Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

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Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

ACS Nano, Journal Year: 2020, Volume and Issue: 14(10), P. 13536 - 13547

Published: Sept. 14, 2020

Killing tumor cells with a visualized system is promising strategy in therapy to achieve minimal side effects and high efficiency. Herein, theranostic nanomedicine (AuNCs-Pt) developed based on nanocarrier gold nanoclusters (AuNCs) bifunctions of both NIR-I/NIR-II imaging glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II capability fatal high-grade serous ovarian cancer (HGSOC) model the deep abdomen, thus facilitating it be tool for monitoring platinum transportation. Meanwhile, depletes intracellular glutathione minimize detoxification, effectively maximizing chemotherapeutic efficacy platinum. used eradicate burden this study HGSOC patient-derived xenograft hepatocellular carcinoma, suggesting great potential clinical drug sensitization.

Language: Английский

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Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

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Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 26, 2021

Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently accumulate in tumors with NIR fluorescence provide preoperative diagnosis. Most of the are excised under intraoperative navigation, whereafter, some microscopic residual completely ablated by photodynamic photothermal therapies for maximally killing cells tissues. Up 90% survival rate be achieved this synergistic image-guided surgery therapies. Importantly, nanoparticles-mediated photothermal/photodynamic plus programmed death-ligand 1 antibody significantly induce elimination enhancing effect immunotherapy. This strategy basis AIEgen improves cancer mice maximized therapeutic outcomes, holds great promise clinical treatment.

Language: Английский

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Recent advances in the development of near-infrared organic photothermal agents

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 417, P. 128844 - 128844

Published: Feb. 7, 2021

Language: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

The Innovation, Journal Year: 2021, Volume and Issue: 2(1), P. 100082 - 100082

Published: Jan. 19, 2021

Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence exhibits the merits high accuracy specificity, as well real-time detection. Among NIR-II fluorophores, organic small molecular fluorophores have shown superior properties biocompatibility, variable structure, tunable emission wavelength than inorganic materials. What's more, some also display excellent cytotoxicity when illuminated NIR laser. This review summarizes progress different central cores for cancer phototheranostics past few years, focusing on structures phototheranostic performances. Furthermore, challenges prospects future development toward clinical translation are discussed.

Language: Английский

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Organic Semiconducting Macromolecular Dyes for NIR‐II Photoacoustic Imaging and Photothermal Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(37)

Published: June 26, 2021

Abstract Owing to the unique advantages of photoacoustic imaging (PAI) and photothermal therapy (PTT) conducted over near‐infrared‐II (NIR‐II) window, development high‐efficiency optical agents with NIR‐II light responsiveness is great significance. Despite diversity developed for PAI PTT, most them are based on inorganic nanomaterials small molecular dyes, whose biosafety photostability need be further assessed, respectively. Organic semiconducting macromolecular dyes (OSMDs) featuring a large backbone becoming alternative candidates PTT owing their reliable biocompatibility, durable photostability, ideal conversion capability. This paper reviews current progress OSMD‐based in window. The three main types OSMDs different skeleton architectures introduced, applications (tumor imaging, stem cell tracking, vasculature imaging) ablation) described. Viable strategies improving performance discussed. Finally, some major issues faced by raised, future directions analyzed.

Language: Английский

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