Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Aug. 4, 2020
The
circadian
cycle
allows
organisms
to
track
external
time
of
day
and
predict/respond
changes
in
the
environment.
In
higher
order
organisms,
rhythmicity
is
a
central
feature
innate
adaptive
immunity.
We
focus
on
role
molecular
clock
specifically
monocytes
macrophages
immune
system.
These
cells
display
their
internal
functions,
such
as
metabolism
inflammatory
mediator
production
well
functions
pathogen
sensing,
phagocytosis
migration.
mediators
are
clinical
interest
many
therapeutic
targets
chronic
disease
cardiovascular
disease,
diabetes
rheumatoid
arthritis.
Moreover,
rhythm
disruption
closely
linked
with
increased
prevalence
these
conditions.
Therefore,
understanding
mechanisms
by
which
affects
monocyte/macrophage
function
will
provide
insights
into
novel
opportunities
for
diseases.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 2, 2024
NAD(P)H
Quinone
Dehydrogenase
1
(NQO1)
plays
a
pivotal
role
in
the
regulation
of
neuronal
function
and
synaptic
plasticity,
cellular
adaptation
to
oxidative
stress,
neuroinflammatory
degenerative
processes,
tumorigenesis
central
nervous
system
(CNS).
Impairment
NQO1
activity
CNS
can
result
abnormal
neurotransmitter
release
clearance,
increased
aggravated
injury/death.
Furthermore,
it
cause
disturbances
neural
circuit
neurotransmission.
The
abnormalities
enzyme
have
been
linked
pathophysiological
mechanisms
multiple
neurological
disorders,
including
Parkinson's
disease,
Alzheimer's
epilepsy,
sclerosis,
cerebrovascular
traumatic
brain
injury,
malignancy.
contributes
various
dimensions
treatment
response
tumors.
precise
through
which
contribute
these
disorders
continue
be
subject
ongoing
research.
Building
upon
existing
knowledge,
present
study
reviews
current
investigations
describing
dysregulations
disorders.
This
emphasizes
potential
as
biomarker
diagnostic
prognostic
approaches,
well
its
suitability
target
for
drug
development
strategies
Clinical & Experimental Immunology,
Journal Year:
2024,
Volume and Issue:
216(3), P. 221 - 229
Published: March 6, 2024
Microglia
are
specialized
immune
cells
unique
to
the
central
nervous
system
(CNS).
have
a
highly
plastic
morphology
that
changes
rapidly
in
response
injury
or
infection.
Qualitative
and
quantitative
measurements
of
ever-changing
microglial
considered
cornerstone
many
microglia-centric
research
studies.
The
distinctive
morphological
variations
seen
microglia
useful
marker
inflammation
severity
tissue
damage.
Although
wide
array
damage-associated
morphologies
has
been
documented,
exact
functions
these
distinct
not
fully
understood.
In
this
review,
we
discuss
how
is
synonymous
with
function,
however,
outcomes
can
be
used
make
inferences
about
function.
For
comprehensive
examination
reactive
status
cell,
both
histological
genetic
approaches
should
combined.
However,
importance
quality
immunohistochemistry-based
analyses
overlooked
as
they
succinctly
answer
questions.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Aug. 4, 2020
The
circadian
cycle
allows
organisms
to
track
external
time
of
day
and
predict/respond
changes
in
the
environment.
In
higher
order
organisms,
rhythmicity
is
a
central
feature
innate
adaptive
immunity.
We
focus
on
role
molecular
clock
specifically
monocytes
macrophages
immune
system.
These
cells
display
their
internal
functions,
such
as
metabolism
inflammatory
mediator
production
well
functions
pathogen
sensing,
phagocytosis
migration.
mediators
are
clinical
interest
many
therapeutic
targets
chronic
disease
cardiovascular
disease,
diabetes
rheumatoid
arthritis.
Moreover,
rhythm
disruption
closely
linked
with
increased
prevalence
these
conditions.
Therefore,
understanding
mechanisms
by
which
affects
monocyte/macrophage
function
will
provide
insights
into
novel
opportunities
for
diseases.
