Precision Mapping of the Default Network Reveals Common and Distinct (Inter)activity for Autobiographical Memory and Theory of Mind DOI
Colleen Hughes, Roni Setton, Laetitia Mwilambwe-Tshilobo

et al.

Journal of Neurophysiology, Journal Year: 2024, Volume and Issue: 132(2), P. 375 - 388

Published: Aug. 1, 2024

The default network is widely implicated as a common neural substrate for self-generated thought, such remembering one's past (autobiographical memory) and imagining the thoughts feelings of others (theory mind). Findings that comprises subnetworks regions, some commonly distinctly involved across processes, suggest own experiences inform their understanding others. With advent precision functional MRI (fMRI) methods, however, it unclear if this shared observed instead due to traditional group analysis methods. We investigated possibility using novel combination methodological strategies. Twenty-three participants underwent multi-echo resting-state task fMRI. used scans conduct cortical parcellation sensitive individual variation while preserving our ability analysis. Using multivariate analyses, we assessed activation connectivity profiles regions engaged in autobiographical memory, theory mind, or sensorimotor control condition. Across network, stronger activity associated with both memory mind compared Nonetheless, also showed preferential either experimental condition, line work. results similarly indicated distinct profiles. Our support two theoretically important studied domains social cognition, evoke aspects even when ensuring high fidelity individual-specific characteristics.

Language: Английский

Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis DOI
Katrina Aberizk, Esra Sefik, Qingyue Yuan

et al.

Schizophrenia Research, Journal Year: 2025, Volume and Issue: 277, P. 151 - 158

Published: March 1, 2025

Language: Английский

Citations

2
Conscientiousness associated with efficiency of the salience/ventral attention network: Replication in three samples using individualized parcellation DOI Creative Commons
Tyler A. Sassenberg, Philip Burton, Laetitia Mwilambwe-Tshilobo

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 272, P. 120081 - 120081

Published: April 1, 2023

Conscientiousness, and related constructs impulsivity self-control, have been to structural functional properties of regions in the prefrontal cortex (PFC) anterior insula. Network-based conceptions brain function suggest that these belong a single large-scale network, labeled salience/ventral attention network (SVAN). The current study tested associations between conscientiousness resting-state connectivity this using two community samples (N's = 244 239) data from Human Connectome Project (N 1000). Individualized parcellation was used improve localization accuracy facilitate replication. Functional measured an index efficiency, graph theoretical measure quantifying capacity for parallel information transfer within network. Efficiency set parcels SVAN significantly associated with all samples. Findings are consistent theory as variation neural networks underlying effective prioritization goals.

Language: Английский

Citations

36
Effects of Healthy and Neuropathological Aging on Autobiographical Memory: A Meta-Analysis of Studies Using the Autobiographical Interview DOI
Stephanie Simpson,

Mona Eskandaripour,

Brian Levine

et al.

The Journals of Gerontology Series B, Journal Year: 2023, Volume and Issue: 78(10), P. 1617 - 1624

Published: May 24, 2023

A meta-analytic review was conducted to assess the effects of healthy aging, amnestic mild cognitive impairment (MCI), and Alzheimer's disease (AD) on naturalistic autobiographical memory using Autobiographical Interview, a widely used, standardized assessment that derives measures internal (episodic) external (nonepisodic) details from freely recalled narratives.

Language: Английский

Citations

20
Structure–Function Interactions in the Hippocampus and Prefrontal Cortex Are Associated with Episodic Memory in Healthy Aging DOI Creative Commons
Jamie Snytte, Roni Setton, Laetitia Mwilambwe-Tshilobo

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(3), P. ENEURO.0418 - 23.2023

Published: March 1, 2024

Aging comes with declines in episodic memory. Memory decline is accompanied by structural and functional alterations within key brain regions, including the hippocampus lateral prefrontal cortex, as well their affiliated default frontoparietal control networks. Most studies have examined how or differences relate to memory independently. Here we implemented a multimodal, multivariate approach investigate interactions between individual integrity connectivity performance healthy aging. In sample of younger ( N = 111; mean age, 22.11 years) older 78; 67.29 adults, analyzed MRI multiecho resting-state fMRI data. Participants completed measures list recall (free words from list), associative (cued paired words), source trial type, sensory modality which word was presented). The findings revealed that greater posterior middle frontal gyrus were linked pattern increased within-network connectivity, together related better adulthood. Critically, adults displayed context decreased hippocampal volumes when reorganization. This reorganization characterized pruning connections limbic Our work provides insight into neural mechanisms underlie age-related compensation, revealing architecture associated aging tied cortex.

Language: Английский

Citations

7
Abnormal Brain Structure Is Associated with Social and Communication Deficits in Children with Autism Spectrum Disorder: A Voxel-Based Morphometry Analysis DOI Creative Commons
Mingxiang Xu,

Xing‐Da Ju

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(5), P. 779 - 779

Published: May 10, 2023

Structural magnetic resonance imaging (sMRI) studies have shown abnormalities in the brain structure of ASD patients, but relationship between structural changes and social communication problems is still unclear. This study aims to explore mechanisms clinical dysfunction children through voxel-based morphometry (VBM). After screening T1 images from Autism Brain Imaging Data Exchange (ABIDE) database, 98 aged 8-12 years old with were matched 105 typical development (TD). Firstly, this compared differences gray matter volume (GMV) two groups. Then, evaluated GMV subtotal score communications interaction on Diagnostic Observation Schedule (ADOS) children. Research has found that abnormal structures include midbrain, pontine, bilateral hippocampus, left parahippocampal gyrus, superior temporal pole, middle gyrus occipital gyrus. In addition, children, ADOS only significantly positively correlated summary, abnormal, different related specific regions.

