Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior DOI Creative Commons
Man Yong Han,

Deyang Zeng,

Wei Tan

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 159 - 173

Published: April 3, 2024

Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.

Language: Английский

Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression DOI Creative Commons
Yan Zhao, Yulong Chen,

Chi-Hua Guo

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(9), P. 3653 - 3673

Published: Jan. 1, 2024

: Recent evidence highlights the pivotal role of mitochondrial dysfunction in mood disorders, but mechanism involved remains unclear. We studied whether Hippo/YAP/14-3-3η signaling pathway mediates abnormalities that result onset major depressive disorder (MDD) a mouse model.

Language: Английский

Citations

7
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway DOI Open Access

Caihong Yao,

Yiwen Zhang,

Xinran Sun

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114459 - 114459

Published: May 26, 2023

In this study, we have investigated the anti-depressant effects of fruit Areca catechu L. (ACL) and elucidated its potential underlying mechanism using a rat model chronic unpredictable mild stress (CUMS). CUMS was induced in rats to establish depression animal for 28 days. According baseline sucrose preference, male were divided into 6 different groups. They treated with paroxetine hydrochloride, ACL, water once day until behavioral tests performed. The levels corticosterone (CORT), malondialdehyde (MDA), catalase (CAT), total superoxide dismutase (T-SOD) serum detected commercial kit, concentrations 5-hydroxytryptamine (5-HT) dopamine (DA) monoamine neurotransmitters brain tissues by liquid chromatography-tandem mass spectrometry. doublecortin (DCX) expression hippocampal dentate gyrus (DG) determined immunofluorescence, relative abundance brain-derived neurotrophic factor (BDNF), TrkB, PI3K, p-AKT/AKT, PSD-95, p-GSK-3β/GSK-3β assayed western blot. ACL markedly increased decreased immobility time, shortened feeding latency CUMS-induced rats. induction resulted marked changes contents (5-HT DA) hippocampus cortex CORT, MDA, CAT, T-SOD serum, whereas administration alleviated these considerable changes. promoted DCX DG protein BDNF, brains Our results indicated that may improve depression-like behaviors decreasing hyperfunction oxidative hypothalamic-pituitary-adrenal axis, stimulating neurogenesis, activating BDNF signaling pathway.

Language: Английский

Citations

16
Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions DOI Open Access
Huiqin Wang, Xueying Yang, Huaqing Lai

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115545 - 115545

Published: Sept. 20, 2023

Hypericin is widely utilized for its precise antidepressant properties, but exact mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes the central nervous system, are concerned with pathogenesis of depression. However, role hypericin gap junctional dysfunction depression has rarely been investigated. Here, we found that junctions ultra-structurally broadened chronic unpredictable stress (CUS) rat model depression, while repaired junctions. Suppression by bilateral injection carbenoxolone (CBX) prefrontal cortex rats significantly inhibited restoration hypericin. Meanwhile, failed to show benefits. Furthermore, corticosterone (CORT)-stimulated primary derived from neonatal rats, dramatically reversed phosphorylation connexin 43 (Cx43), normalizing expression Cx43 and thereby ameliorating dysfunction. Comparatively, CBX remission on intercellular communication function. function might be a novel therapeutic target treatment provide potential insights into other herbal ingredients.

Language: Английский

Citations

14
The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors DOI Creative Commons

Huina Ma,

Hehua Huang,

Chenyu Li

et al.

npj Systems Biology and Applications, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 13, 2024

Abstract Traditional Chinese medicine is one of the most commonly used complementary and alternative therapies for depression. Integrated Chinese-western have been extensively applied in numerous diseases due to their superior efficiency individual treatment. We meta-analysis, network pharmacology, bioinformatics studies identify putative role Longya Lilium combined with Fluoxetine Depression-like behaviors were mimicked mice after exposure chronic unpredictable mild stress (CUMS). The underlying potential mechanism this combination therapy was further explored based on vitro vivo experiments analyze expression COX-2, PGE2, IL-22, activation microglial cells, neuron viability apoptosis hippocampus. antidepressant effect noted compared a single COX-2 mainly expressed hippocampal CA1 areas. reduced thus alleviated depression-like behavior neuroinflammation mice. A decrease curtailed BV-2 cell activation, inflammation, by blunting PGE2/IL-22 axis. Therefore, inactivates COX-2/PGE2/IL-22 axis, consequently relieving neuroinflammatory response resultant

Language: Английский

Citations

6
Microelectrode Arrays for Detection of Neural Activity in Depressed Rats: Enhanced Theta Activity in the Basolateral Amygdala DOI Creative Commons
F.L. Kong, Zhaojie Xu, Gucheng Yang

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Depression is a common and severely debilitating neuropsychiatric disorder. Multiple studies indicate strong correlation between the occurrence of immunological inflammation presence depression. The basolateral amygdala (BLA) crucial in cognitive physiological processing control emotion. However, due to lack detection tools, neural activity BLA during depression not well understood. In this study, microelectrode array (MEA) based on shape anatomical location brain was designed manufactured. Rats were injected with lipopolysaccharide (LPS) for 7 consecutive days induce depressive behavior. We used MEA detect before modeling, after LPS administration days. results showed that treatment, spike firing neurons region rats gradually became more intense, local field potential power also increased progressively. Further analysis revealed administration, predominantly theta rhythm, obvious periodic characteristics appearing d relative band significantly increased. summary, our suggest enhanced related state rats, providing valuable guidance research into mechanisms

