Hydroxyapatite
(HA)
is
widely
used
in
scaffolds
due
to
its
high
similarity
the
composition
natural
bone.
However,
weak
and
fragile
characteristics
of
synthetic
HA
limit
application.
The
strength
can
be
increased
by
incorporation
alumina
(Al2O3)
obtain
composites
with
extraordinary
compressive
biocompatibility.
HA-Al2O3
different
ratios
were
prepared
Vat
photopolymerization
3D
printing,
their
shrinkage,
porosity,
phase
biocompatibility
systematically
investigated.
In
addition,
Diamond
structure
scaffold
was
chosen
achieve
trade-off
relationship
between
porosity.
results
suggest
that
composite
20
vol%
possesses
maximum
60
has
optimal
A
compositional
gradient
from
proposed
satisfy
needs
parts
for
strength.
achieves
a
preferable
13.7
MPa
while
possessing
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Jan. 8, 2024
Abstract
Foreign
body
reaction
(FBR)
is
a
prevalent
yet
often
overlooked
pathological
phenomenon,
particularly
within
the
field
of
biomedical
implantation.
The
presence
FBR
poses
heavy
burden
on
both
medical
and
socioeconomic
systems.
This
review
seeks
to
elucidate
protein
“fingerprint”
implant
materials,
which
generated
by
physiochemical
properties
materials
themselves.
In
this
review,
activity
macrophages,
formation
foreign
giant
cells
(FBGCs),
development
fibrosis
capsules
in
context
are
introduced.
Additionally,
relationship
between
various
elucidated
detail,
as
an
overview
existing
approaches
technologies
employed
alleviate
FBR.
Finally,
significance
components
(metallic
non‐metallic
materials),
surface
CHEMISTRY
(charge
wettability),
physical
characteristics
(topography,
roughness,
stiffness)
establishing
also
well
documented.
conclusion,
aims
emphasize
importance
provides
current
perspectives
developing
with
anti‐FBR
properties.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 21, 2025
Neural
interface
technologies
are
increasingly
evolving
towards
bio-inspired
approaches
to
enhance
integration
and
long-term
functionality.
Recent
strategies
merge
soft
materials
with
tissue
engineering
realize
biologically-active
and/or
cell-containing
living
layers
at
the
tissue-device
that
enable
seamless
biointegration
novel
cell-mediated
therapeutic
opportunities.
This
review
maps
field
of
electronics
discusses
key
recent
developments
in
tissue-like
regenerative
bioelectronics,
from
biomaterials
surface-functionalized
bioactive
coatings
'biohybrid'
'all-living'
interfaces.
We
define
contextualize
terminology
this
emerging
highlight
how
biological
components
can
bridge
gap
clinical
translation.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 24, 2023
The
oral
cavity
comprises
an
environment
full
of
microorganisms.
Dysregulation
this
microbial-cellular
microenvironment
will
lead
to
a
series
diseases,
such
as
implant-associated
infection
caused
by
Staphylococcus
aureus
(S.
aureus)
biofilms
and
periodontitis
initiated
Streptococcus
oralis
oralis).
In
study,
liposome-encapsulated
indocyanine
green
(ICG)
rapamycin
drug-delivery
nanoparticle
(ICG-rapamycin)
is
designed
treat
prevent
two
typical
biofilm-induced
diseases
regulating
the
microenvironment.
ICG-rapamycin
elevates
reactive
oxygen
species
(ROS)
temperature
levels
facilitate
photodynamic
photothermal
mechanisms
under
near-infrared
(NIR)
laser
irradiation
for
anti-bacteria.
addition,
it
prevents
biofilm
formation
promoting
bacterial
motility
with
increasing
ATP
levels.
nanoparticles
modulate
interaction
reduce
cellular
inflammation
enhance
clearance,
which
includes
M2
polarization
macrophages,
upregulating
anti-inflammatory
factor
TGF-β,
enhancing
phagocytosis
macrophages.
Based
on
these
findings,
applied
implant-infected
animal
models
confirm
effects
in
vivo.
