Toward a better understanding of folate metabolism in health and disease DOI Creative Commons
Yuxiang Zheng, Lewis C. Cantley

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(2), P. 253 - 266

Published: Dec. 26, 2018

Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, methionine regeneration. These processes in turn support critical cellular functions such as cell proliferation, respiration, epigenetic regulation. Not surprisingly, abnormal folate has been causally linked with a myriad of diseases. In this review, we provide historical perspective, delve into chemistry that often overlooked, point out various missing links underdeveloped areas future exploration.

Language: Английский

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies DOI Open Access
Guanzhong Qiu, Mingzhu Jin, Jinxiang Dai

et al.

Trends in Pharmacological Sciences, Journal Year: 2017, Volume and Issue: 38(8), P. 669 - 686

Published: June 12, 2017

Language: Английский

Citations

197
Tumor glycolysis, an essential sweet tooth of tumor cells DOI
Sumana Paul, Saikat Ghosh, Sushil Kumar

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 1216 - 1230

Published: Oct. 28, 2022

Language: Английский

Citations

193
Cancer Metabolism: Current Understanding and Therapies DOI

Jessica L. Counihan,

Elizabeth Grossman,

Daniel K. Nomura

et al.

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(14), P. 6893 - 6923

Published: June 25, 2018

Dysregulation of cancer cell metabolism contributes to abnormal growth, the biological end point cancer. We review here numerous affected oncogenes and metabolic pathways common in how they contribute pathogenesis malignancy. This also discusses various pharmacological manipulations that take advantage these abnormalities current targeted therapies have arisen from this research.

Language: Английский

Citations

189
Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism DOI Creative Commons
Michael A. Reid, Annamarie E. Allen, Shiyu Liu

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Dec. 17, 2018

Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and synthesis are required presence of abundant environmental even when uptake exceeds requirements for nucleotide synthesis. Here, we establish a mechanism how maintains metabolism. We show that inhibition induces alterations metabolism independent utilization. These changes not attributable to defects serine-derived redox maintenance, another key aspect metabolism, but result from disruption mass balance within central carbon Mechanistically, this leads simultaneous both pentose phosphate pathway tri-carboxylic acid cycle, as demonstrate based on quantitative model. findings define whereby one metabolic toxicity by simultaneously affecting activity multiple related pathways.

Language: Английский

Citations

179
Toward a better understanding of folate metabolism in health and disease DOI Creative Commons
Yuxiang Zheng, Lewis C. Cantley

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(2), P. 253 - 266

Published: Dec. 26, 2018

Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, methionine regeneration. These processes in turn support critical cellular functions such as cell proliferation, respiration, epigenetic regulation. Not surprisingly, abnormal folate has been causally linked with a myriad of diseases. In this review, we provide historical perspective, delve into chemistry that often overlooked, point out various missing links underdeveloped areas future exploration.

Language: Английский

Citations

177