Circulating sex hormone levels and colorectal cancer risk in Japanese postmenopausal women: The JPHC nested case–control study DOI Open Access
Nagisa Mori, Norie Sawada, Motoki Iwasaki

et al.

International Journal of Cancer, Journal Year: 2019, Volume and Issue: 145(5), P. 1238 - 1244

Published: May 27, 2019

Previous epidemiological studies evaluated endogenous sex hormone levels and colorectal cancer (CRC) risk have yielded inconsistent results. Also, it is unknown if consumption of dietary isoflavones may influence the hormones CRC relationships. We conducted a nested case-control study within JPHC Study Cohort II wherein 11,644 women provided blood samples at 5-year follow-up survey. selected two matched controls for each case from cohort (185 cases 361 controls). Multivariable conditional logistic regression was used to estimate odds ratios (ORs), 95% confidence intervals (CIs) association between circulating risk. Comparing extreme tertiles, testosterone were positively associated with (OR = 2.10, CI 1.11-3.99, p trend 0.03). Levels estradiol, SHBG, progesterone not In subgroup analysis by isoflavone intake, SHBG among those low total intake (p 0.03), statistically nonsignificant inverse high 0.22; interaction 0.002). Endogenous postmenopausal women. The development be altered level intake.

Language: Английский

Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism DOI Open Access
Camila M. Lopes‐Ramos, Marieke L. Kuijjer, Shuji Ogino

et al.

Cancer Research, Journal Year: 2018, Volume and Issue: 78(19), P. 5538 - 5547

Published: Oct. 1, 2018

Understanding sex differences in colon cancer is essential to advance disease prevention, diagnosis, and treatment. Males have a higher risk of developing lower survival rate than women. However, the molecular features that drive these are poorly understood. In this study, we use both transcript-based gene regulatory network methods analyze RNA-seq data from The Cancer Genome Atlas for 445 patients with cancer. We compared expression between tumors men women observed significant chromosome genes only. then inferred patient-specific networks found males females, drug xenobiotics metabolism via cytochrome P450 pathways more strongly targeted females. This finding was validated dataset 1,193 five independent studies. While targeting, pathway did not change overall treated adjuvant chemotherapy, females greater targeting showed an increase 10-year probability, 89% [95% confidence interval (CI), 78-100] 61% (95% CI, 45-82) respectively (P = 0.034). Our analysis uncovers patterns transcriptional regulation differentiate male female identifies processes involving associated who receive chemotherapy. approach can be used investigate other cancers complex diseases.Significance: A network-based reveals sex-specific by regulators outcome understand how influences progression response therapies cancers. Res; 78(19); 5538-47. ©2018 AACR.

Language: Английский

Citations

104
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions DOI Creative Commons

Bhavisha Doshi,

Sarah R. Athans, Anna Woloszynska‐Read

et al.

Oncogenesis, Journal Year: 2023, Volume and Issue: 12(1)

Published: Sept. 4, 2023

Abstract Sex and gender disparities in bladder cancer have long been a subject of interest to the research community, wherein men 4 times higher incidence rate than women, female patients often present with higher-grade disease experience worse outcomes. Despite known differences clinical outcomes between male patients, management remains same. In this review, we critically analyze studies that report on biological women evaluate how these contribute sex cancer. Distinct characteristics immune systems, circulating hormone levels receptor expression, different genetic epigenetic alterations are major factors all likely disparate rates for patients. Future preclinical area should employ experimental approaches account consider cancer, thereby facilitating development precision medicine effective treatment

Language: Английский

Citations

26
Androgen-mediated regulation of skeletal muscle protein balance DOI
Michael L. Rossetti, Jennifer L. Steiner, Bradley S. Gordon

et al.

Molecular and Cellular Endocrinology, Journal Year: 2017, Volume and Issue: 447, P. 35 - 44

Published: Feb. 23, 2017

Language: Английский

Citations

84
Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases DOI
Arnaud Blomme, Gaëtan Van Simaeys, Gilles Doumont

et al.

Oncogene, Journal Year: 2017, Volume and Issue: 37(9), P. 1237 - 1250

Published: Dec. 12, 2017

Language: Английский

Citations

71
Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development DOI Open Access

Hee Jin Son,

Sung Hwa Sohn,

Nayoung Kim

et al.

