Physics of Life Reviews,
Journal Year:
2024,
Volume and Issue:
48, P. 205 - 221
Published: Feb. 12, 2024
In
primary
or
idiopathic
osteoarthritis
(OA),
it
is
unclear
which
factors
trigger
the
shift
of
articular
chondrocyte
activity
from
pro-anabolic
to
pro-catabolic.
fact,
there
a
controversy
about
aetiology
OA,
either
mechanical
inflammatory.
Chondrocytes
are
mechanosensitive
cells,
that
integrate
stimuli
into
cellular
responses
in
process
known
as
mechanotransduction.
Mechanotransduction
occurs
thanks
activation
mechanosensors,
set
specialized
proteins
convert
physical
cues
intracellular
signalling
cascades.
Moderate
levels
loads
maintain
normal
tissue
function
and
have
anti-inflammatory
effects.
contrast,
over-
under-loading
might
lead
cartilage
destruction
increased
expression
pro-inflammatory
cytokines.
Simultaneously,
mechanotransduction
processes
can
regulate
be
regulated
by
pro-
soluble
mediators,
both
local
(cells
same
joint,
i.e.,
chondrocytes
themselves,
infiltrating
macrophages,
fibroblasts
osteoclasts)
systemic
(from
other
tissues,
e.g.,
adipokines).
Thus,
complex
altered
so
cartilage-preserving
adopt
different
sensitivity
signals,
mechanic
positively
transduced
healthy
may
become
deleterious
under
OA
conditions.
This
review
aims
provide
an
overview
how
biochemical
exposome
alter
important
these
cells.
Four
principal
integrins,
Ca2+
channels,
cilium
Wnt
(canonical
non-canonical)
were
targeted.
For
each
brief
summary
response
conditions
followed
concise
published
works
focus
on
further
regulation
pathways
factors.
conclusion,
this
paper
discusses
explores
biological
mediators
influence
differential
behaviour
OA.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
51, P. 145 - 158
Published: March 1, 2025
Low
back
pain
impacts
over
600
million
people
worldwide,
predominantly
due
to
intervertebral
disc
degeneration.
This
study
focuses
on
the
role
of
Piezo1,
a
crucial
mechanosensitive
ion
channel
protein,
in
pathology
and
potential
treatment
To
investigate
effects
disc-specific
Piezo1
deletion,
we
generated
Aggrecan
CreERT2
;
fl/fl
mice
examined
both
lumbar
spine
instability
(LSI)-
aging-induced
Additionally,
effect
pharmacological
inhibition
was
evaluated
using
GsMTx4,
potent
antagonist,
an
ex
vivo
model
stimulated
with
IL-1β
induce
Assessments
included
histological
examinations,
immunofluorescence,
western
blot
analyses
thoroughly
characterize
alterations
discs.
Elevated
expression
detected
nucleus
pulposus
(NP)
discs
advanced
degeneration
aged
human
patients.
Inducible
deletion
aggrecan-expressing
cells
significantly
reduced
degeneration,
decreased
extracellular
matrix
(ECM)
degradation,
lowered
apoptosis
NP
cells,
observed
those
undergoing
LSI
surgery.
Excessive
compression
loading
(CL)
upregulated
expression,
induced
ECM
disruption,
increased
whereas
GsMTx4
effectively
mitigated
these
pathological
changes.
Furthermore,
cultured
mouse
discs,
alleviated
IL-1β-induced
degenerative
damages,
restored
anabolism,
apoptosis.
The
findings
suggest
that
plays
critical
development
highlight
its
as
therapeutic
target.
Inhibiting
could
offer
novel
strategy
for
treating
or
preventing
this
disease.
research
highlights
involvement
emphasizes
targeting
delay
reverse
condition.
