Life, Journal Year: 2025, Volume and Issue: 15(2), P. 247 - 247
Published: Feb. 6, 2025
From the early identification of severe respiratory cases unknown etiology in Wuhan, China, late 2019, virology research has played an important role understanding, management, and prevention COVID-19 pandemic [...]
Language: Английский
Annual Review of Virology, Journal Year: 2024, Volume and Issue: 11(1), P. 21 - 42
Published: April 18, 2024
The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet seemingly little resolution. I review the scientific evidence on its subsequent spread through human population. available data clearly point to a natural zoonotic emergence within, or closely linked to, Huanan Seafood Wholesale Market in Wuhan. There is no direct linking laboratory work conducted at Wuhan Institute Virology. global was characterized by gradual adaptation humans, with dual increases transmissibility virulence until Omicron variant. Of note been frequent transmission from humans other animals, marking it as strongly host generalist virus. Unless lessons are learned, inevitable that more events leading epidemics pandemics will plague populations.
Language: Английский
Citations
32
Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5468 - 5482.e11
Published: Sept. 1, 2024
Language: Английский
Citations
26
Research Directions One Health, Journal Year: 2024, Volume and Issue: 2
Published: Jan. 1, 2024
Abstract Integrated wildlife monitoring (IWM) combines infection dynamics and the ecology of populations, including aspects defining host community network. Developing implementing IWM is a worldwide priority that faces major constraints biases should be considered addressed when these systems. We identify eleven main limitations in establishment IWM, which could summarized into funding lack harmonization information exchange. The solutions proposed to overcome comprise: (i) selecting indicator species through network analysis, (ii) identifying key pathogens investigate monitor, potentially nonspecific health markers, (iii) improve standardize harmonized methodologies can applied as well communication among stakeholders across within countries, (iv) integration new noninvasive technologies (e.g., camera trapping (CT) environmental nucleic acid detection) tools are under ongoing research artificial intelligence speed-up CT analyses, microfluidic polymerase chain reaction sample volume constraints, or filter paper samples facilitate transport). Achieving optimizing must allows drivers epidemics predicting trends changes disease population before pathogen crosses interspecific barriers.
Language: Английский
Citations
16
The Lancet, Journal Year: 2023, Volume and Issue: 401(10376), P. 530 - 533
Published: Jan. 20, 2023
Language: Английский
Citations
36
Journal of Clinical Microbiology, Journal Year: 2023, Volume and Issue: 61(7)
Published: April 26, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is notable both for its impact on global public health as well well-publicized transmissibility to other species of animals. Infection incidental animal hosts concerning because possible emergence novel variants due viral mutation. Species that are susceptible SARS-CoV-2 include domestic and nondomestic cats, dogs, white-tailed deer, mink, golden hamsters, among others. We detail origins transmission humans, the ecological molecular mechanisms needed virus establish infection in humans from highlight examples spillover, spillback, secondary demonstrating breadth variability current events have been documented domestic, captive, wild Lastly, we turn our focus importance potential reservoirs sources variant can profound effects human population. note a One Health approach emphasizing surveillance animals certain environments using interdisciplinary collaboration encouraged manage disease surveillance, regulation trade testing, vaccine development will mitigate further outbreaks. These efforts minimize spread advance knowledge prevent future emerging infectious diseases.
Language: Английский
Citations
25
The Lancet Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 100939 - 100939
Published: Aug. 1, 2024
SummaryWastewater surveillance holds great promise as a sensitive method to detect spillover of zoonotic infections and early pandemic emergence, thereby informing risk mitigation public health response. Known viruses with potential are shed in human stool or urine, both, the experiences SARS-CoV-2, monkeypox virus, Zika virus highlight feasibility community-based wastewater for that have different transmission routes. We reviewed shedding data prototype representing viral families concern estimate likely sensitivity compared clinical surveillance. examined how on detection, together genetic sequences animal faecal biomarkers, could be used identify adaptation. The opportunities challenges associated global prevention pandemics described this Personal View, focusing low-income middle-income countries, where emergence is highest. propose research agenda ensure an equitable sustainable solution these challenges.
Language: Английский
Citations
14
The Lancet, Journal Year: 2024, Volume and Issue: 403(10438), P. 1729 - 1731
Published: April 8, 2024
Language: Английский
Citations
12
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 17, 2024
Abstract Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome and defy established structure-function paradigm. Because IDRs often have limited positional sequence conservation, functional classification using standard bioinformatics is generally not possible. Here, we show that evolutionarily conserved molecular features intrinsically (IDR-ome), termed evolutionary signatures, enable prediction IDR functions. Hierarchical clustering IDR-ome based on signatures reveals strong enrichments for frequently studied functions in transcription RNA processing, as well diverse, rarely functions, ranging from sub-cellular localization biomolecular condensates to cellular signaling, transmembrane transport, constitution cytoskeleton. We exploit information encoded within conservation propose annotations every proteome, inspect correlate with different discover co-occurring scale. Further, identify patterns proteins unknown function disease-risk genes conditions such cancer developmental disorders. Our map should be a valuable resource aids discovery new biology.
Language: Английский
Citations
10
Science in One Health, Journal Year: 2024, Volume and Issue: 3, P. 100067 - 100067
Published: Jan. 1, 2024
To detect and respond to emerging diseases more effectively, an integrated surveillance strategy needs be applied both human animal health. Current programs in Asian countries operate separately for the two sectors are principally concerned with detection of events that represent a short-term disease threat. It is not realistic either invest only efforts diseases, or rely solely on event-based surveillance. A comprehensive needed, concurrently investigating managing endemic zoonoses, studying evolving which change their character importance due influences such as demographic climatic change, enhancing understanding factors likely influence emergence new pathogens. This requires utilisation additional investigation tools have become available recent years but yet being used full effect. As there no fully formed blueprint can countries. Hence three-step pathway proposed move towards goal One Health response.
Language: Английский
Citations
8
Journal of Virology, Journal Year: 2024, Volume and Issue: 98(2)
Published: Jan. 16, 2024
Fast detection and rapid intervention are crucial to mitigate risks of pathogen emergence, spillover spread—every second counts. However, comprehensive, active, longitudinal surveillance systems at high-risk interfaces that provide real-time data for action remain lacking. This paper proposes "smart market" harnessing cutting-edge tools a range sampling techniques, including wastewater air collection, multiplex assays, metagenomic sequencing. Coupled with robust response pathways, these could better enable Early Warning bolster prevention efforts.
Language: Английский
Citations
7