Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

Journal of Advanced Research, Journal Year: 2022, Volume and Issue: 52, P. 3 - 18

Published: Nov. 10, 2022

Microplastic pollution seriously threatens the health and safety of humans wildlife. Avian is one main species endangered by microplastics. However, damage mechanism microplastics to digestive system avian not clear. The gut-liver axis a bidirectional channel that regulates exchange information between gut liver also key target for tissue caused pollutants. This study aimed elucidate toxicity in role it. We constructed an exposure model environmental concentrations toxicological chickens reveal polystyrene (PS-MPs) 16S rRNA, transcriptomics metabolomics. PS-MPs changed death mode from apoptosis necrosis pyroptosis upregulating Caspase 8, disrupting intestinal vascular barrier, disturbing flora promoting accumulation lipopolysaccharide. Harmful metabolites were translocated through liver-gut axis, eliciting hepatic immune responses lipid metabolism disorders apoptosis. Liver injury involves multiple molecular effects mitochondrial dynamics disturbance, oxidative stress, endoplasmic reticulum cell cycle disturbance. Furthermore, metabolomics suggested caffeine melanin may be potential natural resistance substances Taken together, our data demonstrate avian, revealing critical will provide reference protecting populations.

Language: Английский

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Microplastics from agricultural plastic mulch films: A mini-review of their impacts on the animal reproductive system

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 244, P. 114030 - 114030

Published: Sept. 1, 2022

Plastic mulch films (PMFs) are widely used to improve crop quality and quantity. Although they provide a range of benefits, degrade into widespread microplastics (MPs), which can cause an unavoidable risk environmental problems. The residue PMFs is significant source MPs in soils, then spread various ecosystems be easily absorbed by organisms due their small size, subsequently transported through food chain. Notably, have been found the human placenta, stool blood, raising urgent reminder potential dangers health. This review summarizes recent studies concerning effects on reproductive system soil invertebrates, aquatic animals rodents both sexes mechanisms affect animal system. females demonstrated that decrease oocyte quantity quality, induce ovary fibrosis, pyroptosis apoptosis granulosa cells. In addition, disrupted integrity blood-testis barrier, damaged spermatogenesis compromised sperm shown most male animals. these provided evidence act reactive oxygen species-related initiating Wnt/β-Catenin NLRP3/Caspase-1 pathways females, Nrf2/HO-1/NF-κB, p38 MAPK MAPK/Nrf2 males. Taken together, reveal toxicity from PMF serve as properly dispose waste.

Language: Английский

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Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 440, P. 129698 - 129698

Published: July 28, 2022

Language: Английский

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Polystyrene nanoplastics induce profound metabolic shift in human cells as revealed by integrated proteomic and metabolomic analysis

Environment International, Journal Year: 2022, Volume and Issue: 166, P. 107349 - 107349

Published: June 15, 2022

Nanoplastics (NPLs) are widespread in our environment. However, their impacts on human health and precise toxicity mechanisms remain poorly understood. Here we studied the internalization, release, cytotoxicity of polystyrene nanoplastics (PSNPs) using renal tubular epithelial cell line HKC derived liver HL-7702. We also employed an integrated proteomic metabolomic approach to investigate potential biological effects PSNPs cells. The abundances 4770 proteins 100 metabolites were quantified, with 785 17 detected altered levels response PSNPs. Most differential enriched a variety metabolic pathways, for example, glycolysis, citrate cycle, oxidative phosphorylation, amino acid metabolism, suggesting NPLs global cellular metabolism shift energy induced by was further confirmed Seahorse analysis. Moreover, lysosomal distribution study western blotting showed that mTORC1 signaling, central regulator inhibited upon nanoplastic exposure, likely serving as link between lysosome dysfunction defects. Taken together, findings systematically mapped key molecular changes cells provide comprehensive insights risk estimation contamination.

Language: Английский

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Benzo [a] pyrene-loaded aged polystyrene microplastics promote colonic barrier injury via oxidative stress-mediated notch signalling

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131820 - 131820

Published: June 10, 2023

Language: Английский

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Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131714 - 131714

Published: May 25, 2023

Language: Английский

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The effects of microplastic pollution on aquatic organisms

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 379

Published: Jan. 1, 2024

Language: Английский

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Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108713 - 108713

Published: May 1, 2024

Nanoplastics (NPs) are increasingly pervasive in the environment, raising concerns about their potential health implications, particularly within aquatic ecosystems. This study investigated impact of polystyrene nanoparticles (PSN) on zebrafish liver metabolism using liquid chromatography hybrid quadrupole time flight mass spectrometry (LC-QTOF-MS) based non-targeted metabolomics. Zebrafish were exposed to 50 nm PSN for 28 days at low (L-PSN) and high (H-PSN) concentrations (0.1 10 mg/L, respectively) via water. The results revealed significant alterations key metabolic pathways exposure groups. metabolites showed different responses with L-PSN H-PSN. A total 2078 metabolite features identified from raw data obtained both positive negative ion modes, 190 deemed statistically H-PSN Disruptions lipid metabolism, inflammation, oxidative stress, DNA damage, amino acid synthesis identified. Notably, induced changes building blocks, membrane-associated biomarkers, immune-related metabolites, while was associated altered antioxidant injury. For first time, found depolymerized by cytochrome P450 enzymes. Utilizing an analytical approach adverse outcome pathway (AOP), impaired stress have been as potentially conserved events (KEs) exposure. These KEs further steatosis, fibrosis tissue organ level. Ultimately, this could significantly biological health. highlights PSN-induced effects emphasizing need a better understanding risks NPs contamination

Language: Английский

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Effect of emerging pollutants on the gut microbiota of freshwater animals: Focusing on microplastics and pesticides

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174809 - 174809

Published: July 15, 2024

Language: Английский

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Polystyrene nanoplastics cause reproductive toxicity in zebrafish: PPAR mediated lipid metabolism disorder

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172795 - 172795

Published: April 25, 2024

Language: Английский

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