COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathways DOI Creative Commons
Ruisheng Ke, Yun Dai, Yixi Tu

et al.

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract Hepatocellular carcinoma (HCC) is a cancer with poor prognosis, underscoring the urgent need for enhanced detection and management. This study aimed to investigate role of Collectin Subfamily Member 10 (COLEC10) in HCC, which was revealed be associated various diseases. Bioinformatics tools, including GEO, cBioPortal, TCGA, were used identify differentially expressed genes. The prognostic significance COLEC10 assessed two patient cohorts, its functional impact on Hep3B SMMC7721 cells evaluated through CCK-8 Transwell assays. underlying mechanisms HCC progression explored using flow cytometry western blot. downregulated poorer overall survival disease progression. potential interaction COLEC10, CCBE1, FCN3 predicted. identified as indicators HCC. Overexpression inhibited proliferation, migration, invasion cells. overexpression induced G0/G1 cell cycle arrest suppressed epithelial–mesenchymal transition (EMT), regulated protein expression Hedgehog pathway phosphorylation key proteins PI3K-AKT pathway. an independent factor regulates EMT, Hedgehog, pathways, providing new ideas targeted therapy

Language: Английский

Embracing cancer complexity: Hallmarks of systemic disease DOI Open Access
Charles Swanton, Elsa Bernard,

Chris Abbosh

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(7), P. 1589 - 1616

Published: March 1, 2024

Language: Английский

Citations

161
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer DOI Creative Commons

Shi-Yang Li,

Jan A. Hammarlund,

Gang Wu

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(7)

Published: Feb. 6, 2024

Studies in shift workers and model organisms link circadian disruption to breast cancer. However, molecular rhythms noncancerous cancerous human tissues their clinical relevance are largely unknown. We reconstructed informatically, integrating locally collected, time-stamped biopsies with public datasets. For tissue, inflammatory, epithelial–mesenchymal transition (EMT), estrogen responsiveness pathways show modulation. Among tumors, clock correlation analysis demonstrates subtype-specific changes organization. Luminal A organoids informatic ordering of luminal samples exhibit continued, albeit dampened reprogrammed rhythms. CYCLOPS magnitude, a measure global rhythm strength, varied widely among samples. Cycling EMT pathway genes was markedly increased high-magnitude tumors. Surprisingly, patients tumors had reduced 5-y survival. Correspondingly, 3D cultures invasion following disruption. This study links cancer EMT, metastatic potential, prognosis.

Language: Английский

Citations

21
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis DOI
Yu Wang, Rajesh Narasimamurthy, Meng Qu

et al.

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(4), P. 546 - 556

Published: April 23, 2024

Language: Английский

Citations

19
The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

2
Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology DOI
Nityanand Bolshette, Hussam Ibrahim, Hans Reinke

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(11), P. 695 - 707

Published: June 8, 2023

Language: Английский

Citations

29
Circadian Control of Hepatic Ischemia/Reperfusion Injury via HSD17B13-Mediated Autophagy in Hepatocytes DOI
Hui Wang,

Meina Guo,

Baoyin Ren

et al.

Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care DOI Creative Commons

Xiaoyan Zhu,

Geraldine Maier, Satchidananda Panda

et al.

Trends in cancer, Journal Year: 2023, Volume and Issue: 10(3), P. 196 - 207

Published: Nov. 23, 2023

Circadian timekeeping mechanisms and cell cycle regulation share thematic biological principles in responding to signals, repairing cellular damage, coordinating metabolism, allocating resources for optimal function. Recent studies show interactions between regulators circadian clock components, offering insights into potential cancer treatment approaches. Understanding control of metabolism informs timing therapies reduce adverse effects enhance efficacy. adaptability lifestyle factors, such as activity, sleep, nutrition sheds light on their impact cancer. Leveraging regulatory prevention care is vital, most risk stems from modifiable lifestyles. Monitoring factors aids assessment targeted interventions across the continuum.

Language: Английский

Citations

21
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI‐1‐TGF‐β‐myoCAF‐Dependent Mechanism DOI Creative Commons
Jieyu Wu, Jing Xu, Qiqiao Du

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Abstract The circadian clock in animals and humans plays crucial roles multiple physiological processes. Disruption of homeostasis causes detrimental effects. Here, it is demonstrated that the disruption rhythm by genetic deletion mouse brain muscle ARNT‐like 1 (Bmal1) gene, coding for key transcription factor, augments an exacerbated fibrotic phenotype various tumors. Accretion cancer‐associated fibroblasts (CAFs), especially alpha smooth actin positive myoCAFs, accelerates tumor growth rates metastatic potentials. Mechanistically, Bmal1 abrogates expression its transcriptionally targeted plasminogen activator inhibitor‐1 (PAI‐1). Consequently, decreased levels PAI‐1 microenvironment instigate plasmin activation through upregulation tissue urokinase activator. activated converts latent TGF‐ β into form, which potently induces fibrosis transition CAFs latter promoting cancer metastasis. Pharmacological inhibition signaling largely ablates potentials colorectal cancer, pancreatic ductal adenocarcinoma, hepatocellular carcinoma. Together, these data provide novel mechanistic insights It reasonably speculated normalization patients provides a paradigm therapy.

Language: Английский

Citations

19
Stroke in the Time of Circadian Medicine DOI Open Access
Philipp Mergenthaler, Joyce S. Balami, Ain Neuhaus

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 770 - 790

Published: March 14, 2024

Time-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also important determinants clinical outcome. In this review, we provide a comprehensive overview interplay between chronobiology cerebrovascular disease. We discuss regulation pathophysiological mechanisms underlying onset or tolerance as well in vascular dementia. This includes cell death mechanisms, metabolism, mitochondrial function, inflammation/immunity. Furthermore, present evidence supporting link disrupted rhythms increased susceptibility to propose that biochemical physiological pathways brain increase damage after sleep attenuate treatment effectiveness during active phase. review underscores importance considering biology understanding pathology choice dementia speculates patient's chronotype may be an factor developing precision following

Language: Английский

Citations

7
Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk DOI Creative Commons
Gang Wang,

Xiaodi Jiang,

Pedram Torabian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216744 - 216744

Published: March 1, 2024

Hepatocellular carcinoma (HCC) stands as a formidable global health challenge due to its prevalence, marked by high mortality and morbidity rates. This cancer type exhibits multifaceted etiology, prominently linked viral infections, non-alcoholic fatty liver disease, genomic mutations. The inherent heterogeneity of HCC, coupled with proclivity for developing drug resistance, presents obstacles effective therapeutic interventions. Autophagy, fundamental catabolic process, plays pivotal role in maintaining cellular homeostasis, responding stressors such nutrient deprivation. In the context tumor cells exploit autophagy, either augmenting or impeding activity, thereby influencing tumorigenesis. comprehensive review underscores dualistic autophagy acting both pro-survival pro-death mechanism, impacting trajectory anti-carcinogenic potential is evident ability enhance apoptosis ferroptosis HCC cells. Pertinently, dysregulated fosters resistance carcinogenic context. Both epigenetic factors can regulate progression. Recognizing paramount importance progression, this introduces pharmacological compounds capable modulating autophagy—either inducing inhibiting it, promising avenues therapy.

Language: Английский

Citations

6