Developmental Psychobiology,
Journal Year:
2024,
Volume and Issue:
67(1)
Published: Dec. 5, 2024
ABSTRACT
The
prenatal
period
is
a
critical
developmental
juncture
with
enduring
effects
on
offspring
health
trajectories.
An
individual's
gut
microbiome
associated
and
outcomes
across
the
lifespan.
Prenatal
stress
can
disrupt
an
infant's
microbiome,
thereby
increasing
susceptibility
to
adverse
outcomes.
This
cross‐species
systematic
review
investigates
whether
maternal
affects
offspring's
microbiome.
study
analyzes
19
empirical,
peer‐reviewed
research
articles,
including
humans,
rodents,
non‐human
primates,
that
included
as
primary
independent
variable
characteristics
outcome
variable.
appeared
correlate
differences
in
beta
diversity
specific
microbial
taxa,
but
not
alpha
diversity.
positively
correlated
Proteobacteria,
Bacteroidaceae,
Lachnospiraceae,
Prevotellaceae,
Bacteroides
,
Serratia
.
Negative
correlations
were
observed
for
Actinobacteria,
Enterobacteriaceae,
Streptococcaceae,
Bifidobacteria,
Eggerthella,
Parabacteroides
Streptococcus
Evidence
direction
of
association
between
Lactobacillus
was
mixed.
synthesis
findings
limited
by
design,
operationalization
timing
stress,
infant
sampling,
analysis
methods.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Brain Behavior & Immunity - Health,
Journal Year:
2022,
Volume and Issue:
26, P. 100541 - 100541
Published: Oct. 30, 2022
Stress-associated
disruptions
in
the
development
of
frontolimbic
regions
may
play
a
critical
role
emergence
adolescent-onset
depression.
These
are
particularly
sensitive
to
Hypothalamic-Pituitary-Adrenal
(HPA)
axis
signaling.
The
HPA
is
hyperactive
adolescent
depression,
and
interventions
that
attenuate
such
hyperactivity
hold
promise
as
potential
treatments.
Microbiome-Gut-Brain
(MGB)
an
important
pathway
through
which
stress
dysregulates
HPA-axis
activity
thus
exerts
deleterious
effects
on
brain.
Probiotic
agents,
alter
gut
microbiota
composition
by
introducing
bacterial
strains
with
beneficial
physiological
effects,
normalize
aberrant
reduce
depressive
symptoms
both
animal
studies
adult
clinical
trials.
While
utility
agents
treating
or
preventing
depression
remains
largely
unexplored,
recent
data
suggest
existence
window
during
probiotics
be
especially
efficacious
reducing
compared
observed
populations.
In
this
review,
we
outline
evidence
probiotic
use
development,
providing
novel
means
improving
among
Microbiome Research Reports,
Journal Year:
2025,
Volume and Issue:
4(2)
Published: April 17, 2025
The
initial
gut
colonization
of
the
infant
plays
a
pivotal
role
in
shaping
immune
system,
developing
intestinal
tract,
and
influencing
host
metabolism,
all
which
are
strongly
influenced
by
several
determinants,
such
as
gestational
age
at
birth,
mode
delivery,
neonatal
feeding
practices,
early-life
stress
(ELS),
exposure
to
perinatal
antibiotics.
However,
resulting
microbiome
(GM)
dysbiosis
may
alter
this
developmental
programming,
leading
long-term
adverse
health
outcomes.
This
narrative
review
synthesizes
current
knowledge
on
GM
development
its
impact
health.
Specifically,
it
addresses
how
affect
trajectory
physiological
processes,
predisposing
individuals
conditions
allergic
diseases,
metabolic
disorders,
type
1
diabetes,
inflammatory
bowel
atherosclerotic
cardiovascular
diseases.
In
addition,
examines
influence
probiotic
prebiotic
supplementation
during
pregnancy
early
life
composition,
well
ELS-induced
mental
Recent
research
suggests
that
microbiota
initiates
long-lasting
effects,
inadequate
or
insufficient
microbial
triggers
responses
associated
with
conditions.
Although
studies
have
reported
connection
between
ELS
both
prenatal
postnatal
periods,
unified
signature
linked
either
remains
be
fully
elucidated.
Thus,
future
needed
establish
causality
determine
whether
modifiable
factors
affecting
could
targeted
improve
health,
especially
children
exposed
contextual
Journal of Toxicology and Environmental Health Part B,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: April 29, 2025
From
a
biological
point
of
view,
Diversity,
Equity,
and
Inclusion
(DEI)
are
important
at
multiple
levels,
which
include
our
genetics,
microbiomes,
diets,
all
organ
system
interactions.
Considering
only
DEI's
sociological
aspects
is
equivalent
to
the
error
"throwing
out
baby
with
bath
water."
Variances
in
microbial
diversity
within
microbiomes
might
affect
health
through
systemic
interactions
affecting
metabolites,
maintaining
immune
homeostasis,
wound
healing
cellular
damage
from
an
infection,
physical
stress,
or
psychological
trauma.
An
imbalance
cell
subsets,
both
innate
adaptive,
microbes
any
lead
more
excessive
inflammation
oxidative
stress
less
regulation.
The
dysregulation
may
occur
due
loss
endometrial
barriers
enabling
spread
microbes,
environmental
pollutants,
allergens.
Heat
waves,
sleep
deprivation,
increased
prevalence
pollutants
such
as
polychlorinated
biphenyls,
weaken
endothelial
barriers,
be
responsible
for
enhanced
stresses.
Leakage
useful
gut
microbiota
into
periphery
initiate
inflammatory
responses,
altered
microbiome
gut-brain
axis
that
influences
mental
health.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: May 31, 2024
Abstract
Stress
in
early
life
can
affect
the
progeny
and
increase
risk
to
develop
psychiatric
cardiometabolic
diseases
across
generations.
The
cross-generational
effects
of
stress
have
been
modeled
mice
demonstrated
be
associated
with
epigenetic
factors
germline.
While
is
known
gut
microbial
features,
whether
its
persist
passed
not
well
defined.
Here
we
show
that
postnatal
shifts
fecal
composition
(binary
Jaccard
index)
throughout
life,
including
abundance
eight
amplicon
sequencing
variants
(ASVs).
Further
on
composition,
structure
(weighted
index),
16
ASVs
are
detected
two
These
accompanied
by
changes
bacterial
metabolites
any
generation.
results
suggest
community
induced
traumatic
perpetuated
from
exposed
parent
offspring.
