Boosting Electrocatalytic Ammonia Synthesis from Nitrate with a Dual Active Site Three-Dimensional Copper Electrode DOI
Jiangzhou Qin, Jihan Zhang, Yanyu Lü

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(41), P. 14969 - 14975

Published: Sept. 29, 2023

Unbridled anthropogenic activities severely disrupt natural nitrogen cycles, leading to significant environmental and energy-related issues, including the eutrophication of water high levels energy consumption in industrial fixation. A feasible promising approach toward attaining sustainable zero-carbon cycles is utilization clean electrical convert nitrate pollutants bodies into high-value products. In this study, metal (Ru/Co/Ni)-doped Cu electrodes were synthesized for electrocatalytic synthesis NH4+ at room temperature. The Ru–Cu CF electrode demonstrated exceptional performance, achieving a removal rate 99.9% (2000 mg·L–1 NO3––N) NH4+–N selectivity 91.2%. Furthermore, feasibility practical application was verified using electroplating wastewater, where it found that not only effectively converted NO3– NH4NO3, but also successfully recovered Cu2+ from wastewater. This discovery has potential optimize laborious environmentally damaging synthetic processes efficient green alternatives, thereby providing important theoretical guidance value development ammonia processes.

Language: Английский

Mechanical signatures in cancer metastasis DOI Creative Commons
Ayushi Agrawal,

Yousef Javanmardi,

Sara A. Watson

et al.

npj Biological Physics and Mechanics., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 4, 2025

Abstract The cancer metastatic cascade includes a series of mechanical barrier-crossing events, involving the physical movement cells from their primary location to distant organ. This review describes changes that influence tumour proliferation, progression, and metastasis. We identify potential signatures at every step discuss some latest mechanobiology-based therapeutic interventions highlight importance interdisciplinary approaches in diagnosis treatment.

Language: Английский

Citations

4
Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment DOI Creative Commons
Maria Kalli, Triantafyllos Stylianopoulos

APL Bioengineering, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 21, 2024

Within the complex tumor microenvironment, cells experience mechanical cues-such as extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, shear stress-that significantly impact cancer cell behavior immune responses. Recognizing significance these cues not only sheds light on progression but also holds promise for identifying potential biomarkers that would predict therapeutic outcomes. However, standardizing methods studying how affect is challenging. This challenge stems from limitations traditional

Language: Английский

Citations

10
Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy DOI Creative Commons
Fotios Mpekris, Myrofora Panagi, Antonia Charalambous

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(7), P. 101626 - 101626

Published: June 28, 2024

Solid tumor pathology, characterized by abnormalities in the microenvironment (TME), challenges therapeutic effectiveness. Mechanical factors, including increased stiffness and accumulation of intratumoral forces, can determine success cancer treatments, defining tumor's "mechanopathology" profile. These cause extensive vascular compression, leading to hypoperfusion hypoxia. Hypoperfusion hinders drug delivery, while hypoxia creates an unfavorable TME, promoting progression through immunosuppression, heightened metastatic potential, resistance, chaotic angiogenesis. Strategies targeting TME mechanopathology, such as stroma normalization, hold promise enhancing therapies with some already advancing clinic. Normalization be achieved using anti-angiogenic agents, mechanotherapeutics, immune checkpoint inhibitors, engineered bacterial therapeutics, metronomic nanomedicine, ultrasound sonopermeation. Here, we review methods developed rectify which have even led cures preclinical models, discuss their bench-to-bedside translation, derivation biomarkers from mechanopathology for personalized therapy.

Language: Английский

Citations

10
A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells DOI Creative Commons
Vatsal Kumar, S. M. Naqvi, Anneke S.K. Verbruggen

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114043 - 114043

Published: April 18, 2024

Bone is highly susceptible to cancer metastasis, and both tumor bone cells enable invasion through a "vicious cycle" of biochemical signaling. Tumor metastasis into also alters biophysical cues cells, which are sensitive their mechanical environment. However, the mechanobiological feedback between these that perpetuate this cycle has not been studied. Here, we develop advanced in vitro computational models provide an understanding how growth regulated by synergistic influence tumor-bone cell signaling cues. In particular, multicellular healthy metastatic model can account for physiological signals within custom bioreactor. These successfully recapitulated mineralization, responses, osteolysis, activity. Ultimately, demonstrate stimulus provided protective effects against tumor-induced confirming importance factors development.