This
study
demonstrates
that
can
microenvironment,
thus
providing
promising
strategy
future
clinical
applications.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(32), P. 21221 - 21235
Published: July 30, 2024
The
mechanical
properties
of
nanoparticles
play
a
crucial
role
in
regulating
nanobiointeractions,
influencing
processes
such
as
blood
circulation,
tumor
accumulation/penetration,
and
internalization
into
cancer
cells.
Consequently,
they
have
significant
impact
on
drug
delivery
therapeutic
efficacy.
However,
it
remains
unclear
whether
how
macrophages
alter
their
biological
function
response
to
nanoparticle
elasticity.
Here,
we
report
the
nano-mechanical
effects
resulting
from
interactions
between
elastic
silica
(SNs)
macrophages.
SNs
with
variational
elasticity
Young's
moduli
ranging
81
837
MPa
were
synthesized,
was
demonstrated
that
M2
[tumor-associated
(TAMs)]
could
be
repolarized
M1
by
soft
SNs.
Additionally,
our
findings
revealed
cell
endocytosis,
membrane
tension,
curvature
protein
Baiap2,
cytoskeleton
all
influenced
Moreover,
mechanically
sensitive
Piezo1
activated,
leading
calcium
ion
influx,
activation
NF-κB
pathway,
initiation
an
inflammatory
response.
In
vivo
experiments
softest
enhanced
penetration
accumulation
TAMs
intratumoral
hypoxic
regions,
ultimately
inhibition
growth.
Taken
together,
this
study
has
established
cellular
feedback
mechanism
elasticity,
which
induces
plasma
deformation
subsequent
mechanosensitive
signals.
This
provides
distinctive
"nano-mechanical
immunoengineering"
strategy
for
reprogramming
enhance
immunotherapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(34), P. 23217 - 23231
Published: Aug. 14, 2024
Flexible
fiber-based
microelectrodes
allow
safe
and
chronic
investigation
modulation
of
electrically
active
cells
tissues.
Compared
to
planar
electrodes,
they
enhance
targeting
precision
while
minimizing
side
effects
from
the
device-tissue
mechanical
mismatch.
However,
current
manufacturing
methods
face
scalability,
reproducibility,
handling
challenges,
hindering
large-scale
deployment.
Furthermore,
only
a
few
designs
can
record
electrical
biochemical
signals
necessary
for
understanding
interacting
with
complex
biological
systems.
In
this
study,
we
present
method
that
utilizes
conductivity
easy
processability
MXenes,
diverse
family
two-dimensional
nanomaterials,
apply
thin
layer
MXene
coating
continuously
commercial
nylon
filaments
(30-300
μm
in
diameter)
at
rapid
speed
(up
15
mm/s),
achieving
linear
resistance
below
10
Ω/cm.
The
MXene-coated
are
then
batch-processed
into
free-standing
fiber
excellent
flexibility,
durability,
consistent
performance
even
when
knotted.
We
demonstrate
electrochemical
properties
these
electrodes
their
hydrogen
peroxide
(H
Matrix Biology Plus,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100172 - 100172
Published: March 1, 2025
Biomaterial
implants
are
a
critical
aspect
of
our
medical
therapies
and
biomedical
research
come
in
various
forms:
stents,
implantable
glucose
sensors,
orthopedic
implants,
silicone
drug
delivery
systems,
tissue
engineered
scaffolds.
Their
implantation
triggers
series
biological
responses
that
often
times
lead
to
the
foreign
body
response
subsequent
fibrotic
encapsulation,
dense
ECM-rich
capsule
isolates
biomaterial
renders
it
ineffective.
These
failure
biomaterials
is
major
hurdle
overcome
promoting
their
success.
Much
attention
has
been
given
macrophage
populations
for
inflammatory
component
these
but
recent
work
identified
an
important
role
T
cells
ability
modulate
fibroblast
activity
vice
versa.
In
this
review,
we
focus
on
cell-fibroblast
crosstalk
by
exploring
cell
subsets,
signaling
pathways,
have
shown
dictate
biomaterial-mediated
fibrosis.
We
then
highlight
emerging
technologies
model
systems
enable
new
insights
avenues
will
improve
outcomes.
