Pharmaceutical wastewater as Emerging Contaminants (EC): Treatment technologies, impact on environment and human health

Energy Nexus, Journal Year: 2022, Volume and Issue: 6, P. 100076 - 100076

Published: April 26, 2022

A wide range of unregulated chemicals synthetic origin or derived from natural sources, which may be a contender for future regulations are called Emerging Contaminants (ECs). The concentration ECs ranges ng/L to μg/L, is comparatively smaller as compared other pollutants present in water and wastewater. Even though the environmental low, still possess great threat humans ecosystem. These compounds being widely studied due their potential health effects, pervasive nature, difficult degradation through conventional techniques. Pharmaceutical active (PhACs) pharmaceutical contaminants (PCs) one major groups can cause inimical effect on living organisms even at very lower concentration. don't degrade easily persistent longer periods environment stable structure. With increase demand Pharmaceuticals Personal Care Products (PPCPs), there has been sharp these bodies. This mainly inefficiency wastewater treatment plants removal PhACs. proper identification development techniques crucial recent times. review represents comprehensive summary PCs, various PCs an overview approaches systems available removal. Efficient effective methods useful completely eradicating making bodies safe use. So, investment capital time research beneficial future.

Language: Английский

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Metformin: update on mechanisms of action and repurposing potential

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(8), P. 460 - 476

Published: May 2, 2023

Language: Английский

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Bifunctional Electrocatalysts for Overall and Hybrid Water Splitting

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(7), P. 3694 - 3812

Published: March 22, 2024

Electrocatalytic water splitting driven by renewable electricity has been recognized as a promising approach for green hydrogen production. Different from conventional strategies in developing electrocatalysts the two half-reactions of (e.g., and oxygen evolution reactions, HER OER) separately, there growing interest designing bifunctional electrocatalysts, which are able to catalyze both OER. In addition, considering high overpotentials required OER while limited value produced oxygen, is another rapidly exploring alternative oxidation reactions replace hybrid toward energy-efficient generation. This Review begins with an introduction on fundamental aspects splitting, followed thorough discussion various physicochemical characterization techniques that frequently employed probing active sites, emphasis reconstruction during redox electrolysis. The design, synthesis, performance diverse based noble metals, nonprecious metal-free nanocarbons, overall acidic alkaline electrolytes, thoroughly summarized compared. Next, their application also presented, wherein anodic include sacrificing agents oxidation, pollutants oxidative degradation, organics upgrading. Finally, concise statement current challenges future opportunities presented hope guiding endeavors quest sustainable

Language: Английский

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Metformin: Is it a drug for all reasons and diseases?

Metabolism, Journal Year: 2022, Volume and Issue: 133, P. 155223 - 155223

Published: May 29, 2022

Metformin was first used to treat type 2 diabetes in the late 1950s and 2022 remains first-choice drug daily by approximately 150 million people. An accumulation of positive pre-clinical clinical data has stimulated interest re-purposing metformin a variety diseases including COVID-19. In polycystic ovary syndrome improves insulin sensitivity. 1 may help reduce dose. Meta-analysis from studies link reduction incidence cancer. Clinical trials, MILES (Metformin Longevity Study), TAME (Targeting Aging with Metformin), have been designed determine if can offset aging extend lifespan. Pre-clinical suggest that metformin, via suppression pro-inflammatory pathways, protection mitochondria vascular function, direct actions on neuronal stem cells, protect against neurodegenerative diseases. also studied for its anti-bacterial, -viral, -malaria efficacy. Collectively, these raise question: Is all diseases? It unclear as whether putative beneficial effects are secondary an anti-hyperglycemic insulin-sensitizing drug, or result other cellular actions, inhibition mTOR (mammalian target rapamycin), anti-viral actions. Clarification is sought ex vivo based use high concentrations be translated into benefits, they reflect 'Paracelsus' effect. The environmental impact no known metabolites, another emerging issue linked endocrine disruption fish, extensive T2D raised concerns over human reproduction. objectives this review to: 1) evaluate mechanism(s) action metformin; 2) analyze controversial evidence metformin's effectiveness treatment than diabetes; 3) assess reproducibility data, finally 4) reach informed conclusion reasons. We conclude primary benefits antihyperglycaemic secondarily contribute reduced risk number thereby enhancing healthspan. However, like improving endothelial function independent glucose homeostasis add therapeutic