Language: Английский

Citations

6
Quercetin alleviates chronic unpredictable mild stress‐induced depression‐like behavior by inhibiting NMDAR1 with α2δ‐1 in rats DOI Creative Commons
Mingyan Wang, Xin Wei, Yugai Jia

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(4)

Published: April 1, 2024

Abstract Background Depression is a serious mental disorder and the most prevalent cause of disability suicide worldwide. Chronic unpredictable mild stress (CUMS) can lead to significant acceleration depression development. Quercetin (Que) flavonoid compound with wide range pharmacological effects. Recent studies have shown that quercetin improve CUMS‐induced depression‐like behavior, but mechanism its improvement still unclear. α2δ‐1 regulatory subunit voltage‐gated calcium channel, which interact N‐methyl‐D‐aspartate receptor (NMDAR) form complex. Objective In this study, we found Que could inhibit increase NMDAR expression in rat hypothalamus induced by CUMS. pain, chronic hypertension other interacts complex, subsequently affects level NMDAR. Consequently, present study aimed investigate antidepressant effect vivo vitro explore action terms interaction between Methods Rats were randomly exposed two stressors every day for 4 weeks establish CUMS model, then sucrose preference test (SPT), forced swimming (FST), tail suspension (TST), open field (OFT) performed detect behavior rats, so as evaluate whether model was successfully established on rats. Experimental techniques such serum enzyme‐linked immunosorbent assay (ELISA), immunofluorescence, Western blot, co‐immunoprecipitation, well experiments, used mechanisms exerts Results Behavioral ELISA results showed produce reduction excitability hypothalamic–pituitary–adrenal (HPA) axis rats improvements their depressive behavior. co‐immunoprecipitation experiments produced decrease NMDAR1 levels interfered binding. addition, neural regulation PC12 cells knocked out gene further verified. Cellular demonstrated led reversal up‐regulation corticosterone‐injured cells, while had no effects knockout. Conclusions has good significantly caused It inhibiting α2δ‐1, interfering NMDAR, reducing HPA axis.

Language: Английский

Citations

6
Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair DOI Creative Commons
Danlei Liu, Xuefeng Zheng,

Yuqing Hui

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 16, 2024

Abstract Chronic stress-induced anxiodepression is a common health problem, however its potential neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp electrophysiology, chemogenetic, and optogenetic approaches to clarify the response of lateral hypothalamus (LH) medial prefrontal cortex (mPFC) stress, confirmed structural connections between LH mPFC, investigated role LH–mPFC pathway in chronic symptoms. Unpredictable mild stress (UCMS) caused anxiodepression-like behaviors, including anxiety, anhedonia, despair behaviors. discovered that activity mPFC was both increased after restraint (RS), stressor UCMS. Then we found orexinergic neurons predominantly project glutamatergic excitability these were In addition, overactivated terminals induced anhedonia but not anxiety behaviors naive mice. Moreover, chemogenetically inhibited projection blocked orexin receptors alleviated UCMS-treated Our study identified new neurocircuit from revealed regulating stress.

Language: Английский

Citations

5
Astrocyte atrophy induced by L-PGDS/PGD2/Src signaling dysfunction in the central amygdala mediates postpartum depression DOI
Zhihao Sheng, Qidong Liu, Yujie Song

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 241 - 252

Published: May 18, 2024

Language: Английский

Citations

5
Shared metabolic and neuroimmune mechanisms underlying Type 2 Diabetes Mellitus and Major Depressive Disorder DOI
Eduardo Duarte-Silva, Michel Gomes de Melo, Michaël Maes

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2021, Volume and Issue: 111, P. 110351 - 110351

Published: May 14, 2021

Language: Английский

Citations

32
High-Fat Diet Consumption in Adolescence Induces Emotional Behavior Alterations and Hippocampal Neurogenesis Deficits Accompanied by Excessive Microglial Activation DOI Open Access
Xiuting Yao, Chenxi Yang, Conghui Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8316 - 8316

Published: July 27, 2022

Adolescence is a developmental epoch characterized by massive neural circuit remodeling; thus, the brain particularly vulnerable to environmental influences during this period. Excessive high-fat diet (HFD) consumption, which very common among adolescents, has long been recognized as potent risk factor for multiple mood disorders, including depression and anxiety. However, precise mechanisms underlying of HFD consumption in adolescence on emotional health are far from clear. In present study, C57BL/6 mice were fed control (CD) or about 4 weeks postnatal day (P) 28 P60, spanning most period, then subjected behavioral assessments histological examinations. exhibited elevated levels anxiety, decreased hippocampal neurogenesis, excessive microglial activation ventral hippocampus. Furthermore, HFD-fed mice, microglia showed increased DCX+ inclusions, suggesting aberrant engulfment newborn neurons adolescents. To our knowledge, first observation that negative effects emotion neuroplasticity may be attributed at least part nascent neurons, extending understanding mechanism HFD-related affective disorders young people.

Language: Английский

Citations

22