Language: Английский

Citations

4
Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling DOI Creative Commons
Y. Liu, Jianxujie Zheng, Lingyan Zhong

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Hypertension, the leading cause of cardiovascular disease and premature mortality, is characterized by increased vessel stretch alterations in vascular smooth muscle cells (VSMCs). In this study, a vessel-on-a-chip model developed to simulate both physiological pathological conditions alongside mouse hypertension. Proteomics analysis applied investigate changes VSMCs using system compared these findings with data from model. The results demonstrates that enhances expression contractile markers VSMCs. Additionally, chip effectively replicates cellular responses stress, including upregulation ERK signaling, calcium ion transport pathway, integrin signaling endoplasmic reticulum toll-like receptor activation, oxidative synthesis sphingolipids ceramides. These indicate successfully mimics vivo biological events associated holds promise for advancing study vessel-related diseases facilitating development novel hypertension therapeutics.

Language: Английский

Citations

0
Softness or Stiffness What Contributes to Cancer and Cancer Metastasis? DOI Creative Commons
Claudia Tanja Mierke

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 584 - 584

Published: April 12, 2025

Beyond the genomic and proteomic analysis of bulk single cancer cells, a new focus research is emerging that based on mechanical cells. Therefore, several biophysical techniques have been developed adapted. The characterization like human cell lines, started with their at mostly timepoint. A universal hypothesis has proposed cells need to be softer migrate invade tissues subsequently metastasize in targeted organs. Thus, softness suggested serve as physical marker for malignancy types. However, it turned out there exists opposite phenomenon, namely stiffer are more migratory invasive therefore lead metastases. These contradictory results question universality role malignant progression cancers. Another problem various used can affect properties making even difficult compare different studies. Apart from instrumentation, culture measurement conditions influence measurements. review highlights main advances discusses strength weaknesses approaches, questions whether passive still state-of-the art. Besides models, setups, microenvironment characteristics presented debated. Finally, combinatorial approaches determine potential tumors, such involvement ECM, homogeneous or heterogeneous association, biological multi-omics analyses, together dynamic-mechanical highlighted frontiers research.

Language: Английский

Citations

0
Volumetric compression for engineering living systems DOI
Yiwei Li, Ming Guo

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Language: Английский

Citations

2
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition DOI Creative Commons
Maria Kalli, Fotios Mpekris, Antonia Charalambous

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 27, 2024

Pancreatic cancer remains one of the most lethal malignancies, with limited treatment options and poor prognosis. A common characteristic among pancreatic patients is biomechanically altered tumor microenvironment (TME), which others responsible for elevated mechanical stresses in interior. Although significant research has elucidated effect stress on cell proliferation migration, it not yet been investigated how could affect drug sensitivity. Here, we demonstrated that triggers autophagy activation, correlated increased resistance to oxaliplatin cells. Our results demonstrate inhibition using hydroxychloroquine (HCQ) enhanced oxaliplatin-induced apoptotic death cells exposed stress. The combined HCQ losartan, a known modulator abnormalities tumors, synergistically therapeutic efficacy murine models. Furthermore, our study revealed use losartan alleviate levels restore blood vessel integrity beyond its role modulation. These findings underscore potential co-targeting as promising strategy overcome increase chemotherapy efficacy. Inhibiting mechanically induced improves especially when losartan. This combination, only increases oxaliplatin's potency but also integrity.

Language: Английский

Citations

2
Boosting Electrocatalytic Ammonia Synthesis from Nitrate with a Dual Active Site Three-Dimensional Copper Electrode DOI
Jiangzhou Qin, Jihan Zhang, Yanyu Lü

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(41), P. 14969 - 14975

Published: Sept. 29, 2023

Unbridled anthropogenic activities severely disrupt natural nitrogen cycles, leading to significant environmental and energy-related issues, including the eutrophication of water high levels energy consumption in industrial fixation. A feasible promising approach toward attaining sustainable zero-carbon cycles is utilization clean electrical convert nitrate pollutants bodies into high-value products. In this study, metal (Ru/Co/Ni)-doped Cu electrodes were synthesized for electrocatalytic synthesis NH4+ at room temperature. The Ru–Cu CF electrode demonstrated exceptional performance, achieving a removal rate 99.9% (2000 mg·L–1 NO3––N) NH4+–N selectivity 91.2%. Furthermore, feasibility practical application was verified using electroplating wastewater, where it found that not only effectively converted NO3– NH4NO3, but also successfully recovered Cu2+ from wastewater. This discovery has potential optimize laborious environmentally damaging synthetic processes efficient green alternatives, thereby providing important theoretical guidance value development ammonia processes.

Language: Английский

Citations

4