Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross‐Species Systematic Review DOI
Michelle D. Graf, Nicolas Murgueitio, Sarah C. Vogel

et al.

Developmental Psychobiology, Journal Year: 2024, Volume and Issue: 67(1)

Published: Dec. 5, 2024

ABSTRACT The prenatal period is a critical developmental juncture with enduring effects on offspring health trajectories. An individual's gut microbiome associated and outcomes across the lifespan. Prenatal stress can disrupt an infant's microbiome, thereby increasing susceptibility to adverse outcomes. This cross‐species systematic review investigates whether maternal affects offspring's microbiome. study analyzes 19 empirical, peer‐reviewed research articles, including humans, rodents, non‐human primates, that included as primary independent variable characteristics outcome variable. appeared correlate differences in beta diversity specific microbial taxa, but not alpha diversity. positively correlated Proteobacteria, Bacteroidaceae, Lachnospiraceae, Prevotellaceae, Bacteroides , Serratia . Negative correlations were observed for Actinobacteria, Enterobacteriaceae, Streptococcaceae, Bifidobacteria, Eggerthella, Parabacteroides Streptococcus Evidence direction of association between Lactobacillus was mixed. synthesis findings limited by design, operationalization timing stress, infant sampling, analysis methods.

Language: Английский

The role of gut microbiota in intestinal disease: from an oxidative stress perspective DOI Creative Commons

Yiqi Sun,

Xurui Wang,

Lei Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the microbiota dysregulated, especially several bacterial metabolites are present. Although healthy plays a vital role in defending against excessive stress, disease influenced by ROS, this process controlled immunological responses, DNA damage, inflammation. In review, we discuss relationship between from an perspective. addition, also provide summary most recent therapeutic approaches for preventing or treating modifying microbiota.

Language: Английский

Citations

35

The gut–airway microbiome axis in health and respiratory diseases DOI
Mustafa Özçam, Susan V. Lynch

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(8), P. 492 - 506

Published: May 22, 2024

Language: Английский

Citations

25

The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment DOI Creative Commons
Daniel Freimer, Tony T. Yang, Tiffany C. Ho

et al.

Brain Behavior & Immunity - Health, Journal Year: 2022, Volume and Issue: 26, P. 100541 - 100541

Published: Oct. 30, 2022

Stress-associated disruptions in the development of frontolimbic regions may play a critical role emergence adolescent-onset depression. These are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA is hyperactive adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. Microbiome-Gut-Brain (MGB) an important pathway through which stress dysregulates HPA-axis activity thus exerts deleterious effects on brain. Probiotic agents, alter gut microbiota composition by introducing bacterial strains with beneficial physiological effects, normalize aberrant reduce depressive symptoms both animal studies adult clinical trials. While utility agents treating or preventing depression remains largely unexplored, recent data suggest existence window during probiotics be especially efficacious reducing compared observed populations. In this review, we outline evidence probiotic use development, providing novel means improving among

Language: Английский

Citations

30

Infant gut microbiota contributes to cognitive performance in mice DOI Creative Commons
Tomás Cerdó, Alicia Ruíz, Inmaculada Acuña

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(12), P. 1974 - 1988.e4

Published: Dec. 1, 2023

Language: Английский

Citations

17

Prenatal Stress Impacts Foetal Neurodevelopment: Temporal Windows of Gestational Vulnerability DOI
James M. Collins, James Keane, Clara Deady

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105793 - 105793

Published: July 5, 2024

Language: Английский

Citations

5

Early-life gut microbiome development and its potential long-term impact on health outcomes DOI Open Access
Alejandro Borrego-Ruiz, Juan J. Borrego

Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 17, 2025

The initial gut colonization of the infant plays a pivotal role in shaping immune system, developing intestinal tract, and influencing host metabolism, all which are strongly influenced by several determinants, such as gestational age at birth, mode delivery, neonatal feeding practices, early-life stress (ELS), exposure to perinatal antibiotics. However, resulting microbiome (GM) dysbiosis may alter this developmental programming, leading long-term adverse health outcomes. This narrative review synthesizes current knowledge on GM development its impact health. Specifically, it addresses how affect trajectory physiological processes, predisposing individuals conditions allergic diseases, metabolic disorders, type 1 diabetes, inflammatory bowel atherosclerotic cardiovascular diseases. In addition, examines influence probiotic prebiotic supplementation during pregnancy early life composition, well ELS-induced mental Recent research suggests that microbiota initiates long-lasting effects, inadequate or insufficient microbial triggers responses associated with conditions. Although studies have reported connection between ELS both prenatal postnatal periods, unified signature linked either remains be fully elucidated. Thus, future needed establish causality determine whether modifiable factors affecting could targeted improve health, especially children exposed contextual

Language: Английский

Citations

0

The biological and sociological implications of diversity, equity, and inclusion (DEI): life within microbiomes and on earth DOI
David A. Lawrence,

Brandon O’Sullivan,

Joerg Graf

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 29, 2025

From a biological point of view, Diversity, Equity, and Inclusion (DEI) are important at multiple levels, which include our genetics, microbiomes, diets, all organ system interactions. Considering only DEI's sociological aspects is equivalent to the error "throwing out baby with bath water." Variances in microbial diversity within microbiomes might affect health through systemic interactions affecting metabolites, maintaining immune homeostasis, wound healing cellular damage from an infection, physical stress, or psychological trauma. An imbalance cell subsets, both innate adaptive, microbes any lead more excessive inflammation oxidative stress less regulation. The dysregulation may occur due loss endometrial barriers enabling spread microbes, environmental pollutants, allergens. Heat waves, sleep deprivation, increased prevalence pollutants such as polychlorinated biphenyls, weaken endothelial barriers, be responsible for enhanced stresses. Leakage useful gut microbiota into periphery initiate inflammatory responses, altered microbiome gut-brain axis that influences mental health.

Language: Английский

Citations

0

Transgenerational effects of early life stress on the fecal microbiota in mice DOI Creative Commons

Nize Otaru,

Lola Kourouma,

Benoı̂t Pugin

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 31, 2024

Abstract Stress in early life can affect the progeny and increase risk to develop psychiatric cardiometabolic diseases across generations. The cross-generational effects of stress have been modeled mice demonstrated be associated with epigenetic factors germline. While is known gut microbial features, whether its persist passed not well defined. Here we show that postnatal shifts fecal composition (binary Jaccard index) throughout life, including abundance eight amplicon sequencing variants (ASVs). Further on composition, structure (weighted index), 16 ASVs are detected two These accompanied by changes bacterial metabolites any generation. results suggest community induced traumatic perpetuated from exposed parent offspring.

Language: Английский

Citations

3

Home-ics: how experiences of the home impact biology and child neurodevelopmental outcomes DOI
Rhandi Christensen, Steven P. Miller, Noha Gomaa

et al.

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

3

The Maternal Microbiome as a Map to Understanding the Impact of Prenatal Stress on Offspring Psychiatric Health DOI
Mary Kimmel, Branden Verosky, Helen J. Chen

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(4), P. 300 - 309

Published: Nov. 30, 2023

Language: Английский

Citations

8