Cancer Research and Treatment, Journal Year: 2018, Volume and Issue: 51(2), P. 632 - 648

Published: Aug. 1, 2018

This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model.AOM/DSS-treated male female mice were sacrificed at weeks 2, 10, 16, to assess estrogen effects on colitis carcinogenesis. Macroscopic histologic severity of Western blot quantitative real-time polymerase chain reaction evaluated, measure inflammatory mediators cytokines.Compared with AOM/DSS-treated (M-AOM/DSS group), administration (M-AOM/DSS+estr group) displayed week 2 significantly decreased colitis. At 10 (F-AOM/DSS the M-AOM/DSS+estr group showed lower tumor multiplicity compared M-AOM/DSS group. F-AOM/DSS had a level nuclear factor-κB (NF-κB) expression higher factor erythroid 2-related (Nrf2) expression, levels NF-κB its related group, while Nrf2 Nrf2-related anti-oxidant enzymes increased. In addition, increased Nod-like receptor protein 3 (NLRP3) inflammasome expressions mice. contrast, its-related NLRP3 highly expressed who developed cancer.The data suggest initiation CRC by regulating pathways. Moreover, these imply dual role inflammasome, including promotion progression upon initiation.

Language: Английский

Citations

65
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis DOI

Clemens Neufert,

Christina Heichler, Thomas Brabletz

et al.

Nature Protocols, Journal Year: 2020, Volume and Issue: 16(1), P. 61 - 85

Published: Dec. 14, 2020

Language: Английский

Citations

57
The Sex Bias of Cancer DOI
Ana R. Costa,

Mariana Lança de Oliveira,

Inés Seoane Cruz

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2020, Volume and Issue: 31(10), P. 785 - 799

Published: Sept. 6, 2020

Language: Английский

Citations

54
The Interplay between Androgen and Gut Microbiota: Is There a Microbiota-Gut-Testis Axis DOI
Xiangping Li, Wei Cheng, Haitao Shang

et al.

Reproductive Sciences, Journal Year: 2021, Volume and Issue: 29(6), P. 1674 - 1684

Published: May 26, 2021

Language: Английский

Citations

51
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats DOI Creative Commons
Ruijing Liu, Dongbao Cai, Xusheng Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 239, P. 113623 - 113623

Published: May 11, 2022

Bisphenol A (BPA) is an environmental endocrine disruptor. Recent studies have shown association between decreased spermatogenesis and gut microbiota alteration. However, the potential associations mechanisms of BPA exposure on spermatogenesis, hormone production, remain unknown. This study aims to investigate BPA-induced male reproductive toxicity link with dysbiosis. Male Sprague Dawley rats were exposed at different doses by oral gavage for thirty consecutive days. The extent testicular damage was evaluated basic parameters body weight hematoxylin-eosin (H&E) staining. Next, we determined mRNA levels protein apoptosis, histone-related factors, mammalian target rapamycin (mTOR) pathway in testes. Finally, 16 S rDNA sequencing used analyze composition after exposure. damaged histology, significantly sperm count, increased abnormalities. In addition, caused oxidative stress cell apoptosis histone (H2A, H3) increased, while ubiquitin H2A (ub-H2A) H2B (ub-H2B) markedly reduced. Furthermore, activated PI3K AKT expression, but expressions mTOR 4EBP1 testes inhibited significantly. Additionally, relative abundance class Gammaproteobacteria, order Betaproteobacteriales higher when treated a high dose compared control group, which negatively correlated testosterone level. highlights relationship disorder provides new insights into prevention treatment damage.

Language: Английский

Citations

36
Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case–Control Study and Meta-Analysis DOI Creative Commons
Justin Harbs, Sabina Rinaldi,

Audrey Gicquiau

et al.

Cancer Epidemiology Biomarkers & Prevention, Journal Year: 2022, Volume and Issue: 31(4), P. 793 - 803

Published: Jan. 27, 2022

Abstract Background: Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking. Methods: We conducted a comprehensive nested case–control study circulating concentrations hormones, hormone precursors, and binding globulin (SHBG) relation subsequent colon risk European men. Concentrations were measured using liquid LC/MS-MS prospectively collected plasma samples from 690 cases matched controls the Prospective Investigation into Cancer Nutrition (EPIC) Northern Sweden Health Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used estimate odds ratios (OR) 95% confidence intervals (CI). In addition, we meta-analysis previous studies on Results: Circulating levels testosterone (OR, 0.68; CI, 0.51–0.89) SHBG 0.77; 0.62–0.96) inversely associated risk. For free testosterone, there nonsignificant inverse association 0.83; 0.58–1.18). dose–response endogenous levels, associations colorectal/colon found for [relative risks (RR) per 100 ng/dL = 0.98; 0.96–1.00; I2 22%] (RR 1 0.95–1.00; 0%). Conclusions: Our results provide suggestive between SHBG, male development. Impact: Additional support involvement cancer.

Language: Английский

Citations

31