic Chemistry,
Journal Year:
2019,
Volume and Issue:
56(10), P. 2912 - 2921
Published: Sept. 9, 2019
A
new
series
of
benzo[
g
]thiazolo[2,3‐
b
]quinazolin‐4‐ium
and
]benzo[4,5]thiazolo[2,3‐
]quinazolin‐14‐ium
hydroxide
derivatives
have
been
synthesized
by
the
one‐pot,
three‐component
reaction
aryl
glyoxal
monohydrates,
2‐hydroxy‐1,4‐naphthoquinone,
2‐aminothiazole
or
2‐aminobenzothiazole
in
presence
triethylamine
p
‐toluenesulfonic
acid
as
organocatalysts
H
2
O/acetone
(2:1)
at
room
temperature.
This
method
offers
mild
conditions,
excellent
yields,
easy
workup,
readily
accessible
starting
materials
catalysts.
ARKIVOC,
Journal Year:
2018,
Volume and Issue:
2019(5), P. 1 - 9
Published: Oct. 16, 2018
Eight
polyfunctionalized
pyrimidonaphthyridine
derivatives
has
been
synthesized,
in
79-92%
yields,
via
the
one-pot,
three-component
reaction
of
aryl
glyoxal
monohydrates,
6-aminouracil
and
4-hydroxyquinolin-2(1H)one
H
2
O/EtOH
presence
AgNPs
under
mild
conditions.In
this
work
colloidal
acts
as
an
efficient,
economical,
green
nanocatalyst,
leading
to
a
simple
method
preparation.
Heterocyclic Communications,
Journal Year:
2018,
Volume and Issue:
24(6), P. 297 - 302
Published: Nov. 17, 2018
Abstract
An
improved
synthesis
of
2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4
H
)-ylidene)-6-aryl-5,6-dihydroimidazo[2,1-
b
][1,3,4]thiadiazol-7-ium
hydroxide
derivatives
4a–k
via
the
reaction
aryl
glyoxal
monohydrates
1a–k
,
quinoline-2,4-diol
2
and
2-amino-[1,3,4]thiadiazole
(3)
in
presence
Et
3
N/sulfamic
acid
O
is
described.
This
green
protocol
characterized
by
use
readily
available
catalyst
reactants,
short
times,
operational
simplicity
high
yields
products.
The
structures
all
compounds
were
1
NMR,
13
C
NMR
Fourier-transform
infrared
(FT-IR)
spectral
data
microanalyses.
