Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

Immunity, Journal Year: 2014, Volume and Issue: 40(6), P. 833 - 842

Published: June 1, 2014

Language: Английский

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Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Journal of Gastroenterology, Journal Year: 2016, Volume and Issue: 52(1), P. 1 - 8

Published: July 23, 2016

Language: Английский

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

Immunity, Journal Year: 2019, Volume and Issue: 50(2), P. 432 - 445.e7

Published: Jan. 25, 2019

Language: Английский

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The gut microbiome: Relationships with disease and opportunities for therapy

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 20 - 40

Published: Oct. 15, 2018

Over the past decade, our view of human-associated microbes has expanded beyond that a few species toward an appreciation diverse and niche-specialized microbial communities develop in human host with chronological age. The largest reservoir exists distal gastrointestinal tract, both lumen, where facilitate primary secondary metabolism, on mucosal surfaces, they interact immune cell populations. While local microbial-driven immunomodulation gut is well described, more recent studies have demonstrated role for microbiome influencing remote organs hematopoietic function. Unsurprisingly, therefore, perturbation to composition function microbiota been associated chronic diseases ranging from inflammatory metabolic conditions neurological, cardiovascular, respiratory illnesses. Considerable effort currently focused understanding natural history development humans context health outcomes, parallel improving knowledge microbiome-host molecular interactions. These efforts ultimately aim effective approaches rehabilitate perturbed ecosystems as means restore or prevent disease. This review details modulating focus discusses strategies manipulating management prevention conditions.

Language: Английский

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Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(1), P. 110 - 130

Published: June 15, 2017

Language: Английский

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