In-situ multicore fibre-based pH mapping through obstacles in integrated microfluidic devices

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 3, 2024

Abstract Microfluidic systems with integrated sensors are ideal platforms to study and emulate processes such as complex multiphase flow reactive transport in porous media, numerical modeling of bulk medicine, engineering. Existing commercial optical fibre sensing used microfluidic devices based on single-core fibres, limiting the spatial resolution parameter measurements application scenarios. Here, we propose a multicore fibre-based pH system for in-situ mapping tens micrometer devices. The demonstration uses custom laser-manufactured glass (called further micromodels) consisting two round ports. micromodels comprise lintels injection various buffers an outlet. two-port facilitates solutions using independent pressure pumps. imaging provides information about environment from intensity distribution fluorescence emission sensor attached end facet, making use cores measurement channels. As proof-of-concept, performed through obstacles (glass rock beads), showing that particle features can be clearly distinguishable sensor.

Language: Английский

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Integrated Closed-loop Control of Bio-actuation for Proprioceptive Bio-hybrid Robots

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 2, 2024

Abstract Biohybrid robots are emergent soft that combine engineered artificial structures and living biosystems to exploit unique characteristics of biological cells tissues. Skeletal muscle tissue-based bio-actuators can respond externally applied stimuli, such as electrical fields. However, current bio-actuation systems rely on open-loop control strategies lack knowledge the actuator’s state. The regulation output force position bio-hybrid requires self-sensing with sensors paradigms. Here, we propose a soft, fiber-shaped mechanical sensor based composite piezoresistive properties efficiently integrates skeletal tissue senses its contracting states in cell culture environment presence After testing sensor’s insulation biocompatibility, characterized sensitivity for typical strains (<1%) proved ability detect motions from contractile constructs. Finally, showed response feed an autonomous system, thus demonstrating first proprioceptive robot sense contraction In addition inspiring intelligent implantable systems, informative biomedical models, other bioelectronic proposed technology will encourage exceed durability, design, portability limitations biohybrid confer them decisional autonomy, driving paradigm shift between robots. One Sentence Summary Integrating into enables proprioception.

Language: Английский

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Perfusable biohybrid designs for bioprinted skeletal muscle tissue

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 15, 2023

ABSTRACT Engineered, centimeter-scale skeletal muscle tissue (SMT) can mimic pathophysiology to study development, disease, regeneration, drug response, and motion. Macroscale SMT requires perfusable channels guarantee cell survival support elements enable mechanical stimulation uniaxial myofiber formation. Here, stable biohybrid designs of are realized via extrusion-based bioprinting an optimized polymeric blend based on gelatin methacryloyl sodium alginate, which be accurately co-printed with other inks. A microchannel network is designed functionally integrate anchors for insertion into a maturation culture template. The results demonstrate that ( i ) synthetic structures display highly coherent interfaces the living tissue; ii preserve cells from hypoxia all over scaffold volume; iii constructs undergo passive tension during matrix remodeling. Extrusion-based multimaterial our inks design realizes in vitro matured biomedical, nutritional, robotic applications.

Language: Английский

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Physics of smart active matter: integrating active matter and control to gain insights into living systems

Soft Matter, Journal Year: 2023, Volume and Issue: 19(23), P. 4204 - 4207

Published: Jan. 1, 2023

A confined active gas of collisional flapping robots that each sense and respond to light. Above some threshold a robot freezes its configuration which generates locomotion the collective toward light source although no individual can translate on own.

Language: Английский

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Biosyncretic Robots Actuated by Living Materials

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 9(1)

Published: Nov. 10, 2023

Abstract In recent years, biosyncretic robots, a novel type of robot that integrates living and artificial materials, have gained significant attention. Biosyncretic robots are expected to leverage the advantages provided by materials offer new approach address challenges faced traditional such as biocompatibility, intrinsic safety, miniaturization. Therefore, this review aims provide an overview current state development robots. First, existing research on based commonly used is systematically categorized introduced, including cardiomyocytes, skeletal muscle cells, insect dorsal vascular tissue, microorganisms. Subsequently, their potential in fields vivo medical diagnosis treatment, organ‐on‐a‐chip, tissue engineering, environmental monitoring, postdisaster rescue detail also discussed. Finally, robotic research, establishing theoretical models, fabrication, cultivation, maintenance controllability, versatility, material, entering human body or leaving laboratory, examined. This summarizes cutting‐edge progress provides insights into future development.

Language: Английский

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