Identification of bioactive metabolites using activity metabolomics

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(6), P. 353 - 367

Published: Feb. 27, 2019

Language: Английский

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Glia as architects of central nervous system formation and function

Science, Journal Year: 2018, Volume and Issue: 362(6411), P. 181 - 185

Published: Oct. 11, 2018

Glia constitute roughly half of the cells central nervous system (CNS) but were long-considered to be static bystanders its formation and function. Here we provide an overview how diverse dynamic functions glial orchestrate essentially all aspects Radial glia, astrocytes, oligodendrocyte progenitor cells, oligodendrocytes, microglia each influence development, from neuronal birth, migration, axon specification, growth through circuit assembly synaptogenesis. As neural circuits mature, distinct glia fulfill key roles in synaptic communication, plasticity, homeostasis, network-level activity monitoring alteration CNS structure Continued elucidation cell biology, interactions neurons will enrich our understanding formation, health,

Language: Английский

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(9), P. 609 - 633

Published: July 24, 2020

Language: Английский

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Astrocyte Crosstalk in CNS Inflammation

Neuron, Journal Year: 2020, Volume and Issue: 108(4), P. 608 - 622

Published: Sept. 7, 2020

Language: Английский

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Brain Glucose Metabolism: Integration of Energetics with Function

Physiological Reviews, Journal Year: 2018, Volume and Issue: 99(1), P. 949 - 1045

Published: Dec. 19, 2018

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, structural components. Neuronal glucose oxidation exceeds in astrocytes, but both rates increase direct proportion to excitatory neurotransmission; signaling metabolism are closely coupled at local level. Exact details neuron-astrocyte glutamate-glutamine cycling remain be established, specific roles lactate cellular energetics these processes debated. Glycolysis preferentially upregulated during activation even though oxygen availability sufficient (aerobic glycolysis). Three major pathways, glycolysis, pentose phosphate shunt, glycogen turnover, contribute utilization excess oxygen, adrenergic regulation aerobic glycolysis draws attention astrocytic metabolism, particularly which has a high impact on oxygen-carbohydrate mismatch. Aerobic proposed predominant young children regions, re-evaluation data necessary. Shuttling glucose- glycogen-derived from astrocytes neurons activation, neurotransmission, memory consolidation controversial topics alternative mechanisms proposed. Nutritional therapy vagus nerve stimulation translational bridges clinical treatment diverse disorders.

Language: Английский

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Astrocyte function from information processing to cognition and cognitive impairment

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(2), P. 154 - 166

Published: Jan. 21, 2019

Language: Английский

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Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

Trends in Immunology, Journal Year: 2020, Volume and Issue: 41(9), P. 758 - 770

Published: Aug. 17, 2020

Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response all CNS insults, referred as astrocyte reactivity. Long regarded passive and homogeneous, reactivity is being revealed a heterogeneous functionally powerful component of mammalian innate immunity. Nevertheless, concepts about what comprises it does incomplete sometimes controversial. This review discusses goal differentiating reactive subtypes states based on composite pictures molecular expression, cell morphology, cellular interactions, proliferative state, normal functions, disease-induced dysfunctions. A working model conceptual framework presented for characterizing diversity

Language: Английский

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The Role of Astrocytes in CNS Inflammation

Trends in Immunology, Journal Year: 2020, Volume and Issue: 41(9), P. 805 - 819

Published: Aug. 13, 2020

Language: Английский

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Neuroinflammatory astrocyte subtypes in the mouse brain

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(10), P. 1475 - 1487

Published: Aug. 19, 2021

Language: Английский

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Lactate: A Metabolic Driver in the Tumour Landscape

Trends in Biochemical Sciences, Journal Year: 2018, Volume and Issue: 44(2), P. 153 - 166

Published: Nov. 22, 2018

Language: Английский

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