Language: Английский

Citations

12
The Self-Awareness Brain Network: Construction, Characterization, and Alterations in Schizophrenia and Major Depressive Disorder DOI Creative Commons
Xiaoluan Xia, Fei Gao,

Shiyang Xu

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121205 - 121205

Published: April 1, 2025

Self-awareness (SA) research is crucial for understanding cognition, social behavior, mental health, and education, but SA's underlying network architecture, particularly connectivity patterns, remains largely uncharted. We integrated meta-analytic findings with connectivity-behavior correlation analyses to systematically identify SA-related regions connections in healthy adults. Edge-weighted networks capturing public, private, composite SA dimensions were established, where weights represented strengths between tractography-derived structural connectivities levels quantified through behavioral assessments. Then, multilevel extracted across a spectrum of thresholds. Robust full-threshold revealed their hierarchical continuum encompassing distinct lateralization topological transitions, characteristic hourglass-like architectures. Pathological analysis demonstrated disruptions schizophrenia (SZ) major depressive disorder (MDD): approximately 40% altered SZ 20% MDD, 90% MDD alterations overlapping SZ. While disease-specific shared also observed network-level properties, the core framework remained preserved both disorders. Collectively, these significantly advanced our neurobiological substrates pathological deviations.

Language: Английский

Citations

0
Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes DOI Creative Commons
Dongsheng Zhang, Yang Huang, Shasha Liu

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2023, Volume and Issue: 10(12), P. 2305 - 2315

Published: Oct. 12, 2023

Abstract Objective We aimed to reveal the role of structural and functional alterations cingulate gyrus in early cognitive impairment Type 2 diabetes mellitus (T2DM) patients. Methods Fifty‐six T2DM patients 60 healthy controls (HCs) underwent a neuropsychological assessment sagittal three‐dimensional T1‐weighted resting‐state MRI. Differences cortical thickness cortex connectivity (FC) nine subregions whole brain were compared between HCs. Correlation analysis was performed FC participants' clinical/cognitive variables. Results The not significantly different However, showed lower pregenual ACC (pACC) bilateral hippocampus, higher pACC lateral prefrontal (LPFC) left precentral gyrus, retrosplenial (RSC) right cerebellar Crus I. hippocampus negatively correlated with LPFC ( r = −0.306, p 0.022). Interpretation RSC show dysfunctional before appearance abnormalities Abnormal may imply neural compensatory mechanism for memory function. These findings provide valuable information new directions possible interventions T2DM‐related impairment.

Language: Английский

Citations

10
Behavioral representations within the endogenous dual attentional pathways during audiovisual integration processing DOI Creative Commons

Zhongtian Guan,

Mingli Yan,

Miao He

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 11, 2025

Introduction Audiovisual integration processes are modulated by top-down attention and may involve different neural mechanisms under spatial, temporal, neutral properties, which externally manifested subjects adopting cognitive strategies. Composite behavioral indicators able to assess the balance between speed accuracy when perform a task, thus further revealing representations of tasks. However, strategies involved in audiovisual endogenous attentional modulation unclear, particular, functional relationship dorsal ventral pathways still needs be thoroughly investigated. Methods We design only auditory (A), visual (V), (VA) tasks based on classical Posner paradigm with temporal cues for indicators, brain activation, their correlations. Results Our results showed significant differences performance tasks, weaker dual-channel task than single-channel task. The consistent activation frontal eye field, inferior parietal lobule, supplementary motor area, superior gyrus, middle occipital gyrus cuneus. pathway is mainly associated spatial processing executive control, while object recognition semantic processing. In correlation analyses, proportions correct responses (PC) wider range results. Spatio-temporal mobilized more resources influenced execution Inverse efficiency score (IES) revealed energy expenditure whereas rate-correct (RCS) inter-task response efficiency. Linear integrated speed–accuracy (LISAS) balanced (BIS) speed-accuracy our Conclusion findings emphasize synergy functions dynamic pathways, contribute management flexibility

Language: Английский

Citations

0
Taking stock of the past: A psychometric evaluation of the Autobiographical Interview DOI Open Access

Amber W. Lockrow,

Roni Setton,

Karen A.P. Spreng

et al.

Behavior Research Methods, Journal Year: 2023, Volume and Issue: 56(2), P. 1002 - 1038

Published: March 21, 2023

Language: Английский

Citations

9
Altered brain function in classical trigeminal neuralgia patients: ALFF, ReHo, and DC static- and dynamic-frequency study DOI

Xiuhong Ge,

Luoyu Wang,

Juncheng Yan

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 27, 2023

Abstract The present study aimed to clarify the brain function of classical trigeminal neuralgia (CTN) by analyzing 77 CTN patients and age- gender-matched 73 healthy controls (HCs) based on three frequency bands static dynamic amplitude low-frequency fluctuation, regional homogeneity, degree centrality (sALFF, sReHo, sDC, dALFF, dReHo, dDC). Compared HCs, number altered regions was different in bands, band most followed slow-4 patients. Cerrelellum_8_L (sReHo), Cerrelellum_8_R (sDC), Calcarine_R Caudate_R (sDC) were found only band, while Precuneus_L (sALFF) Frontal_Inf_Tri_L (sReHo) band. Except for above six regions, others overlapped bands. seriously affects mental health patients, some are correlated with clinical parameters. indicators complementary changing showed specificity. slow-5 is more consistent which could be valuable exploring pathophysiology CTN.

Language: Английский

Citations

9