The role of microbiota in the pathophysiology of uterine fibroids – a systematic review DOI Creative Commons

Lidia Korczynska,

Natalia Żeber‐Lubecka, Magdalena Zgliczyńska

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 26, 2023

For a long time, the uterus had been considered sterile organ, meaning that under physiological conditions would not be colonized by bacteria. Based on available data, it may concluded gut and uterine microbiome are related, role of this is greater than expected. Despite being most common pelvic neoplasms in women reproductive age, fibroids (UFs) still poorly understood tumors whose etiology has fully determined. This systematic review presents relationship between intestinal dysbiosis fibroids. A three medical databases was carried out: MEDLINE/PubMed, Scopus Cochrane. In study, 195 titles abstracts were reviewed, including only original articles clinical trials criteria. Finally, 16 studies included to analysis. recent years, researchers dealing with reproduction broad sense have focused various locations study its pathogenesis and, consequently, prevention treatment diseases genital organ. Conventional microbial detection methods suitable for identifying bacteria, which difficult culture. Next-generation sequencing (NGS) provides an easier faster more informative analysis bacterial populations. It seems microbiota potential risk factor or affect disease process. Some changes shown many types such as Firmicutes, Proteobacteria, Actinobacteria Verrucomicrobia detected fecal samples patients view few results link fibroids, further intensive humans animal models necessary, possible use different modulations

Language: Английский

Degradation of conjugated estrogen in visible light-driven intimately coupled photocatalysis and biodegradation system DOI

Xiangwei Ding,

Qingmiao Yu,

Hongqiang Ren

et al.

Bioresource Technology, Journal Year: 2024, Volume and Issue: 406, P. 131045 - 131045

Published: June 26, 2024

Language: Английский

Citations

5
Medicines as an emergent contaminant: the review of microbial biodegration potential DOI
Rosane dos Santos Grignet, Maria Gabriela Azevedo Barros,

Andressa Alves Silva Panatta

et al.

Folia Microbiologica, Journal Year: 2022, Volume and Issue: 67(2), P. 157 - 174

Published: Jan. 3, 2022

Language: Английский

Citations

22
Ring A Cleaving Beta‐Diketone Hydrolase Is a Key Enzyme of Steroid Degradation in Anaerobic Bacteria DOI Creative Commons
Christian Jacoby,

Leonard Peller,

Jana Wenzler

et al.

Environmental Microbiology, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 1, 2025

ABSTRACT Bacterial degradation of ubiquitous and persistent steroids such as steroid hormones is important for their removal from the environment. Initial studies in anaerobic bacteria suggested that ring‐cleaving hydrolases are involved oxygen‐independent sterane skeleton degradation. However, enzymes ring A cleavage common intermediate androsta‐1,4‐diene‐3,17‐dione have remained unknown. Here, we enriched a hydrolase cholesterol/nitrate grown Sterolibacterium denitrificans Escherichia coli after heterologous expression its gene. This enzyme specifically cleaves cyclic 1,3‐diketone central intermediate, androsta‐1,3,17‐trione to 1,17‐dioxo‐2,3‐ seco ‐androstan‐3‐oate (DSAO), hallmark reaction The highly conserved was identified all known many previously unknown steroid‐degrading proteobacteria. Using enzymes, enzymatically produced DSAO chemically synthesised androsta‐1‐en‐3,17‐dione precursor, allowing identification subsequent metabolites results obtained suggest involvement an additional hydrolase, aldolase, β‐oxidation‐like cascade complete form three‐ring 5,10‐ ‐1,2,3,4‐tetranorandrosta‐5,17‐dione. key may serve functional marker monitoring contaminant at anoxic environmental sites.