Language: Английский

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Emerging contaminants: A One Health perspective

The Innovation, Journal Year: 2024, Volume and Issue: 5(4), P. 100612 - 100612

Published: March 13, 2024

Language: Английский

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Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations

Journal of Water Process Engineering, Journal Year: 2023, Volume and Issue: 52, P. 103490 - 103490

Published: Feb. 4, 2023

Language: Английский

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Membrane-based nanoconfined heterogeneous catalysis for water purification: A critical review✰

Water Research, Journal Year: 2023, Volume and Issue: 230, P. 119577 - 119577

Published: Jan. 5, 2023

Language: Английский

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Extracellular polymeric substances—antibiotics interaction in activated sludge: A review

Environmental Science and Ecotechnology, Journal Year: 2022, Volume and Issue: 13, P. 100212 - 100212

Published: Nov. 9, 2022

Antibiotics, the most frequently prescribed drugs, have been widely applied to prevent or cure human and veterinary diseases undoubtedly led massive releases into sewer networks wastewater treatment systems, a hotspot where occurrence transformation of antibiotic resistance take place. Extracellular polymeric substances (EPS), biopolymers secreted via microbial activity, play an important role in cell adhesion, nutrient retention, toxicity resistance. However, potential roles sludge EPS related removal antibiotics are still unclear. This work summarizes composition physicochemical characteristics state-of-the-art EPS, highlights critical removal, evaluates their defense performances under different exposures, analyzes typical factors that could affect sorption biotransformation behavior antibiotics. Next, interactions between genes analyzed. Future perspectives, especially engineering application for detection defense, also emphatically stressed.

Language: Английский

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Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 28, 2023

In recent ages, green nanotechnology has gained attraction in the synthesis of metallic nanoparticles due to their cost-effectiveness, simple preparation steps, and environmentally-friendly. present study, copper oxide (CuO NPs) were prepared using Parthenium hysterophorus whole plant aqueous extract as a reducing, stabilizing, capping agent. The CuO NPs characterized via UV-Vis Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), powder X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission (TEM), Dynamic Light Scattering (DLS). spectra showed surface plasmonic resonance band occur at 340 nm. FTIR analysis revealed presence secondary metabolites on NPs, with characteristic Cu-O stretching being identified 522 cm

Language: Английский

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Addressing chemical pollution in biodiversity research

Global Change Biology, Journal Year: 2023, Volume and Issue: 29(12), P. 3240 - 3255

Published: March 21, 2023

Abstract Climate change, biodiversity loss, and chemical pollution are planetary‐scale emergencies requiring urgent mitigation actions. As these “triple crises” deeply interlinked, they need to be tackled in an integrative manner. However, while climate change often studied together, as a global factor contributing worldwide loss has received much less attention research so far. Here, we review evidence showing that the multifaceted effects of anthropogenic chemicals environment posing growing threat ecosystems. Therefore, failure account for may significantly undermine success protection efforts. We argue progress understanding counteracting negative impact on requires collective efforts scientists from different disciplines, including but not limited ecology, ecotoxicology, environmental chemistry. Importantly, recent developments fields have now enabled comprehensive studies could efficiently address manifold interactions between Based their experience with intricate biodiversity, ecologists well equipped embrace additional challenge complexity through interdisciplinary collaborations. This offers unique opportunity jointly advance seminal frontier ecology facilitate development innovative solutions protection.

Language: Английский

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