Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2401 - 2421

Published: July 1, 2022

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as distinct phenomenon and named decade ago. Ferroptosis has been implicated in broad set biological contexts, from development to aging, immunity, cancer. This review describes key regulators this within framework metabolism, ROS biology, iron biology. Key concepts major unanswered questions the ferroptosis field are highlighted. The next promises yield further breakthroughs mechanisms governing additional ways harnessing for therapeutic benefit.

Language: Английский

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Targeting ferroptosis as a vulnerability in cancer

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(7), P. 381 - 396

Published: March 25, 2022

Language: Английский

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The hallmarks of cancer metabolism: Still emerging

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(3), P. 355 - 377

Published: Feb. 4, 2022

Language: Английский

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Ferroptosis at the intersection of lipid metabolism and cellular signaling

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(12), P. 2215 - 2227

Published: April 6, 2022

Language: Английский

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Ferroptosis in infection, inflammation, and immunity

The Journal of Experimental Medicine, Journal Year: 2021, Volume and Issue: 218(6)

Published: May 12, 2021

Ferroptosis is a type of regulated necrosis that triggered by combination iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers ferroptosis can be divided into two categories (biological versus chemical) activate major pathways (the extrinsic/transporter the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death implicated in growing list physiological pathophysiological processes, coupled to dysregulated immune response. This review focuses on new discoveries related how cells their spilled contents shape innate adaptive immunity health disease. Understanding immunological characteristics activity not only illuminates an intersection between but may also lead development novel treatment approaches for immunopathological diseases.

Language: Английский

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Cellular degradation systems in ferroptosis

Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(4), P. 1135 - 1148

Published: Jan. 18, 2021

Language: Английский

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Ferroptosis in cancer and cancer immunotherapy

Cancer Communications, Journal Year: 2022, Volume and Issue: 42(2), P. 88 - 116

Published: Feb. 1, 2022

Abstract The hallmark of tumorigenesis is the successful circumvention cell death regulation for achieving unlimited replication and immortality. Ferroptosis a newly identified type dependent on lipid peroxidation which differs from classical programmed in terms morphology, physiology biochemistry. broad spectrum injury tumor tolerance are main reasons radiotherapy chemotherapy failure. effective rate immunotherapy as new treatment method less than 30%. can be seen radiotherapy, chemotherapy, immunotherapy; therefore, ferroptosis activation may potential strategy to overcome drug resistance mechanism traditional cancer treatments. In this review, characteristics causes by briefly described. addition, three metabolic regulations its crosstalk with signaling pathways summarized. Collectively, these findings suggest vital role based interaction immunotherapy, thus, indicating remarkable treatment.

Language: Английский

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Mitochondrial regulation of ferroptosis

The Journal of Cell Biology, Journal Year: 2021, Volume and Issue: 220(9)

Published: July 30, 2021

Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have essential roles in energy production, cellular metabolism, and regulation. However, their role ferroptosis has been unclear somewhat controversial. In this Perspective, I summarize the diverse metabolic processes mitochondria actively drive ferroptosis, discuss recently discovered mitochondria-localized defense systems detoxify mitochondrial peroxides protect against present new evidence for regulating outline outstanding questions on fascinating topic future investigations. An in-depth understanding functions will important implications both fundamental biology disease treatment.

Language: Английский

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Ferroptosis, radiotherapy, and combination therapeutic strategies

Protein & Cell, Journal Year: 2021, Volume and Issue: 12(11), P. 836 - 857

Published: April 23, 2021

Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play important role radiotherapy-induced and tumor suppression, mediate the synergy between radiotherapy immunotherapy. In this review, we summarize known as well putative mechanisms underlying crosstalk ferroptosis, discuss interactions ferroptosis other forms induced radiotherapy, explore combination therapeutic strategies targeting This review will provide frameworks for future investigations cancer therapy.

Language: Английский

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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

Cell, Journal Year: 2023, Volume and Issue: 186(13), P. 2748 - 2764.e22

Published: June 1, 2023

Language: Английский

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