The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

Cell Metabolism, Journal Year: 2016, Volume and Issue: 23(4), P. 610 - 621

Published: April 1, 2016

Language: Английский

---

Clocking in to immunity

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(7), P. 423 - 437

Published: April 16, 2018

Language: Английский

---

The how’s and what’s of vaccine reactogenicity

npj Vaccines, Journal Year: 2019, Volume and Issue: 4(1)

Published: Sept. 24, 2019

Abstract Reactogenicity represents the physical manifestation of inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at injection site, as well systemic symptoms, such fever, myalgia, headache. The experience symptoms following vaccination lead needle fear, long-term negative attitudes non-compliant behaviours, which undermine public health impact vaccination. This review presents current knowledge on potential causes reactogenicity, how host characteristics, vaccine administration composition factors influence development perception reactogenicity. intent is provide an overview reactogenicity after help community, including healthcare professionals, in maintaining confidence vaccines by promoting setting expectations for vaccinees about what might occur reducing anxiety managing setting.

Language: Английский

---

Genomics of circadian rhythms in health and disease

Genome Medicine, Journal Year: 2019, Volume and Issue: 11(1)

Published: Dec. 1, 2019

Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts over myriad aspects of mammalian physiology, including the regulation sleep, metabolism, immune system. Here, we review advances in understanding genetic sleep through system, as well impact dysregulated gene expression on metabolic function. We also recent studies have begun to unravel clock’s role controlling cardiovascular nervous systems, gut microbiota, cancer, aging. Such these systems relies, part, transcriptional regulation, with evidence for genome-wide chromosome organization. These novel insights into genomic human physiology provide opportunities discovery improved treatment strategies new biological underpinnings disease.

Language: Английский

---

The dormant blood microbiome in chronic, inflammatory diseases

FEMS Microbiology Reviews, Journal Year: 2015, Volume and Issue: 39(4), P. 567 - 591

Published: May 3, 2015

Blood in healthy organisms is seen as a 'sterile' environment: it lacks proliferating microbes. Dormant or not-immediately-culturable forms are not absent, however, intracellular dormancy well established. We highlight here that great many pathogens can survive blood and inside erythrocytes. 'Non-culturability', reflected by discrepancies between plate counts total counts, commonplace environmental microbiology. It overcome improved culturing methods, we asked how common this would be blood. A number of recent, sequence-based ultramicroscopic studies have uncovered an authentic microbiome non-communicable diseases. The chief origin these microbes the gut (especially when shifts composition to pathogenic state, known 'dysbiosis'). Another source translocated from oral cavity. 'Dysbiosis' also used describe translocation cells into other tissues. To avoid ambiguity, use term 'atopobiosis' for appear places than their normal location. Atopobiosis may contribute dynamics variety inflammatory Overall, seems more chronic, non-communicable, diseases microbial component presently considered, treatable using bactericidal antibiotics vaccines.

Language: Английский

---