Language: Английский

Citations

0
Mass spectrometric profiling of primary estrogens and estrogen metabolites in human stool and plasma partially elucidates the role of the gut microbiome in estrogen recycling DOI

Vince W Li,

Tien S. Dong,

Diana Funes

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112534 - 112534

Published: April 1, 2025

Language: Английский

Citations

0
Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy DOI Creative Commons
Kristopher J. Kennedy,

Florian J. Widner,

Olga M. Sokolovskaya

et al.

mBio, Journal Year: 2022, Volume and Issue: 13(5)

Published: Aug. 22, 2022

Some bacterial mRNAs contain a region called riboswitch which controls gene expression by binding to metabolite in the cell. Typically, riboswitches sense and respond limited range of cellular metabolites, often just one type.

Language: Английский

Citations

16
Impact of microbiota on breast cancer hormone therapy DOI Creative Commons
Safae Terrisse, Laurence Zitvogel, Guido Kroemer

et al.

Cell Stress, Journal Year: 2023, Volume and Issue: 7(3), P. 12 - 19

Published: March 10, 2023

Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by properties malignant cells but also immune microbial parameters. Thus, immunosurveillance system retards development hormone-positive contributes to therapeutic efficacy estrogen receptor antagonists aromatase inhibitors. Moreover, anticancer response profoundly modulated local intestinal microbiota, which influences cell-intrinsic signaling pathways, affects composition function infiltrate present in tumor microenvironment modulates metabolism estrogens. Indeed, specific bacteria gut produce enzymes affect enterohepatic cycle metabolites, convert estrogens into androgens or generate estrogen-like molecules. The knowledge these circuitries its infancy, calling for further in-depth analyses.

Language: Английский

Citations

9
Microbial Interactions in Pollution Control Ecosystems DOI
Qidong Yin,

Zhaolu Feng,

Yuansheng Hu

et al.

Current Pollution Reports, Journal Year: 2021, Volume and Issue: 7(2), P. 104 - 114

Published: March 29, 2021

Language: Английский

Citations

19
Identification of a 17β-estradiol-degrading Microbacterium hominis SJTG1 with high adaptability and characterization of the genes for estrogen degradation DOI

Weiliang Xiong,

Wanli Peng,

Yali Fu

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 444, P. 130371 - 130371

Published: Nov. 17, 2022

Language: Английский

Citations

14
Methylations in vitamin B12 biosynthesis and catalysis DOI
Yamini Mathur, Amrita B. Hazra

Current Opinion in Structural Biology, Journal Year: 2022, Volume and Issue: 77, P. 102490 - 102490

Published: Nov. 10, 2022

Language: Английский

Citations

13
Mechanistic and phylogenetic insights into actinobacteria‐mediated oestrogen biodegradation in urban estuarine sediments DOI Creative Commons
Tsun‐Hsien Hsiao, Yi‐Lung Chen, Menghsiao Meng

et al.

Microbial Biotechnology, Journal Year: 2021, Volume and Issue: 14(3), P. 1212 - 1227

Published: March 25, 2021

Summary Steroidal oestrogens are often accumulated in urban estuarine sediments worldwide at microgram per gram levels. These aromatic steroids have been classified as endocrine disruptors and group 1 carcinogens. Microbial degradation is a naturally occurring mechanism that mineralizes the biosphere; however, corresponding genes oestrogen‐degrading actinobacteria remain unidentified. In this study, we identified gene cluster encoding several putative ( aed ; actinobacterial oestrogen degradation) actinobacterium Rhodococcus sp. strain B50. Among them, aedA aedB involved oestrogenic A‐ring cleavage were through gene‐disruption experiments. We demonstrated oestrone 4‐hydroxylase (AedA) cytochrome P450‐type monooxygenase. also detected accumulation of two extracellular metabolites, including pyridinestrone acid (PEA) 3aα‐H‐4α(3'‐propanoate)‐7aβ‐methylhexahydro‐1,5‐indanedione (HIP), oestrone‐fed B50 cultures. Since proteobacterial edcB shared < 40% sequence identity, 4‐hydroxyestrone 4,5‐dioxygenase (namely ) could serve specific biomarker to differentiate contribution proteobacteria environmental degradation. Therefore, metabolites PEA HIP used biomarkers investigate biodegradation an sediment. Interestingly, our data suggested active degraders

Language: Английский

Citations

16