Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163576 - 163576
Published: May 1, 2025
Language: Английский
Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101347 - 101347
Published: July 30, 2024
Language: Английский
Citations
6
ACS Nano, Journal Year: 2024, Volume and Issue: 18(23), P. 14877 - 14892
Published: May 29, 2024
Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically "cold" tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations an situ formed hydrogel scaffold treat accessible tumors locally stimulate systemic against metastatic lesions. The nanoparticles encapsulate poly(ε-caprolactone)-derived cytotoxic chemotherapy adjuvant of Toll-like receptor 7/8 through a reactive oxygen species (ROS)-cleavable linker that can be self-activated by coassembled neighboring photosensitizer following near-infrared (NIR) laser irradiation. Further development results syringeable, NIR light-responsive, immunogenic (iGEL) implanted peritumorally deposited into surgical bed. Upon irradiation, generated ROS induces iGEL degradation bond cleavage polymer–drug conjugates, triggering cell death cascade cancer cells spontaneously releasing encapsulated agents rewire Notably, upon application preclinical models melanoma triple-negative breast cancer, which are aggressive refractory immunotherapy, durable remission established tumors, extends postsurgical tumor-free survival, inhibits burden. result this study is administrable for host improve immunotherapeutic efficacy with minimal off-target side effects.
Language: Английский
Citations
5
Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 229 - 229
Published: Aug. 16, 2024
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted much attention as potential therapeutic strategies. A systematic review and analysis must be carried out to investigate effect mannose modification on immune response nanoparticles in regulating microenvironment, well explore its clinical application therapy. Despite advantages achieving an effective microenvironment remains a challenge. Tumor escape overexpression immunosuppressive factors limit application. Therefore, our explored how intervene mechanism through use mannan-decorated lipid calcium phosphate improve efficacy immunotherapy patients with tumors provide new ideas strategies for field
Language: Английский
Citations
5
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 780 - 796
Published: March 21, 2024
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 18, 2024
Photoagents with ultra-high near-infrared II (NIR-II) light energy conversion efficiency hold great promise in tumor phototherapy due to their ability penetrate deeper tissues and minimize damage surrounding healthy cells. However, the development of NIR-II photoagents remain challenging. In this study, an all-fused-ring quinoidal acceptor-donor-acceptor (A-D-A) molecule, SKCN, a BTP core is synthesized, nanoparticles named FA-SNPs are prepared. The unique structure enhances π-electron delocalization bond length uniformity, significantly reducing bandgap resulting strong absorption, high molar extinction coefficient, photothermal 75.14%. Enhanced molecular rigidity also facilitates efficient transfer oxygen, boosting reactive oxygen species generation. By incorporating immunomodulator R848, FA-SRNPs further developed, effectively modulating immune microenvironment by Tregs M-MDSCs infiltration, promoting dendritic cell maturation, M1 macrophage polarization, activating CD8+ T cells NK Comprehensive studies using orthotopic ovarian cancer models demonstrated targeting, photoacoustic imaging capabilities, significant suppression metastasis inhibition, showing excellent therapeutic efficacy breast model. This study provides evidence for potential application A-D-A molecules photoimmunotherapy.
Language: Английский
Citations
4
Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123096 - 123096
Published: Jan. 8, 2025
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 17, 2025
Cancer continues to be one of the leading causes death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, surgery have limitations. RNA therapy vaccines hold considerable promise an alternative for their ability enable personalized with improved efficacy reduced side effects. The principal approach is induce a specific immune response against cells. However, major challenge in immunotherapy predict which patients will respond treatment monitor vaccine during treatment. Theragnostics, integration diagnostic therapeutic capabilities into single hybrid platform system, has potential address these challenges by enabling real-time monitoring while allowing endogenously controlled adjustments. In this article, we review current state-of-the-art theragnostics including imaging agents, biomarkers, other tools relevant cancer, application development personalization. We also discuss opportunities further clinical translation vaccines.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 757 - 767
Published: Jan. 25, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123170 - 123170
Published: Feb. 5, 2025
Language: Английский
Citations
0