Pharmaceuticals
and
personal
care
products
(PPCPs)
compounds
are
vital
components
of
daily
life
modern
health
care.
Over
the
past
20–25
years,
a
substantial
amount
work
has
been
done
to
elucidate
occurrence,
bioaccumulation,
fate,
risks
PPCPs
in
environment.
The
ubiquity
most
environment
their
potential
deleterious
effects
on
ecological
human
have
engaged
community
scientists
government
regulators.
Nontarget
organisms
continuously
exposed
multiple
PPCP
compounds,
evidence
for
underestimated
toxicity
from
such
mixtures
is
mounting.
Yet,
increasing
research
around
world
still
focuses
overwhelmingly
molecular
mechanism
single
PPCP,
scientific
about
combined
limited
date.
This
chapter
provides
an
overview
"state-of-the-art"
literature
data
mechanisms
PPCPs,
with
special
emphasis
mixture
scenarios.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(11), P. 1584 - 1584
Published: Nov. 2, 2023
Antibiotic
resistance
patterns
of
the
major
human
periodontal
pathogen
Porphyromonas
gingivalis
were
assessed
over
a
20-year
period
in
United
States.
Subgingival
P.
was
cultured
pre-treatment
from
2193
severe
periodontitis
patients
during
three
time
periods:
1999-2000
(936
patients),
2009-2010
(685
and
2019-2020
(572
patients).
The
clinical
isolates
tested
for
vitro
to
4
mg/L
clindamycin
doxycycline,
8
amoxicillin,
16
metronidazole,
with
post
hoc
combination
data
metronidazole
plus
amoxicillin.
Clindamycin-resistant
significantly
more
prevalent
(9.1%
patients)
(9.3%;
15-fold
increase)
as
compared
(0.6%).
amoxicillin
also
increased
0.1%
1.3%
2.8%
(28-fold
2019-2020.
doxycycline
low
(≤0.5%
prevalence),
statistically
unchanged,
period.
These
findings
are
first
reveal
marked
increases
20
years
clindamycin-resistant
amoxicillin-resistant
States
patients.
Increased
antibiotic
other
periodontitis-associated
bacteria
threatens
efficacy
antimicrobial
chemotherapy.
ACS ES&T Water,
Journal Year:
2024,
Volume and Issue:
4(4), P. 1701 - 1710
Published: March 6, 2024
Nonantibiotic
pharmaceuticals
are
widely
used
to
treat
various
human
diseases
and
can
also
be
ubiquitously
detected
as
emerging
contaminants
in
the
environment,
thus
coexisting
with
environmental
bacteria.
Previous
studies
have
shown
that
several
nonantibiotic
trigger
mutation
promote
horizontal
transfer
of
antibiotic
resistance
genes
between
However,
it
is
still
unclear
whether
an
antibiotic-like
antimicrobial
activity
against
In
this
study,
we
investigated
effects
four
typical
(gemfibrozil,
ibuprofen,
propranolol,
sertraline)
bacteria
evolution
bacterial
when
challenged
these
pharmaceuticals.
Surprisingly,
all
exhibit
antibacterial
through
a
mechanism
similar
antibiotics.
They
increase
reactive
oxygen
species
production
enhance
membrane
permeability
up
2.7-
2.4-fold,
respectively.
The
expressions
sodA,
sodB,
recA
related
detoxification
SOS
response
were
upregulated.
We
found
upregulate
expression
efflux
pump
gene
tolC
2.5-fold
resistance.
This
study
provides
insights
into
role
emergence
highlights
negative
on
Annals of the New York Academy of Sciences,
Journal Year:
2023,
Volume and Issue:
1524(1), P. 10 - 16
Published: April 5, 2023
Abstract
The
gut
microbiota
modulates
neurobiological
activity
in
various
animal
lineages.
This
is
often
proposed
to
occur
through
interactions
with
neurotransmitters
and
other
neuromodulatory
molecules
the
host.
Our
commentary
will
discuss
recent
research
that
establishes
microbiota–neurotransmitter
connections,
gaps
current
understanding,
outstanding
questions
may
guide
future
advances
field
of
microbiota–nervous
system
interactions.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 9, 2024
Current
treatments
for
chronic
diarrhea
have
limited
efficacy
and
several
side
effects.
Probiotics
the
potential
to
alleviate
symptoms
of
diarrhea.
This
randomized,
double-blind,
placebo-controlled
trial
evaluates
effects
administering
probiotic
Lactiplantibacillus
plantarum
P9
(P9)
strain
in
young
adults
with
(Clinical
Trial
Registration
Number:
ChiCTR2000038410).
The
intervention
period
lasts
28
days,
followed
by
a
14-day
post-intervention
period.
Participants
are
randomized
into
(n
=
93)
placebo
96)
groups,
170
individuals
completing
double-blind
phase
85
per
group).
primary
endpoint
is
symptom
severity
score.
Both
intention-to-treat
189)
per-protocol
170)
analyses
reveal
modest
yet
statistically
significant
reduction
compared
group
(20.0%,
P
0.050;
21.4%,
0.048,
respectively).
In
conclusion,
results
this
study
support
use
probiotics
managing
adults.
However,
lack
blood
parameter
assessment
short
represent
limitations
study.
Pharmaceuticals
and
personal
care
products
(PPCPs)
compounds
are
vital
components
of
daily
life
modern
health
care.
Over
the
past
20–25
years,
a
substantial
amount
work
has
been
done
to
elucidate
occurrence,
bioaccumulation,
fate,
risks
PPCPs
in
environment.
The
ubiquity
most
environment
their
potential
deleterious
effects
on
ecological
human
have
engaged
community
scientists
government
regulators.
Nontarget
organisms
continuously
exposed
multiple
PPCP
compounds,
evidence
for
underestimated
toxicity
from
such
mixtures
is
mounting.
Yet,
increasing
research
around
world
still
focuses
overwhelmingly
molecular
mechanism
single
PPCP,
scientific
about
combined
limited
date.
This
chapter
provides
an
overview
"state-of-the-art"
literature
data
mechanisms
PPCPs,
with
special
emphasis
mixture
scenarios.
