Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near‐Infrared Window Emission

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(14), P. 3626 - 3630

Published: Feb. 2, 2018

Abstract Fluorescent probes in the second near‐infrared window (NIR‐II) allow high‐resolution bioimaging with deep‐tissue penetration. However, existing NIR‐II materials often have poor signal‐to‐background ratios because of lack target specificity. Herein, an activatable nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H 2 S‐activated ratiometric fluorescence and light‐up emission at 900–1300 nm. By using this specific imaging S‐rich colon cancer cells, accurate identification tumors animal models were performed. It is anticipated that development will find widespread applications biological clinical systems.

Language: Английский

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Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: May 17, 2019

Fluorophores with donor-acceptor-donor groups the emission spanning second near-infrared window (NIR-II) have recently received great attention for biomedical application. Yet, mechanism underlying equilibrium between fluorescence (radiative decay) and photothermal effect (non-radiative of these fluorophores remains elusive. Here, we demonstrate that a lipophilic NIR-II fluorophore, BPBBT, possesses both twisted intramolecular charge transfer (TICT) aggregation-induced (AIE) characteristics. Human serum albumin (HSA) binds to which changes planarity fluorophore restricts its rotation. The binding results in alteration AIE TICT state tailoring efficiency. Under guidance intraoperative image, prepared HSA-bound BPBBT nanoparticles delineate primary orthotopic mouse colon tumor metastatic lesions dimensions as small 0.5 mm × 0.3 mm, offer ablation therapy optimized timing, dosing area laser irradiation.

Language: Английский

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Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence

ACS Nano, Journal Year: 2020, Volume and Issue: 14(2), P. 2509 - 2521

Published: Feb. 5, 2020

Theranostic systems combining fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) and photothermal therapy (PTT) under safe laser fluence have great potential preclinical research clinical practice, but development of such with sufficient effective NIR-II brightness excellent properties is still challenging. Here we report a theranostic system based on semiconducting polymer nanoparticles (L1057 NPs) for PTT 980 nm irradiation, low (25 mW/cm2) high (720 fluence, respectively. Taking into consideration multiple parameters including extinction coefficient, quantum yield, portion emission region, L1057 NPs much higher than most reported organic fluorophores. The brightness, together good stability biocompatibility, allows real-time visualization whole body brain vessels detection cerebral ischemic stroke tumors clarity. maximal permissible exposure limit at allow fluence. This study demonstrates that behave as an wide range biomedical applications.

Language: Английский

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Conjugated Polymer Nanoparticles for Imaging, Cell Activity Regulation, and Therapy

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 29(5)

Published: Nov. 29, 2018

Abstract Conjugated polymer nanoparticles, considered as a class of promising nanomaterials for biomedical application, are extensively employed in bioimaging, anti‐microorganism and antitumor, gene drug delivery/release the past decade. By virtue unique photoelectric properties, such strong light absorbing quality, high brightness, good photostability, tunable spectra property, favorable compatibility, conjugated nanoparticles attract increasing attention used more emerging aspects biological fields. This review summarizes recent (2014–2018) development including design, synthesis, applications. Especially, their abilities cell activity regulation, antitumor therapy discussed detail. Finally, challenges outlooks field highlighted.

Language: Английский

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Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time

Nature Chemistry, Journal Year: 2020, Volume and Issue: 12(12), P. 1123 - 1130

Published: Oct. 19, 2020

Language: Английский

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