Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Redox Biology, Journal Year: 2017, Volume and Issue: 11, P. 613 - 619

Published: Jan. 5, 2017

Hydrogen peroxide emerged as major redox metabolite operative in sensing, signaling and regulation. Generation, transport capture of H2O2 biological settings well their consequences can now be addressed. The present overview focuses on recent progress metabolic sources sinks the role under physiological conditions (1–10 nM), denoted oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such Nrf2/Keap1 or NF-κB. Supraphysiological (>100 nM) damage biomolecules, distress. Three questions are addressed: How assayed setting? What H2O2? is stress?

Language: Английский

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Lactate in the brain: from metabolic end-product to signalling molecule

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(4), P. 235 - 249

Published: March 8, 2018

Language: Английский

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The assembly, regulation and function of the mitochondrial respiratory chain

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 23(2), P. 141 - 161

Published: Oct. 7, 2021

Language: Английский

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New insights into the complex role of mitochondria in Parkinson’s disease

Progress in Neurobiology, Journal Year: 2018, Volume and Issue: 177, P. 73 - 93

Published: Sept. 13, 2018

New discoveries providing insights into mitochondrial bioenergetics, their dynamic interactions as well role in cellular homeostasis have dramatically advanced our understanding of the neurodegenerative process Parkinson's disease (PD). Respiratory chain impairment is a key feature sporadic PD patients and there growing evidence that links proteins encoded by PD-associated genes to disturbances function. Against backdrop latest advances development treatments target mitochondria, we aim give an overview literature published last three decades on significance mitochondria pathogenesis PD. We describe contribution genome alterations maintenance. highlight mitophagy mechanism neurodegeneration. Moreover, focus reciprocal interaction between alpha-synuclein aggregation dysfunction. discuss novel trafficking pathway involving mitochondrial-derived vesicles within context provide synopsis most recently emerging topics research with respect mitochondria. This includes relationship cell-mediated immunity, ER-mitochondria axis, sirtuin-mediated stress response micro RNAs aetiology In addition, recent studies challenged neuro-centric view pathology, moving microglia astrocytes spotlight. Greater these mechanisms may hold for targeted therapies, addressing need disease-modifying treatment, which has remained elusive date.

Language: Английский

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The Enigma of the Respiratory Chain Supercomplex

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(4), P. 765 - 776

Published: April 1, 2017

Language: Английский

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Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

Nature Structural & Molecular Biology, Journal Year: 2017, Volume and Issue: 24(10), P. 800 - 808

Published: Oct. 1, 2017

Language: Английский

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The role of mitochondrial ROS in the aging brain

FEBS Letters, Journal Year: 2017, Volume and Issue: 592(5), P. 743 - 758

Published: Nov. 6, 2017

The brain is the most complex human organ, consuming more energy than any other tissue in proportion to its size. It relies heavily on mitochondria produce and made up of mitotic postmitotic cells that need closely coordinate their metabolism maintain essential bodily functions. During aging, damaged less ATP reactive oxygen species (ROS) accumulate. current consensus ROS cause oxidative stress, damaging resulting an energetic crisis triggers neurodegenerative diseases accelerates aging. However, model organisms, increasing mitochondrial (mtROS) extends lifespan, suggesting may participate signaling protects brain. Here, we summarize mechanisms by which mtROS are produced at molecular level, how different regions amounts mtROS, levels change during Finally, critically discuss possible roles aging as molecules agents, addressing whether age-associated increases a or consequence

Language: Английский

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Astrocyte-neuron metabolic cooperation shapes brain activity

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(8), P. 1546 - 1564

Published: Aug. 1, 2021

Language: Английский

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Generation of Reactive Oxygen Species by Mitochondria

Antioxidants, Journal Year: 2021, Volume and Issue: 10(3), P. 415 - 415

Published: March 9, 2021

Reactive oxygen species (ROS) are series of chemical products originated from one or several electron reductions oxygen. ROS involved in physiology and disease can also be both cause consequence many biological scenarios. Mitochondria the main source cell and, particularly, enzymes transport chain major contributors to this phenomenon. Here, we comprehensively review modes by which produced mitochondria at a molecular level detail, discuss recent advances field involving signalling disease, involvement supercomplexes these mechanisms. Given importance mitochondrial ROS, provide schematic guide aimed help deciphering mechanisms their production variety physiological pathological settings.

Language: Английский

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Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Cells, Journal Year: 2019, Volume and Issue: 8(8), P. 793 - 793

Published: July 30, 2019

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products detrimental oxidative stress, they have upgraded since, and now ROS are also known to be essential for regulation physiological cellular functions through redox signaling. In majority cases, metabolic demands, along with other stimuli, vital formation their actions. this review, we focus on role in regulating cell functioning communication among themselves. relevance therapy concepts is addressed here.

Language: Английский

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